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Negative symptoms in schizophrenia: considerations for clinical trials

Publikováno v: Psychopharmacology. 115:221-228

There is little agreement about the methodology of clinical trials of antipsychotic drugs in patients with negative symptoms. A literature review revealed wide variation in experimental design, rating scales and study duration. This reflects differin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291cc55a5f6284492219370d2332becb
https://doi.org/10.1007/bf02244775

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Pilot Controlled Double-Blind Study of the Hypnotic Effects of Zolpidem in Patients with Chronic ‘Learned’ Insomnia: Psychometric and Polysomnographic Evaluation

Autor: Attali P, F X Eich, W M Herrmann, S T Kubicki, S Boden, J P Coquelin

Publikováno v: Journal of International Medical Research. 21:306-322

In a pilot double-blind trial in 21 patients with learned or idiopathic insomnia (DSM-IIIR), patients received placebo for 1 week (nights 1 – 7), either active (Zolpidem, 10 mg) or placebo treatment for 2 weeks (nights 8 – 21) and then placebo fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ec3edbdd46fcf7f295c8508d945595
https://doi.org/10.1177/030006059302100602

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Long-Term Polysomnographic Study of the Efficacy and Safety of Zolpidem in Elderly Psychiatric In-Patients with Insomnia

Autor: J P Coquelin, Linden J, F X Eich, Guendel L, Attali P, Kyrein Hj, Kummer J

Publikováno v: Journal of International Medical Research. 21:171-184

The effects of 20 mg Zolpidem were studied in an open, polysomnographically-monitored 179 day trial in 14 elderly psychiatric patients suffering from severe insomnia. After a placebo run-in of 7 days, Zolpidem was given for 179 days followed by a 30-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bab666c4db0d9d75f3bb137f21d0a9e
https://doi.org/10.1177/030006059302100402

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Amisulpride doses and plasma levels in different age groups of patients with schizophrenia or schizoaffective disorder

Autor: C Hiemke, J Sachse, Matthias J. Müller, F. X. Eich, B. Regenbogen, Sebastian Härtter

Publikováno v: Journal of psychopharmacology (Oxford, England). 23(3)

Abstract Because of a unique pharmacodynamic profile, amisulpride seems appropriate for treatment of elderly patients with schizophrenia. In a large-scale naturalistic therapeutic drug monitoring study, daily amisulpride dose, trough and dose-correct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331cf864c8fb54042ae9bcd296f46d8a
https://pubmed.ncbi.nlm.nih.gov/18562411

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Remission of severely impaired subjective wellbeing in 727 patients with schizophrenia treated with amisulpride

Autor: Michael Linden, Martin Lambert, Dieter Naber, F. X. Eich, Benno G. Schimmelmann, M. Schacht

Objective: Studies of subjective wellbeing (SW) in schizophrenia have missed to define and to assess rate and predictors of SW response (SW-res) and SW remission (SW-rem). Method: A total of 727 patients with schizophrenia and severely impaired SW at

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https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=33846274595

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Gender aspects in the clinical treatment of schizophrenic inpatients with amisulpride: a therapeutic drug monitoring study

Autor: C Hiemke, Sebastian Härtter, J Sachse, B. Regenbogen, Matthias J. Müller, F. X. Eich

Publikováno v: Pharmacopsychiatry. 39(2)

INTRODUCTION: It is assumed that female and male schizophrenic patients respond differentially to acute and chronic treatment with antipsychotics because of pharmacokinetic and pharmacodynamic factors linked to hormonal and constitutional gender diff

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https://pubmed.ncbi.nlm.nih.gov/16555163

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Competence to give informed consent to clinical studies. Statement by the taskforce on 'ethical and legal questions' of the Association for Neuropsychopharmacology and Pharmacopsychiatry ('Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie [AGNP]')

Autor: H.-J. Möller, J. Aldenhoff, Norbert Nedopil, F. X. Eich, W. Maier, Jürgen Fritze, Markus Gastpar, Amelung K

Publikováno v: Pharmacopsychiatry. 32(5)

Over the last 50 years, patient autonomy has become an increasingly important part of the principles of medical ethics, or rather of the ethics of the doctor-patient relationship. While the principle of charity and the associated paternalism became l

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https://pubmed.ncbi.nlm.nih.gov/10543377

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