Zobrazeno 1 - 10
of 16
pro vyhledávání: '"F. Wieland Goetzke"'
Publikováno v:
Angewandte Chemie. 135
Publikováno v:
Chemical Science
Chiral, substituted cyclobutanes are common motifs in bioactive compounds and intermediates in organic synthesis but few asymmetric routes for their synthesis are known. Herein we report the Rh-catalyzed asymmetric hydrometallation of a range of meso
Autor:
F. Wieland Goetzke, Cornelius Gropp, Anatol Schwab, Etienne J. Donckèle, Carlo Thilgen, François Diederich
Publikováno v:
Helvetica Chimica Acta. 105
Publikováno v:
Nature Chemistry. 13:880-886
Stereodefined four-membered rings are common motifs in bioactive molecules and versatile intermediates in organic synthesis. However, the synthesis of complex, chiral cyclobutanes is a largely unsolved problem and there is a need for general and modu
Tropane derivatives are extensively used in medicine, but catalytic asymmetric methods for their synthesis are underexplored. Here we report Rh-catalyzed asymmetric Suzuki-Miyaura type cross-coupling reactions between a racemic N-Bocnortropane-derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687a7365fe853bb7680c50d846d4b565
https://ora.ox.ac.uk/objects/uuid:60318ffc-0ac5-498e-89c5-d2c2f2bfb575
https://ora.ox.ac.uk/objects/uuid:60318ffc-0ac5-498e-89c5-d2c2f2bfb575
Publikováno v:
ACS catalysis. 12(15)
Tropane derivatives are extensively used in medicine, but catalytic asymmetric methods for their synthesis are underexplored. Here, we report Rh-catalyzed asymmetric Suzuki-Miyaura-type cross-coupling reactions between a racemic
Autor:
F. Wieland Goetzke, Tobias Hüfner-Wulsdorf, François Diederich, Christoph Hohn, Klaus Reuter, F.R. Ehrmann, Maurice Sebastiani, Adrian Härtsch, E. Hassaan, Gerhard Klebe, Levon D. Movsisyan
Publikováno v:
Journal of Medicinal Chemistry, 63 (13)
Fragment-based lead discovery was applied to tRNA-guanine transglycosylase, an enzyme modifying post-transcriptionally tRNAs in Shigella, the causative agent of shigellosis. TGT inhibition prevents translation of Shigella's virulence factor VirF, hen
Publikováno v:
Organic Letters. 22:2991-2994
We report the catalytic asymmetric synthesis of Tafluprost (1), a prostaglandin analogue. This synthesis demonstrates a new approach to prostaglandins involving symmetrization and desymmetrization of a racemic precursor to control the absolute and re
Publikováno v:
PATAI'S Chemistry of Functional Groups
In this Account, the authors describe their progress in developing catalytic asymmetric C(sp3)–C(sp3) and C(sp3)–C(sp2) cross-coupling reactions. Whereas most catalytic enantioselective transformations rely on prochiral or meso starting materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2056f8717ee0673770dec5dcd4eca7
https://doi.org/10.1055/s-0040-1706033
https://doi.org/10.1055/s-0040-1706033