Zobrazeno 1 - 10
of 263
pro vyhledávání: '"F. W. Jackson"'
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273797 (2022)
There is growing evidence to suggest that phosphohistidines are present at significant levels in mammalian cells and play a part in regulating cellular activity, in particular signaling pathways related to cancer. Because of the chemical instability
Externí odkaz:
https://doaj.org/article/573de6f031b249249d353038f7557999
Autor:
Philip A. P. Reeve, Urszula Grabowska, Lourdes Salvador Oden, Daniel Wiktelius, Fredrik Wångsell, Richard F. W. Jackson
Publikováno v:
ACS Omega, Vol 4, Iss 6, Pp 10854-10865 (2019)
Externí odkaz:
https://doaj.org/article/aba17e3c7c414378b660bf2669f91fc2
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 9, Pp 1336-1338 (2019)
The title compound, C7H4F3NO2, 3-trifluoromethyl-1H-pyrrolo[1,2-c]oxazol-1-one, is the first crystal structure of the pyrrolo[1,2-c]oxazole ring system: the fused ring system is almost planar (r.m.s. deviation = 0.006 Å). In the crystal, weak C—H.
Externí odkaz:
https://doaj.org/article/5c5d9e96cc284a08840dc1fa0b9aa5a9
Autor:
Urszula Grabowska, Richard F. W. Jackson, Lourdes Salvador Oden, Fredrik Wångsell, Philip A. P. Reeve, Daniel Wiktelius
Publikováno v:
ACS Omega, Vol 4, Iss 6, Pp 10854-10865 (2019)
ACS Omega
ACS Omega
A range of enantiomerically pure protected side-chain-fluorinated amino acids has been prepared (13 examples) by treatment of protected amino acids containing unsaturated side chains with a combination of Fe(III)/NaBH4 and Selectfluor. The modificati
Autor:
Mehul V. Makwana, Michael P. Williamson, Richard F. W. Jackson, Sandra van Meurs, Richmond Muimo, Andrea M. Hounslow
Protein phosphorylation plays a key role in many cellular processes but there is presently no accurate information or reliable procedure to determine the relative abundance of many phosphoamino acids in cells. At pH ≤ 8, phosphohistidine is unstabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6be4d6f2ea826a711af85a087a35274
https://doi.org/10.1101/2020.12.03.409540
https://doi.org/10.1101/2020.12.03.409540
Autor:
Mehul Makwana, Cleide Dos Santos Souza, Barry T. Pickup, Mark J. Thompson, Santosh Kumar Lomada, Yushi Feng, Thomas Wieland, Richard F. W. Jackson, Richmond MUIMO
Non-hydrolysable stable analogues of τ-pHis and π-pHis have been designed using electrostatic surface potential calculations, and subsequently synthesized. The τ-pHis and π-pHis analogues (phosphopyrazole 8 and pyridyl amino amide 13, respectivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fdc6226da1290a1dd6edfc80af08c8
https://doi.org/10.26434/chemrxiv.12993371.v1
https://doi.org/10.26434/chemrxiv.12993371.v1
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications
The title compound is the first crystal structure of the pyrrolo[1,2-c]oxazole ring system. In the crystal, weak C—H⋯O and C—H⋯F hydrogen bonds link the molecules into [001] chains and π–π stacking interactions consolidate the struc
Publikováno v:
The Journal of Organic Chemistry. 81:8386-8393
A range of 7-oxo, 8-oxo, and 9-oxo amino acids, analogues of 8-oxo-2-aminodecanoic acid, one of the key components of the cyclic tetrapeptide apicidin, have been prepared by a three-step process involving copper-catalyzed allylation of serine-, aspar
Publikováno v:
Chemical Communications. 51:7305-7308
We report the synthesis of a stable analogue of τ-phosphohistidine: 4-phosphopyrazol-2-yl alanine (pPza). Polyclonal antibodies generated against the mimic show high reactivity and selectivity for τ-phosphohistidine, with minor or no cross-reactivi
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 98(3)
Protein phosphorylation is an important post-translational modification that is an integral part of cellular function. The O-phosphorylated amino-acid residues, such as phosphoserine (pSer), phosphothreonine (pThr) and phosphotyrosine (pTyr), have do