Zobrazeno 1 - 10
of 13
pro vyhledávání: '"F. W. Bonner"'
Lack of Peroxisome Proliferation in Marmoset Liver Following Treatment with Ciprofibrate for 3 Years
Publikováno v:
Toxicological Sciences. 22:58-64
Lack of Peroxisome Proliferation in Marmoset Liver Following Treatment with Ciprofibrate for 3 Years. Graham, M. J., Wilson, S. A., Winham, M. A., Spencer, A. J., Rees, J. A., Old, S. L., and Bonner, F. W. (1994). Fundam. Appl. Toxicol. 22, 58-64. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e63183f26e84f7f92627f57f96118ca
https://doi.org/10.1093/toxsci/22.1.58
https://doi.org/10.1093/toxsci/22.1.58
Autor:
E S, Harpur, F W, Bonner
Publikováno v:
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement. 16
In summary, the benefits of a mechanistic toxicology approach include increased understanding of the processes underlying primary pathology, the development of predictive capability, enhanced decision making and improved responsiveness to regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3bcfc14544f81a6b48c2bcb02f40127
https://pubmed.ncbi.nlm.nih.gov/8192579
https://pubmed.ncbi.nlm.nih.gov/8192579
Publikováno v:
Molecular pharmacology. 42(5)
Nephrotoxic lesions were induced in Fischer 344 rats using HgCl2, a proximal tubular toxin, and 2-bromoethanamine (BEA), a medullary toxin. Biochemical effects of these toxins on urinary composition were observed by high resolution 1H NMR spectroscop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b0349d801088c347641a4670d206bb5b
https://pubmed.ncbi.nlm.nih.gov/1435756
https://pubmed.ncbi.nlm.nih.gov/1435756
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 20(11)
1. The effects of different dosing regimens of three hypolipidaemic, peroxisome-proliferator drugs on hepatic enzymes in the Fischer rat following 26 weeks treatment have been studied. 2. In study 1, with once-daily dosing (dose levels based on compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c584e0a0c2abc0f6cdc7417b6bcc1f
https://pubmed.ncbi.nlm.nih.gov/2275209
https://pubmed.ncbi.nlm.nih.gov/2275209
Autor:
F. W. Bonner
Publikováno v:
Journal of Applied Toxicology. 10:76-76
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74aaf2eccf87d2e6fdd0f9019ef94860
https://doi.org/10.1002/jat.2550100118
https://doi.org/10.1002/jat.2550100118
Publikováno v:
Journal of Applied Toxicology. 8:29-34
The effect of amrinone on platelet production was differentiated from that of a known bone-marrow cytotoxic agent (cyclophosphamide) and anti-platelet serum (APS). The rate of platelet production has been observed over a 4-day period in the Gunn rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54b549f3343a2ff424f21220d52013d
https://doi.org/10.1002/jat.2550080106
https://doi.org/10.1002/jat.2550080106
Publikováno v:
Journal of Applied Toxicology. 6:437-441
Platelet counts are routinely assessed from whole blood samples and recent technical advances enable the total platelet counts to be complemented by additional information which fully profiles the platelet population. In this report the platelet coun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82c02a190ab442fac946bf1e0f716b4
https://doi.org/10.1002/jat.2550060610
https://doi.org/10.1002/jat.2550060610
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 13(2)
The pharmacokinetic characteristics of amrinone have been studied in six female marmosets following oral administration of 1, 12.5, 25, 50 and 75 mg.kg-1 and an intravenous dose of 1mg.kg-1. The mean plasma AUC0 infinity was determined at each dose l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e19d2a215ee950ae57f5bc2fc1d955
https://pubmed.ncbi.nlm.nih.gov/3145204
https://pubmed.ncbi.nlm.nih.gov/3145204
Publikováno v:
Research communications in chemical pathology and pharmacology. 51(2)
Amrinone was found to inhibit platelet aggregation in human whole blood in a dose dependent manner, and at physiological levels of the drug. Statistically significant drug-related decreases in aggregation were observed with collagen, ADP and arachido
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1545eccbb21f62de9e771750f9e4242f
https://pubmed.ncbi.nlm.nih.gov/3083485
https://pubmed.ncbi.nlm.nih.gov/3083485
Publikováno v:
Nephrotoxicity ISBN: 9781475720426
Para-aminophenol (PAP) produces necrosis of proximal convoluted tubules acutely in the rat after a single injection (1), and has been demonstrated to be a minor metabolite of paracetamol in the Fischer 344 (F344) rat and Fischer-derived isolated perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3581029da4991c372052a88b4c2d73fa
https://doi.org/10.1007/978-1-4757-2040-2_66
https://doi.org/10.1007/978-1-4757-2040-2_66
