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pro vyhledávání: '"F. Virzi"'
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Autor:
Mary Rusckowski, Charles R. Cantor, Donald J. Hnatowich, M. Fogarasi, Cassandra L. Smith, P. Winnard, Takeshi Sano, F. Virzi
Publikováno v:
Bioconjugate Chemistry. 6:139-144
Consideration is now being given to the use of avidin (or streptavidin) and biotin for radiotherapy of tumor. Accordingly, the goal of this study was to radiolabel a mouse metallothionein-streptavidin fusion protein with 188Re and to compare its prop
Publikováno v:
Nuclear Medicine Communications. 16:38-46
This paper describes a method for measuring tracer kinetics in organs which are larger than the field of view of a gamma camera, by performing initial dynamic studies on part of that organ, followed by a later study to determine the tracer content of
Publikováno v:
Nuclear Medicine Communications. 16:47-54
Previously, this laboratory reported that in mice pre-targeted with unlabelled streptavidin, the biodistribution of 111 In administered of one biotin derivative (EB1) was superior to that of another derivative (DB2). In addition, a Scatchard analysis
Publikováno v:
Nuclear Medicine and Biology. 20:189-195
Because of its short physical half life, the use of anti-tumor antibodies radiolabeled with 99mTc has necessitated early (i.e. 2-6 h post-administration) imaging. It is possible that at these early times localization of antibodies in certain tumors m
Autor:
D J, Hnatowich, P, Winnard, F, Virzi, M, Fogarasi, T, Sano, C L, Smith, C R, Cantor, M, Rusckowski
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 36(12)
Single-stranded RNA and DNA oligonucleotides may be useful as radiopharmaceuticals for antisense and other in vivo applications if convenient methods for stably attaching radionuclides such as 99mTc can be developed.To radiolabel DNA with 99mTc, we h
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 35(1)
Recently, a method for the direct labeling of antibodies with 99mTc was described in which sulfhydryls were reportedly generated by reduction of antibody disulfides with ascorbic acid. Thereafter, these proteins may be labeled at high efficiency with
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 34(1)
To investigate the in vivo and in vitro properties of 99mTc when labeled to antibodies via one direct and one indirect method, the B72.3 and C110 IgG antibodies were radiolabeled directly via stannous ion reduction and indirectly via the hydrazino ni
Publikováno v:
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 19(2)
To simplify the synthesis of macrocyclic chelators, commercially available macrocyclic amines were condensed with halogenated acetic acid to prepare the five chelators 12N4 (DOTA), 14N4 (TETA), 15N4, 9N3 and 12N3. Only 12N4 and 9N3 showed efficient l