Zobrazeno 1 - 10
of 870
pro vyhledávání: '"F. Van Leuven"'
Autor:
I. Dewachter, L. Ris, T. Jaworski, C.M. Seymour, A. Kremer, P. Borghgraef, H. De Vijver, E. Godaux, F. Van Leuven
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 2, Pp 193-200 (2009)
Accumulating evidence implicates deregulation of GSK3ß as a converging pathological event in Alzheimer's disease and in neuropsychiatric disorders, including bipolar disorder and schizophrenia. Although these neurological disorders share cognitive d
Externí odkaz:
https://doaj.org/article/32ff4496717740bb91a94b5488e3814b
Autor:
R. Nuydens, G. Van Den Kieboom, C. Nolten, C. Verhulst, P. Van Osta, K. Spittaels, C. Van den Haute, E. De Feyter, H. Geerts, F. Van Leuven
Publikováno v:
Neurobiology of Disease, Vol 9, Iss 1, Pp 38-48 (2002)
Coexpression of constitutively active GSK-3β[S9A] rescued the axonal pathology induced by overexpression of human tau in transgenic mice (Spittaels et al., (2000) J. Biol. Chem. 275, 41340–41349). We isolated dorsal root ganglion (DRG) neuronal cu
Externí odkaz:
https://doaj.org/article/634bf00584894df29d80bbf4c038cd48
Autor:
C. Van den Haute, K. Spittaels, J. Van Dorpe, R. Lasrado, K. Vandezande, I. Laenen, H. Geerts, F. Van Leuven
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 1, Pp 32-44 (2001)
The potential contribution of cyclin-dependent protein kinase 5 (cdk5) to hyperphosphorylate protein tau, as claimed in Alzheimer's disease, was investigated in vivo. We generated single, double, and triple transgenic mice that coexpress human cdk5 a
Externí odkaz:
https://doaj.org/article/57c33427603946329a79138dbac401df
Akademický článek
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Autor:
Anneke Kremer, Saak V. Ovsepian, Mario M. Dorostkar, G Aramuni, F. Van Leuven, Severin Filser, Christian Schön, Simon M. Ochs, Julia Pöschl, Jochen Herms
Publikováno v:
Europe PubMed Central
Molecular psychiatry 20(4), 482-489 (2014). doi:10.1038/mp.2014.55
Molecular Psychiatry
Molecular psychiatry 20(4), 482-489 (2014). doi:10.1038/mp.2014.55
Molecular Psychiatry
Central nervous glycogen synthase kinase 3β (GSK3β) is implicated in a number of neuropsychiatric diseases, such as bipolar disorder, depression, schizophrenia, fragile X syndrome or anxiety disorder. Many drugs employed to treat these conditions i
Autor:
F. Van Leuven, Kim Serdons, Guy Bormans, Alfons Verbruggen, Peter Borghgraef, M. Van Eeckhoudt, Hank F. Kung, Dominique Vanderghinste, T. de Groot
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 52:473-481
Uncharged derivatives of thioflavin-T have known in vitro and in vivo affinity for amyloid β. We synthesized and evaluated two derivatives with a fluorine-18 labelled fluoropropoxy substituent either at the 6-position or at the 2′-position of the
Autor:
Emile Godaux, Laurence Ris, Anneke Kremer, Peter Borghgraef, F. Van Leuven, Claire M. Seymour, Ilse Dewachter, H De Vijver, Tomasz Jaworski
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 2, Pp 193-200 (2009)
Accumulating evidence implicates deregulation of GSK3ss as a converging pathological event in Alzheimer's disease and in neuropsychiatric disorders, including bipolar disorder and schizophrenia. Although these neurological disorders share cognitive d
Autor:
Herman Devijver, S. Croes, Robert K. Filipkowski, Christina Priller, D. Terwel, Peter Borghgraef, F. Van Leuven, Ilse Dewachter, Jochen Herms, Emile Godaux, J. Neyton, Laurence Ris, Maarten Gysemans, Leszek Kaczmarek
Publikováno v:
Neurobiology of Aging. 30:241-256
Evidence is accumulating for a role for amyloid peptides in impaired synaptic plasticity and cognition, while the underlying mechanisms remain unclear. We here analyzed the effects of amyloid peptides on NMDA-receptor function in vitro and in vivo. A
Autor:
T. Verduyckt, K. Van Laere, Kim Serdons, Guy Bormans, Peter Vermaelen, Jan Cleynhens, F. Van Leuven, Peter Borghgraef, Alfons Verbruggen, C Terwinghe, Dominique Vanderghinste, Hank F. Kung
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:602-605
2-(4'-[(18)F]fluorophenyl)-1,3-benzothiazole was synthesized as a fluorine-18 labelled derivative of the Pittsburg Compound-B (PIB), which has known affinity for amyloid beta and promising characteristics as tracer for in vivo visualisation of amyloi
Autor:
F. Van Leuven, Emile Godaux, Laurence Ris, Bernd Nilius, Peter Borghgraef, Ilse Dewachter, Thomas Voets, S. Croes, Herman Devijver
Publikováno v:
Neurobiology of Aging. 29:639-652
The function of presenilin1 (PS1) in intra-membrane proteolysis is undisputed, as is its role in neurodegeneration in FAD, in contrast to its exact function in normal conditions. In this study, we analyzed synaptic plasticity and its underlying mecha