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Akademický článek

Patient iPSC-derived neural progenitor cells display aberrant cell cycle control, p53, and DNA damage response protein expression in schizophrenia

Autor: Aaron Stahl, Johanna Heider, Richard Wüst, Andreas J. Fallgatter, Katja Schenke-Layland, Hansjürgen Volkmer, Markus F. Templin

Publikováno v: BMC Psychiatry, Vol 24, Iss 1, Pp 1-18 (2024)

Abstract Background Schizophrenia (SCZ) is a severe psychiatric disorder associated with alterations in early brain development. Details of underlying pathomechanisms remain unclear, despite genome and transcriptome studies providing evidence for abe

Externí odkaz: https://doaj.org/article/51489a1947494cdb8ff5ce2b001fdb76

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Akademický článek

Antibody Response against SARS-CoV-2 and Seasonal Coronaviruses in Nonhospitalized COVID-19 Patients

Autor: Natalia Ruetalo, Ramona Businger, Karina Althaus, Simon Fink, Felix Ruoff, Michaela Pogoda, Angelika Iftner, Tina Ganzenmüller, Klaus Hamprecht, Bertram Flehmig, Tamam Bakchoul, Markus F. Templin, Michael Schindler

Publikováno v: mSphere, Vol 6, Iss 1 (2021)

There is strong interest in the nature of the neutralizing antibody response against SARS-CoV-2 in infected individuals. For vaccine development, it is especially important which antibodies confer protection against SARS-CoV-2, if there is a phenomen

Externí odkaz: https://doaj.org/article/04a7c3e4823c4a918fd867a934553a0b

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Akademický článek

A bead-based western for high-throughput cellular signal transduction analyses

Autor: Fridolin Treindl, Benjamin Ruprecht, Yvonne Beiter, Silke Schultz, Anette Döttinger, Annette Staebler, Thomas O. Joos, Simon Kling, Oliver Poetz, Tanja Fehm, Hans Neubauer, Bernhard Kuster, Markus F. Templin

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

Dissecting cellular signalling requires the analysis of large numbers of proteins. Here the authors describe DigiWest, a high-throughput protein detection method that combines the concept of western and widely-used bead array systems that allows rapi

Externí odkaz: https://doaj.org/article/cd4dedf92230459d95726b4e2994b33f

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Altered Proinflammatory Responses to Polyelectrolyte Multilayer Coatings Are Associated with Differences in Protein Adsorption and Wettability

Autor: Anne Zeck, Nicole Schneiderhan-Marra, Sandra Maier, Markus F. Templin, Meike Jakobi, Christopher Shipp, Claus Burkhardt, Luisa Pickarski, Nora Feuerer, Elsa Arefaine, Florian Billing, Simon Fink, Robin Kretz, Rumen Krastev, Hanna Hartmann, Bernadette Walter

Publikováno v: ACS Applied Materials & Interfaces. 13:55534-55549

A full understanding of the relationship between surface properties, protein adsorption, and immune responses is lacking but is of great interest for the design of biomaterials with desired biological profiles. In this study, polyelectrolyte multilay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4360a19e6fb6e18892ef9fd1c044de
https://doi.org/10.1021/acsami.1c16175

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Tris(hydroxymethyl)aminomethane Compatibility with N-Hydroxysuccinimide Ester Chemistry: Biotinylation of Peptides and Proteins in TRIS Buffer

Autor: Ulrich Rothbauer, Anne Zeck, Cornelia Sommersdorf, Markus F. Templin, Oliver Poetz, Sandra Maier, Thomas O. Joos, Ulrich Kratzer, Teresa R Wagner

Publikováno v: Bioconjugate Chemistry. 32:1960-1965

N-Hydroxysuccinimide esters of small molecules are widely used to modify biomolecules such as antibodies or proteins. Primary amine groups preferably react with the ester to form covalent amide bonds. Currently, protocols strongly recommend replacing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed19b023af77ddaa80486dfacefdeb8c
https://doi.org/10.1021/acs.bioconjchem.1c00283

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Protein Profiling of Breast Carcinomas Reveals Expression of Immune-Suppressive Factors and Signatures Relevant for Patient Outcome

Autor: Felix Ruoff, Nicolas Kersten, Nicole Anderle, Sandra Jerbi, Aaron Stahl, André Koch, Annette Staebler, Andreas Hartkopf, Sara Y. Brucker, Markus Hahn, Katja Schenke-Layland, Christian Schmees, Markus F. Templin

Publikováno v: Cancers; Volume 14; Issue 18; Pages: 4542

In cancer, the complex interplay between tumor cells and the tumor microenvironment results in the modulation of signaling processes. By assessing the expression of a multitude of proteins and protein variants in cancer tissue, wide-ranging informati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0cf3bccfa64e1b0d8bc5d13772acff
https://pubmed.ncbi.nlm.nih.gov/36139700

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Multiplexed Serum Antibody Screening Platform Using Virus Extracts from Endemic Coronaviridae and SARS-CoV-2

Publikováno v: ACS infectious Diseases
ACS Infectious Diseases

The presence of antibodies against endemic coronaviruses has been linked to disease severity after SARS-CoV-2 infection. Assays capable of concomitantly detecting antibodies against endemic coronaviridae such as OC43, 229E, NL63, and SARS-CoV-2 may h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706a00a9a009d83d9eb644b7efbcdee4
https://doi.org/10.1021/acsinfecdis.0c00725

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