Výsledky vyhledávání - "F. Strassheimer"

Akademický článek

AAV-mediated gene transfer of a checkpoint inhibitor in combination with HER2-targeted CAR-NK cells as experimental therapy for glioblastoma

Autor: M.I. Strecker, K. Wlotzka, F. Strassheimer, B. Roller, G. Ludmirski, S. König, J. Röder, C. Opitz, T. Alekseeva, J. Reul, L. Sevenich, T. Tonn, W.S. Wels, J.P. Steinbach, C.J. Buchholz, M.C. Burger

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Glioblastoma (GB) is the most common primary brain tumor, which is characterized by low immunogenicity of tumor cells and prevalent immunosuppression in the tumor microenvironment (TME). Targeted local combination immunotherapy is a promising strateg

Externí odkaz: https://doaj.org/article/94d82fff92f741b8ae2df7293f6ae1d4

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Akademický článek

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OS06.2A Local immunotherapy of glioblastoma via AAV-mediated gene transfer of checkpoint inhibitors in combination with CAR-NK cells

Autor: M I Strecker, F Strassheimer, Winfried S. Wels, Joachim P. Steinbach, J Reul, Michael C. Burger, Christian J. Buchholz, Patrick N. Harter, K Wlotzka, Torsten Tonn

Publikováno v: Neuro Oncol

BACKGROUND Glioblastoma (GB) is the most common primary brain tumor which is characterized by low immunogenicity of tumor cells and prevalent immunosuppression in the tumor microenvironment (TME). Since expression of PD-L1 on GB cells has been descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997d425cee2c640ec2fb7312b9a1b73d
https://doi.org/10.1093/neuonc/noab180.026

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P06.13 A novel local treatment approach? Targeted immunotherapy of glioblastoma via AAV-mediated gene transfer of checkpoint inhibitors through locally administered HER2-AAVs in combination with CAR-NK cells

Autor: Joachim P. Steinbach, Winfried S. Wels, Patrick N. Harter, Christian J. Buchholz, J Reul, Michael C. Burger, F Strassheimer, Torsten Tonn, M I Strecker

Publikováno v: E-Poster Presentations.

Glioblastoma (GB) is the most common primary brain tumor which is characterized by a low immunogenicity of tumor cells and a prevalent immunosuppression in the tumor microenvironment (TME). Since expression of PD-L1 on GB cells has been described, im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd1b80a76361c6309d97bf1efdd5410e
https://doi.org/10.1136/jitc-2020-itoc7.92

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P06.12 Combination therapy of CAR-NK-cells and anti-PD-1 antibody results in high efficacy against advanced-stage glioblastoma in a syngeneic mouse model and induces protective anti-tumor immunity in vivo

Autor: Winfried S. Wels, M C Demes, M I Strecker, Tijna Alekseeva, Lisa Sevenich, IC Mildenberger, Peter J. Wild, Michael C. Burger, Karl-Heinz Plate, Joachim P. Steinbach, Jadranka Macas, Yvonne Reiss, F Strassheimer, Patrick N. Harter, Torsten Tonn

Publikováno v: E-Poster Presentations.

Background Checkpoint inhibitors as well as adoptive cell therapy hold great promise for cancer therapy and encouraging treatment responses have already been demonstrated in different cancer indications. Glioblastoma (GB) is the most common and aggre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44ebb4230997415ccc47355243341c50
https://doi.org/10.1136/jitc-2020-itoc7.91

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OS12.6.A Combination therapy of CAR-NK-cells and anti-PD-1 results in high efficacy against advanced-stage glioblastoma in a syngeneic mouse model and induces protective anti-tumor immunity in vivo

Autor: Michael C. Burger, Winfried S. Wels, Patrick N. Harter, Yvonne Reiss, Iris Mildenberger, Peter J. Wild, Karl-Heinz Plate, Joachim P. Steinbach, M I Strecker, Tijna Alekseeva, M C Demes, Jadranka Macas, F Strassheimer, Torsten Tonn, Lisa Sevenich

Publikováno v: Neuro-Oncology. 23:ii15-ii15

INTRODUCTION Checkpoint inhibitors as well as adoptive cell therapy hold promise for cancer therapy and encouraging treatment responses have already been demonstrated in different cancer indications. Glioblastoma (GB) is the most common and aggressiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ec7eb3e7639837106d2e549ab0f1fe8
https://doi.org/10.1093/neuonc/noab180.049

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Akademický článek

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P04.21 Combination therapy of CAR-NK cells and anti-PD-1 antibody displays potent efficacy against late-stage Glioblastoma and induces protective antitumor immunity

Autor: Michael C. Burger, Patrick N. Harter, Iris C. Mildenberger, F Strassheimer, Congcong Zhang, Winfried S. Wels, Torsten Tonn, Joachim P. Steinbach

BACKGROUND: Checkpoint inhibitors as well as adoptive cell therapy hold great promise for cancer treatment and promising treatment responses have already been demonstrated in different cancer indications. Glioblastoma (GBM) is the most common and agg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd625f3556f705a2c4b702cf71557727
https://europepmc.org/articles/PMC6144362/

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P12.04 Synergistic effects of combination therapy of CAR-NK cells and anti-PD-1 antibody result in high efficacy against advanced stage orthotopic glioblastoma grafts in a syngeneic mouse model and induce protective anti-tumor immunity in vivo

Autor: Joachim P. Steinbach, M I Strecker, Patrick N. Harter, Congcong Zhang, F Strassheimer, Winfried S. Wels, Michael C. Burger, Iris C. Mildenberger, Torsten Tonn

Publikováno v: Neuro Oncol

BACKGROUND Checkpoint inhibitors as well as adoptive cell therapy hold great promise for cancer treatment and encouraging treatment responses have already been demonstrated in different cancer indications. Glioblastoma (GB) is the most common and agg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c440a22440568370e0c9d75097ee72
https://doi.org/10.1093/neuonc/noz126.215

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Akademický článek

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