Zobrazeno 1 - 10
of 45
pro vyhledávání: '"F. Sorgi"'
Publikováno v:
Methods in molecular medicine. 7
Development of safe and effective technology for delivering functional DNA into cells in an intact organism is crucial to broad applications of gene therapy to human disease. Both viral and nonviral vectors have been developed. Of the technologies cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::628f9698ac3f5a777ad474b62ee6e11f
https://pubmed.ncbi.nlm.nih.gov/24493437
https://pubmed.ncbi.nlm.nih.gov/24493437
Autor:
Natasha J. Caplen, Peter G. Middleton, F. Sorgi, Duncan M. Geddes, Leaf Huang, M Stern, SJ Farr, DC Gruenert, JE Browning, C Hughes, Ewfw Alton
Publikováno v:
Gene Therapy. 5:583-593
Nebulisation is currently the most acceptable and practical delivery system for repeated applications of gene therapy to the lower airways of cystic fibrosis (CF) patients. We have assessed whether this route of administration offers other benefits w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc31e9a2b2f07e9c4df09fe512fdb5d
https://doi.org/10.1038/sj.gt.3300629
https://doi.org/10.1038/sj.gt.3300629
Autor:
M Stern, Felix M. Munkonge, Leaf Huang, Natasha J. Caplen, T. Pitt, Ann Dewar, Andrew Bush, Duncan M. Geddes, Eric W.F.W. Alton, Jane C. Davies, F. Sorgi
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 16:657-663
Much of the morbidity and mortality seen in cystic fibrosis (CF) is related to chronic infection of the respiratory tract with Pseudomonas aeruginosa. Some studies have attributed the strong relationship between CF and Pseudomonas colonization to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6096afd319b52e3b1953065ab19e6dd
https://doi.org/10.1165/ajrcmb.16.6.9191467
https://doi.org/10.1165/ajrcmb.16.6.9191467
Autor:
William H. Colledge, Martin J. Evans, Gooi Hc, Leaf Huang, Egan Jj, SE Smyth, C. A. Goddard, Deborah R. Gill, A K Webb, EM Fitzjohn, F. Sorgi, Alan W. Cuthbert, BE Waddell, KA Mofford, Uzi Gileadi, Kevin W Southern, S C Hyde, Hannavy K, Christopher F. Higgins
Publikováno v:
Scopus-Elsevier
The major cause of mortality in patients with cystic fibrosis (CF) is lung disease. Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene product in the airways is a potential treatment. Clinical studies in which the CFTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ada3d9294e8e0030f90718fff79b99d
https://pubmed.ncbi.nlm.nih.gov/10918483
https://pubmed.ncbi.nlm.nih.gov/10918483
Autor:
P, Leone, C G, Janson, L, Bilaniuk, Z, Wang, F, Sorgi, L, Huang, R, Matalon, R, Kaul, Z, Zeng, A, Freese, S W, McPhee, E, Mee, M J, During, L, Bilianuk
Publikováno v:
Annals of neurology. 48(1)
With the ultimate goal of developing safe and effective in vivo gene therapy for the treatment of Canavan disease and other neurological disorders, we developed a non-viral lipid-entrapped, polycation-condensed delivery system (LPD) for central nervo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a56abdeb557a286a6b7a104348fdfbcd
https://pubmed.ncbi.nlm.nih.gov/10894210
https://pubmed.ncbi.nlm.nih.gov/10894210
Autor:
Leaf Huang, Ronald G. Crystal, F. Sorgi, JE Browning, C Marriot, Ewfw Alton, Duncan M. Geddes, Dieter C. Gruenert, Natasha J. Caplen, M Stern, Uta Griesenbach
Publikováno v:
Gene therapy. 5(1)
Trials of gene transfer for cystic fibrosis (CF) are currently underway. However, direct application to the airways may be impeded by the presence of airway secretions. We have therefore assessed the effect of CF sputum on the expression of the repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ed8edcc2218c4f4c8b39fc6691d2e9
https://pubmed.ncbi.nlm.nih.gov/9536269
https://pubmed.ncbi.nlm.nih.gov/9536269
The effect of cationic liposome pretreatment and centrifugation on retrovirus-mediated gene transfer
Publikováno v:
Gene therapy. 4(12)
Pretreatment of retroviral supernatants with the cationic liposomes DOTMA-DOPE (Lipofectin), DC-Chol-DOPE and DOSPA-DOPE (Lipofectamine) was found to enhance static transductions of TF-1 target cells. The relative effectiveness at increasing transduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d63aeaaa7f730270ffa47ce49829c6
https://pubmed.ncbi.nlm.nih.gov/9472562
https://pubmed.ncbi.nlm.nih.gov/9472562
Publikováno v:
Gene therapy. 4(9)
A polycationic peptide, protamine sulfate, USP, has been shown to be able to condense plasmid DNA efficiently for delivery into several different types of cells in vitro by several different types of cationic liposomes. The monovalent cationic liposo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5282d0a6f387cafbfb0a7376a47f4b
https://pubmed.ncbi.nlm.nih.gov/9349433
https://pubmed.ncbi.nlm.nih.gov/9349433
Autor:
Stephen C. Hyde, William H. Colledge, L J MacVinish, Mathew J. Evans, Peter G. Middleton, Leaf Huang, D Bilton, K A Mofford, A K Webb, K W Southern, Alan W. Cuthbert, Christopher F. Higgins, A Thomson, Deborah R. Gill, D J Lane, T Seddon, J M Littlewood, F. Sorgi, Rosemary Ratcliff
Publikováno v:
Scopus-Elsevier
Cystic fibrosis (CF) is a common, serious, inherited disease. The major cause of mortality in CF is lung disease, due to the failure of airway epithelial cells to express a functional product of the cystic fibrosis transmembrane conductance regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a81aea28b967dd9731fa22f18674eca
http://ora.ox.ac.uk/objects/uuid:2ecbb1ee-fe1b-4df8-a132-8528de9048e4
http://ora.ox.ac.uk/objects/uuid:2ecbb1ee-fe1b-4df8-a132-8528de9048e4
Publikováno v:
Gene therapy. 3(7)
The human interleukin-2 (IL-2) gene was successfully delivered into established human tumor xenografts in SCID (severe combined immunodeficient) mice by cationic liposome-mediated DNA delivery. A bicistronic mammalian expression vector containing a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3909a5f592a3d3d50154ee22c2d4da1e
https://pubmed.ncbi.nlm.nih.gov/8818648
https://pubmed.ncbi.nlm.nih.gov/8818648