Výsledky vyhledávání - "F. S. Zarudii"

QSAR Modelling of Thymidylate Synthase Inhibitors in a Series of Quinazoline Derivatives

Autor: F. S. Zarudii, V. R. Khairullina, A. Ya. Gerchikov, Alexey Lagunin

Publikováno v: Pharmaceutical Chemistry Journal. 51:884-888

Thymidylate synthase (ThS) is a target for antimetabolite antitumor drugs. Such drugs have been used in the clinic although they cause several severe side effects and accumulate in tissues. Therefore, new less toxic ThS inhibitors must be sought and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4db830d973b0e011b1e751aad2e2c51
https://doi.org/10.1007/s11094-018-1710-z

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Effects of novel hexahydropyrimidine derivatives as potential ligands of M1 muscarinic acetylcholine receptor on cognitive function, hypoxia-induced lethality, and oxidative stress in rodents

Autor: N.N. Gibadullina, Sergey L. Khursan, T. A. Sapozhnikova, R. Yu. Khisamutdinova, D.R. Kireeva, S. F. Gabdrakhmanova, N. S. Makara, F. S. Zarudii, Sophia S. Borisevich

Publikováno v: Behavioural brain research. 373

The neurodegenerative diseases have a complex pathogenetic mechanism comprising oxidative stress and receptor system dysfunction caused by various damaging factors such as, for example, brain hypoxia. The purpose of this study was to elucidate the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d37f28785fb50fe805c497137307c95
https://pubmed.ncbi.nlm.nih.gov/31340175

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Composition and Pharmacological Activity of Neutral Lipids from Rhizomes with Roots of the Introduced Plants Helleborus abchasicus and H. caucasicus

Autor: N. S. Makara, F. S. Zarudii, S. S. Lyashenko, R. Yu. Khisamutdinova, T. A. Sapozhnikova, S. G. Yunusova, M. S. Yunusov, S. F. Gabdrakhmanova, O. N. Denisenko, Z. V. Ishchenko

Publikováno v: Chemistry of Natural Compounds. 52:973-978

The compositions of neutral lipids (NL) and fatty acids (FA) from subterranean parts of the introduced plants Helleborus abchasicus and H. caucasicus (Ranunculaceae) were established and compared with those of the wild species. The FA from diacyl- an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1011eb5d089e64f893688475b480134e
https://doi.org/10.1007/s10600-016-1839-5

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Synthesis and Hypoglycemic Activity of 11-Deoxoglycyrrhetic Acid Derivatives

Autor: A. S. Budaev, N. S. Makara, Leonid V. Spirikhin, F. S. Zarudii, Baltina Lidiya A, L. R. Mikhailova

Publikováno v: Chemistry of Natural Compounds. 52:441-444

New 2-hydroxy-1-en-3-ones were prepared by oxidation of 11-deoxoglycyrrhetic acid 3-oxo-derivatives and its 30-methyl ester by atmospheric oxygen in the presence of t-BuOK. 2-Hydroxy-3-oxo-18βH-olean-1,12-dien-30-oic acid at a dose of 50 mg/kg reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8924ce4c203ef1903bc124c44e1ab703
https://doi.org/10.1007/s10600-016-1668-6

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Antihypoxic Activity of Several Scaffold Derivatives of Quinopimaric Acid

Autor: A. R. Uzbekov, N. S. Makara, F. Z. Galin, S. F. Gabdrakhmanova, F. S. Zarudii, G. F. Vafina

Publikováno v: Chemistry of Natural Compounds. 52:82-85

The antihypoxic activity of a series of quinopimaric acid scaffold derivatives was studied. It was shown that compounds 3, 5, and 8 increased the lifespan of mice in various hypoxia models.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5f7fdd6500de1ac3d1948164d0ebf49
https://doi.org/10.1007/s10600-016-1552-4

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Search for Nootropic Substances Based on Molecular Docking of Methanepyrido[1,2-a][1, 5]Diazocin[(-)-Cytisine] Derivatives to the Active Center of the Nicotinic Acetylcholine Receptor

Autor: F. S. Zarudii, A. Ya. Gerchikov, Inna P. Tsypysheva, V. R. Khairullina, M. N. Vasil’ev

Publikováno v: Pharmaceutical Chemistry Journal. 49:582-586

Docking of a series of methanepyrido[1,2-a][1,5]diazocin[(-)-cytisine derivatives to the active center of the nicotinic acetylcholine receptor was used to generate a set of potential substances for the treatment of cognitive dysfunction. The results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1bdbd266081ad38f39b3da8b6f928e8
https://doi.org/10.1007/s11094-015-1333-6

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Hepatoprotective and Choleretic Properties of Levopimaric Acid Derivatives

Autor: N. S. Makara, S. F. Gabdrakhmanova, T. A. Sapozhnikova, R. Yu. Khisamutdinova, A. R. Uzbekov, F. S. Zarudii, G. F. Vafina

Publikováno v: Pharmaceutical Chemistry Journal. 51:348-350

The hepatoprotective and choleretic activities of three levopimaric acid derivatives were studied experimentally using a CCl4-induced acute hepatitis model in rats. It was established that all investigated levopimaric acid derivatives tended to incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbe22637825ebef7afc8c3800c1e683d
https://doi.org/10.1007/s11094-017-1612-5

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Anti-Inflammatory Activity of Novel 12-N-methylcytisine Derivatives

Autor: Sergey L. Khursan, P. R. Petrova, F. S. Zarudii, Yulia V. Vakhitova, Nina S Makara, L. F. Zainullina, Sophia S. Borisevich, A. V. Koval’skaya, Inna P. Tsypysheva

Publikováno v: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 16

Background and objectives Neurodegenerative diseases and inflammation are always linked to each other; therefore the elaboration of new chemical compounds, which interact with pharmacological targets involved into these two processes, can become one

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https://doi.org/10.2174/1871523016666170616115252

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