Zobrazeno 1 - 10 of 357 pro vyhledávání: '"F. S. Zarudii"'
1
Variation of spacer type and topology of phenyl moiety in 2-pyridone core of 4-oxo-3-N-methylcytisine; effect of synthesized compounds on rat’s behavior in conditioned passive avoidance reflex (CPAR) test
Autor: T. A. Sapozhnikova, A. V. Koval’skaya, Inna P. Tsypysheva, P. R. Petrova, Alexander N. Lobov, N. S. Makara, F. S. Zarudii, S. F. Gabdrakhmanova
Publikováno v: Natural Product Research. 35:207-215
Novel derivatives of 4-oxo-3-methylcytisine with phenyl moiety bonded to starting molecule through various spacers were obtained from the 9-amino, -halo, -formyl and 11-halo precursors by reductive alkylation of amines, generation of amide, as well a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c8d36eebc06ac4473dc226442f69f2e
https://doi.org/10.1080/14786419.2019.1622106
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2
Nootropic Activity of a Novel (-)-Cytisine Derivative (3aR,4S,8S,12R, 12aS,12bR)-10-Methyl-2-Phenyloctahydro-1H-4,12a-Etheno-8,12-Methanopyrrolo[3’,4’:3,4]Pyrido[1,2-a] [1,5]Diazocine-1,3,5(4H)-Trione
Autor: P. R. Petrova, N. S. Makara, F. S. Zarudii, Sophia S. Borisevich, C L. Khursan, R. Yu. Khisamutdinova, T. A. Sapozhnikova, Inna P. Tsypysheva, A. V. Koval’skaya
Publikováno v: Bulletin of Experimental Biology and Medicine. 164:434-438
We performed screening of nootropic properties of 10 new derivatives of quinolizidine alkaloid (-)-cytisine. Compounds with β-endo stereochemistry were more active than α-endo-isomers. Under stress conditions (3aR,4S,8S,12R,12aS,12bR)-10-methyl-2-p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93d04e39d5b6ae9cf329a88e2f8b25f
https://doi.org/10.1007/s10517-018-4006-0
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3
QSAR Modelling of Thymidylate Synthase Inhibitors in a Series of Quinazoline Derivatives
Autor: F. S. Zarudii, V. R. Khairullina, A. Ya. Gerchikov, Alexey Lagunin
Publikováno v: Pharmaceutical Chemistry Journal. 51:884-888
Thymidylate synthase (ThS) is a target for antimetabolite antitumor drugs. Such drugs have been used in the clinic although they cause several severe side effects and accumulate in tissues. Therefore, new less toxic ThS inhibitors must be sought and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4db830d973b0e011b1e751aad2e2c51
https://doi.org/10.1007/s11094-018-1710-z
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4
Effects of novel hexahydropyrimidine derivatives as potential ligands of M1 muscarinic acetylcholine receptor on cognitive function, hypoxia-induced lethality, and oxidative stress in rodents
Autor: N.N. Gibadullina, Sergey L. Khursan, T. A. Sapozhnikova, R. Yu. Khisamutdinova, D.R. Kireeva, S. F. Gabdrakhmanova, N. S. Makara, F. S. Zarudii, Sophia S. Borisevich
Publikováno v: Behavioural brain research. 373
The neurodegenerative diseases have a complex pathogenetic mechanism comprising oxidative stress and receptor system dysfunction caused by various damaging factors such as, for example, brain hypoxia. The purpose of this study was to elucidate the in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d37f28785fb50fe805c497137307c95
https://pubmed.ncbi.nlm.nih.gov/31340175
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5
Composition and Pharmacological Activity of Neutral Lipids from Rhizomes with Roots of the Introduced Plants Helleborus abchasicus and H. caucasicus
Autor: N. S. Makara, F. S. Zarudii, S. S. Lyashenko, R. Yu. Khisamutdinova, T. A. Sapozhnikova, S. G. Yunusova, M. S. Yunusov, S. F. Gabdrakhmanova, O. N. Denisenko, Z. V. Ishchenko
Publikováno v: Chemistry of Natural Compounds. 52:973-978
The compositions of neutral lipids (NL) and fatty acids (FA) from subterranean parts of the introduced plants Helleborus abchasicus and H. caucasicus (Ranunculaceae) were established and compared with those of the wild species. The FA from diacyl- an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1011eb5d089e64f893688475b480134e
https://doi.org/10.1007/s10600-016-1839-5
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6
Synthesis and Hypoglycemic Activity of 11-Deoxoglycyrrhetic Acid Derivatives
Autor: A. S. Budaev, N. S. Makara, Leonid V. Spirikhin, F. S. Zarudii, Baltina Lidiya A, L. R. Mikhailova
Publikováno v: Chemistry of Natural Compounds. 52:441-444
New 2-hydroxy-1-en-3-ones were prepared by oxidation of 11-deoxoglycyrrhetic acid 3-oxo-derivatives and its 30-methyl ester by atmospheric oxygen in the presence of t-BuOK. 2-Hydroxy-3-oxo-18βH-olean-1,12-dien-30-oic acid at a dose of 50 mg/kg reduc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8924ce4c203ef1903bc124c44e1ab703
https://doi.org/10.1007/s10600-016-1668-6
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7
Antihypoxic Activity of Several Scaffold Derivatives of Quinopimaric Acid
Autor: A. R. Uzbekov, N. S. Makara, F. Z. Galin, S. F. Gabdrakhmanova, F. S. Zarudii, G. F. Vafina
Publikováno v: Chemistry of Natural Compounds. 52:82-85
The antihypoxic activity of a series of quinopimaric acid scaffold derivatives was studied. It was shown that compounds 3, 5, and 8 increased the lifespan of mice in various hypoxia models.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5f7fdd6500de1ac3d1948164d0ebf49
https://doi.org/10.1007/s10600-016-1552-4
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8
Search for Nootropic Substances Based on Molecular Docking of Methanepyrido[1,2-a][1, 5]Diazocin[(-)-Cytisine] Derivatives to the Active Center of the Nicotinic Acetylcholine Receptor
Autor: F. S. Zarudii, A. Ya. Gerchikov, Inna P. Tsypysheva, V. R. Khairullina, M. N. Vasil’ev
Publikováno v: Pharmaceutical Chemistry Journal. 49:582-586
Docking of a series of methanepyrido[1,2-a][1,5]diazocin[(-)-cytisine derivatives to the active center of the nicotinic acetylcholine receptor was used to generate a set of potential substances for the treatment of cognitive dysfunction. The results
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1bdbd266081ad38f39b3da8b6f928e8
https://doi.org/10.1007/s11094-015-1333-6
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9
Hepatoprotective and Choleretic Properties of Levopimaric Acid Derivatives
Autor: N. S. Makara, S. F. Gabdrakhmanova, T. A. Sapozhnikova, R. Yu. Khisamutdinova, A. R. Uzbekov, F. S. Zarudii, G. F. Vafina
Publikováno v: Pharmaceutical Chemistry Journal. 51:348-350
The hepatoprotective and choleretic activities of three levopimaric acid derivatives were studied experimentally using a CCl4-induced acute hepatitis model in rats. It was established that all investigated levopimaric acid derivatives tended to incre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbe22637825ebef7afc8c3800c1e683d
https://doi.org/10.1007/s11094-017-1612-5
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10
Anti-Inflammatory Activity of Novel 12-N-methylcytisine Derivatives
Autor: Sergey L. Khursan, P. R. Petrova, F. S. Zarudii, Yulia V. Vakhitova, Nina S Makara, L. F. Zainullina, Sophia S. Borisevich, A. V. Koval’skaya, Inna P. Tsypysheva
Publikováno v: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 16
Background and objectives Neurodegenerative diseases and inflammation are always linked to each other; therefore the elaboration of new chemical compounds, which interact with pharmacological targets involved into these two processes, can become one
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15be6ee5e6249ba00792c9d7155f6f98
https://doi.org/10.2174/1871523016666170616115252
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