Výsledky vyhledávání - "F. S. Waksmunski"

Radical-Induced Oxidation of Oxahydrindene (Hexahydrobenzofuran) Portion of 22,23-Dihydroavermectin B1a: Identification of Autooxidation Products

Autor: James V. Pivnichny, Helmut Mrozik, John D. Stong, F. S. Waksmunski

Publikováno v: Journal of Pharmaceutical Sciences. 81:1000-1003

Three products resulting from free-radical-induced oxidation of the oxahydrindene portion of 22,23-dihydroavermectin B1a (H2B1a) are 5-oxo-H2B1a, 8a-oxo-H2B1a, and 5,8a-bisoxo-H2B1a. The last of these compounds has not been reported previously.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c93e349acd007c33c71b8602cbcc148
https://doi.org/10.1002/jps.2600811008

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An unusual twist in the synthesis and hydrolysis of the 23,24-epoxide of 22,23-dihydroavermectin B1a

Autor: Mark A. Holmes, F. S. Waksmunski, Bryon H. Arison, George A. Doss, Michael H. Fisher, Helmut Mrozik, Thomas L. Shih

Publikováno v: Tetrahedron Letters. 33:1709-1712

Treatment of 4″,5-di-O-tert-butyldimethylsilyl(or phenoxyacetyl)-7-O-trimethylsilyl-avermectin B 2a ( 1a,b ) with diethylaminosulfur trifluoride (DAST) at 20AC in dichloromethane resulted in net elimination of water to yield 65% of the 23,24-olefin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6f55e80bed989878ba27b57eab39b8b
https://doi.org/10.1016/s0040-4039(00)91712-x

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Benzylated 1,2,3-triazoles as anticoccidiostats

Autor: F. S. Waksmunski, Thomas R. Beattie, Jeannette E. Brown, Donald W. Graham, L. H. Peterson, Richard J. Bochis, E E Harris, Louis Barash, M Tischler, John C. Chabala

Publikováno v: Journal of medicinal chemistry. 34(9)

Substituted 5-amino-4-carbamoyl-1,2,3-triazoles 3a-w were prepared by two synthetic schemes and evaluated in vivo for anticoccidial activity. Both schemes proceeded by brominating appropriately substituted toluenes 4a-s,v to 5a-s,v. In Scheme I, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a22c707742be1f4ad55f77c6d3fbdb
https://pubmed.ncbi.nlm.nih.gov/1895303

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Substituted imidazo[1,2-a]pyridine-2-carbamate anthelmintics

Autor: P. Eskola, Helmut Mrozik, G. Olson, F. S. Waksmunski, Peter Kulsa, Richard J. Bochis, L. E. Olen, Egerton, G. Wilks, J.E. Taylor, Dan A. Ostlind

Publikováno v: Journal of Medicinal Chemistry. 24:1518-1521

Anthelmintic efficacies of a series of 6-substituted methyl imidazo[1,2-alpha]pyridine-2-carbamates were compared to similarly substituted benzimidazole-2-carbamates. With only one exception, methyl 6-benzoylimidazo[1,2-alpha]pyridine-2-carbamate, bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8cec27505ceaa1e2a6c1ea934d3a7fe
https://doi.org/10.1021/jm00144a030

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A series of pyromellitic diimides that improve the efficiency of rumen fermentation

Autor: Bruce O. Linn, Lynn M. Paege, Patrick J. Doherty, F. S. Waksmunski, Peter Kulsa, Richard J. Bochis, Michael H. Fisher

Publikováno v: Journal of Agricultural and Food Chemistry. 30:1236-1242

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::434cf7f4345ffe19527c42494b51b6e6
https://doi.org/10.1021/jf00114a058

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Synthesis of milbemycins from avermectins

Autor: Alexander R Matzuk, Helmut Mrozik, M. H. Fisher, Mary F. Woods, John C. Chabala, F. S. Waksmunski, P. Eskola

Publikováno v: Tetrahedron Letters. 24:5333-5336

The structure of the avermectins and the milbemycins were interrelated by the conversion of 22,23-dihydroavermectin B1a and B1b aglycones (4) into 13-deoxy-22,23-dihydroavermectin B1a aglycone (9) and 13-deoxy-22,23-dihydroavermectin B1b aglycone (11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::732fec8186a79d0d27394b4cc31abc69
https://doi.org/10.1016/s0040-4039(00)87861-2

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