Výsledky vyhledávání - "F. S. Davies"

Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts

Autor: David J. G. White, D J Ostlie, Peter J. Friend, Emanuele Cozzi, Bhatti Farah, Gilda Chavez, Conrad M. Vial, Martin Goddard, Kenneth G. C. Smith, Sathia Thiru, Hugh F. S. Davies, John Wallwork, John Bradley

Publikováno v: Xenotransplantation. 10:300-310

To date, the best results in life-supporting pig-to-primate renal xenotransplantation have been obtained in recipients exposed to long-term immunosuppression with cyclophosphamide. As this agent is frequently associated with side-effects, we have exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fb0f181ea478601a49d23333ce3ecc5
https://doi.org/10.1034/j.1399-3089.2003.02014.x

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Removal of anti-Galα1,3Gal xenoantibodies with an injectable polymer

Autor: Andreas Katopodis, Willy Kinzy, Armin Bruelisauer, David P. White, Hugh F. S. Davies, Olivier Kretz, Richard G. Warner, Markus Streiff, Alain Schweitzer, Valérie F. J. Quesniaux, Emanuele Cozzi, Elke Persohn, Rudolf O. Duthaler, Rafael Mañez, Gebhard Thoma, Birgit Dorobek, Hendrik Andres

Publikováno v: Journal of Clinical Investigation. 110:1869-1877

Preformed and elicited Ab's against the Galalpha1,3Gal terminating carbohydrate chains (alphaGal Ab's) are the primary cause of hyperacute and acute vascular xenograft rejection in pig-to-primate transplantation. alphaGal Ab's are produced by long-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cfaab6e337937e34a44c9a87ba22136
https://doi.org/10.1172/jci16526

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Porcine livers perfused with human blood mount a graft-versus-???host??? reaction1

Autor: Eleanor M. Bolton, David J. G. White, Derek G. D. Wight, Peter J. Friend, Andrew J. Butler, Jeremy N. Skepper, Hugh F. S. Davies, Michael Rees

Publikováno v: Transplantation. 73:1460-1467

Background. A major focus of xenotransplantation research is the interaction between human immune effector mechanisms and porcine tissues. We present evidence that a transplanted porcine organ might also mount a significant immune response to a human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::828b9c0d71a1f6c7aad3e522e8d02dcd
https://doi.org/10.1097/00007890-200205150-00016

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Anti-pig antibody levels in naïve baboons and cynomolgus monkeys

Autor: Megan L. Mclaughlin, Henk-Jan Schuurman, Hugh F. S. Davies, Emanuele Cozzi, Beverly J. Holmes, Laura Copeman, Andrew Richards, Michel Awwad

Publikováno v: Xenotransplantation. 9:135-147

Xenoreactive natural antibodies are a major bar-rier to success in the pig-to-primate discordantspecies combination used as a model for pig-to-human xenotransplantation. In nai¨ve recipients,i.e. animals not purposefully immunized to pigtissues, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edc59f892046869c79455a5497cdecf9
https://doi.org/10.1034/j.1399-3089.2002.1o056.x

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Removal of bowel aerobic gram-negative bacteria is more effective than immunosuppression with cyclophosphamide and steroids to decrease natural α-Galactosyl IgG antibodies

Autor: Eduardo Lopez-Pelaez, Manuel Hermida, Inmaculada Díaz, Andreas Katopodis, Francisco J. Blanco, Rafael Mañez, Alberto Centeno, Hugh F. S. Davies

Publikováno v: Xenotransplantation. 8:15-23

Natural α-Galactosyl (Gal) antibodies play an important role in the rejection of pig xenografts by humans and Old World monkeys. In this study we investigate the efficacy of two different strategies to reduce the serum level of natural anti-Gal anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::760efa2bf55a632abfe77b3bce3d5efd
https://doi.org/10.1034/j.1399-3089.2001.00082.x

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Comparison of allogeneic and xenogeneic in vitro T-cell proliferative responses in sensitized patients awaiting kidney transplantation

Autor: Gertie J, Oostingh, Hugh F S, Davies, J Andrew, Bradley, Craig J, Taylor

Publikováno v: Xenotransplantation. 10(6)

Highly sensitized patients awaiting kidney transplantation may be potential candidates for future clinical trials using pig organ donors. Because of crossreactivity between human leucocyte antigens (HLA) and swine leucocyte antigens (SLA), such patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3209b84c6190c50eaa215d1781b0b4f
https://pubmed.ncbi.nlm.nih.gov/14705630

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Potential implications of ABO blood group for vascular rejection in pig to human kidney xenotransplantation

Autor: Gertie J, Oostingh, Hugh F S, Davies, Barbara N, Arch, J Andrew, Bradley, Craig J, Taylor

Publikováno v: Xenotransplantation. 10(3)

A substantial hurdle for successful xenotransplantation is to negate the effect of xenoreactive natural antibodies [mainly Galalpha1-3Galbeta1-4GlcNAc (alpha-Gal) specific] that cause hyperacute xenograft rejection. Galalpha1-3Gal molecules (alpha-Ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bef3276e413f3fb7084a40ddc7c57f38
https://pubmed.ncbi.nlm.nih.gov/12694548

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