Zobrazeno 1 - 10
of 25
pro vyhledávání: '"F. Raymond Salemme"'
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/29a90fe13e964c2bb5fe0fcccc5f4723
Autor:
F. Raymond Salemme, Roger F. Bone
Publikováno v:
Structure-Based Drug Design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85f8f6e43bde87d06abfef5d2bf73f97
https://doi.org/10.1201/9780203738023-20
https://doi.org/10.1201/9780203738023-20
Autor:
F Raymond Salemme
Publikováno v:
Pharmacogenomics. 4:257-267
Chemical genomics approaches are evolving to overcome key problems limiting the efficiency of drug discovery in the postgenomic era. Many of these stem from the low success rates in finding drugs for novel genomics targets whose biochemical propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d97bb7dd820b1ba5018e3b15b00de7
https://doi.org/10.1517/phgs.4.3.257.22692
https://doi.org/10.1517/phgs.4.3.257.22692
Publikováno v:
Nature Reviews Drug Discovery. 1:337-346
The multitude of potential drug targets emerging from genome sequencing demands new approaches to drug discovery. A chemogenomics strategy, which involves the generation of small-molecule compounds that can be used both as tools to probe biological m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfb8844a00d46f80dd8a92194a8855d
https://doi.org/10.1038/nrd791
https://doi.org/10.1038/nrd791
Autor:
F. Raymond Salemme, R. Kyle Palmer, Robert G. Bryant, Tulu Buber, Daniel Long, Francis X. Brennan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 1 (2014)
PLoS ONE, Vol 9, Iss 1 (2014)
The image currently appearing as Figure 10 is incorrect. Please see the correct Figure 10 here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cb8ef0c3b156f01e9958e7f5a7a8b5
http://europepmc.org/articles/PMC3891546
http://europepmc.org/articles/PMC3891546
Autor:
Carl R. Illig, Larry Murphy, Roger F. Bone, Tianbao Lu, Richard M. Soll, F. Raymond Salemme, John C. Spurlino, Bruce E. Tomczuk
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:79-82
The structure–activity relationships of a novel series of non-amide-based thrombin inhibitors are described. Exploration of the P2 and the aryl binding region for this series has identified optimal groups for achieving nanomolar potency. The bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8157e82d3b892ad1187077c6e3827196
https://doi.org/10.1016/s0960-894x(99)00617-4
https://doi.org/10.1016/s0960-894x(99)00617-4
Autor:
Robert G. Bryant, Daniel Long, Tulu Buber, Francis X. Brennan, F. Raymond Salemme, R. Kyle Palmer
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e72391 (2013)
PLoS ONE, Vol 8, Iss 8, p e72391 (2013)
Taste quality and palatability are two of the most important properties measured in the evaluation of taste stimuli. Human panels can report both aspects, but are of limited experimental flexibility and throughput capacity. Relatively efficient anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874cb961d2eb562a958e642800aa62fb
http://europepmc.org/articles/PMC3741146
http://europepmc.org/articles/PMC3741146
Autor:
F. Raymond Salemme, Tianbao Lu, John C. Spurlino, Richard M. Soll, Bruce E. Tomczuk, Carl R. Illig, Roger F. Bone, Larry Murphy
Publikováno v:
ChemInform. 31
The structure–activity relationships of a novel series of non-amide-based thrombin inhibitors are described. Exploration of the P2 and the aryl binding region for this series has identified optimal groups for achieving nanomolar potency. The bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca1e5586c929de4ecc8e337a56bae722
https://doi.org/10.1002/chin.200018096
https://doi.org/10.1002/chin.200018096
Autor:
Tianobao Lu, Stephen H. Eisennagel, Larry Murphy, Roger F. Bone, F. Raymond Salemme, Carl R. Illig, John C. Spurlino, Richard Soll, Bruce E. Tomczuk, Fedde Cynthia L
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccfb6ebaed9c9c303ace4f8c59b2844c
https://doi.org/10.1002/chin.200018172
https://doi.org/10.1002/chin.200018172
Autor:
Alexander McPherson, Garry L. Taylor, Wilson Smith, S. Koszelak, L.L. Clancy, Daniel C. Carter, Kenneth L. Powell, Charles E. Bugg, Shobha E. Senadhi, Steven E. Ealick, Graham Darby, F. Raymond Salemme, Tattanahalli L. Nagabhushan, David K. Stammers, Douglas H. Ohlendorf, George S. Nelson, H.M. Einspahr, Brian M. McKeever, Robert S. Snyder, Craig D. Smith, Lawrence J. DeLucas, Manuel A. Navia, Patricia C. Weber, Senadhi Vijay-Kumar
Publikováno v:
Journal of Crystal Growth. 110:302-311
Recent advances in protein crystallography have significantly shortened the time and labor required to determine the three-dimensional structures of macromolecules once good crystals are available. Crystal growth has become a major bottleneck in furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6b982afa58f2e99aa8936cf41a34190
https://doi.org/10.1016/0022-0248(91)90899-g
https://doi.org/10.1016/0022-0248(91)90899-g