Severity, predictors and clinical correlates of post-COVID syndrome (PCS) in Germany: A prospective, multi-centre, population-based cohort study

Autor: Thomas Bahmer, Christoph Borzikowsky, Wolfgang Lieb, Anna Horn, Lilian Krist, Julia Fricke, Carmen Scheibenbogen, Klaus F. Rabe, Walter Maetzler, Corina Maetzler, Martin Laudien, Derk Frank, Sabrina Ballhausen, Anne Hermes, Olga Muljukov, Karl Georg Haeusler, Nour Eddine El Mokhtari, Martin Witzenrath, Jörg Janne Vehreschild, Dagmar Krefting, Daniel Pape, Felipe A. Montellano, Mirjam Kohls, Caroline Morbach, Stefan Störk, Jens-Peter Reese, Thomas Keil, Peter Heuschmann, Michael Krawczak, Stefan Schreiber

Publikováno v: EClinicalMedicine, Vol 51, Iss , Pp 101549- (2022)

Summary: Background: Post-COVID syndrome (PCS) is an important sequela of COVID-19, characterised by symptom persistence for >3 months, post-acute symptom development, and worsening of pre-existing comorbidities. The causes and public health impact o

Externí odkaz: https://doaj.org/article/7641c051e8cd443b85c2da10ed36efbe

Composite endpoints in COPD: clinically important deterioration in the UPLIFT trial

Autor: Klaus F. Rabe, David M. G. Halpin, MeiLan K. Han, Marc Miravitlles, Dave Singh, Lars Grönke, Florian Voß, Fernando J. Martinez

Publikováno v: Respiratory Research, Vol 21, Iss 1, Pp 1-10 (2020)

Abstract Background Assessments of lung function, exacerbations and health status are common measures of chronic obstructive pulmonary disease (COPD) progression and treatment response in clinical trials. We hypothesised that a composite endpoint cou

Externí odkaz: https://doaj.org/article/f39365604a5449388ba1c0782fbe4ed5

High inhaler resistance does not limit successful inspiratory maneuver among patients with asthma or COPD

Autor: Ville A Vartiainen, Federico Lavorini, Anna C Murphy, Klaus F Rabe

Publikováno v: Expert Opinion on Drug Delivery. 20:385-393

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9475900e140380829d4c739148c699f
https://doi.org/10.1080/17425247.2023.2179984

Benefits of Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate on COPD Exacerbations, Lung Function, Symptoms, and Quality of Life Across Blood Eosinophil Ranges: A Post-Hoc Analysis of Data from ETHOS

Autor: Mona Bafadhel, Klaus F Rabe, Fernando J Martinez, Dave Singh, Patrick Darken, Martin Jenkins, Magnus Aurivillius, Mehul Patel, Paul Dorinsky

Publikováno v: Bafadhel, M, Rabe, K F, Martinez, F J, Singh, D, Darken, P, Jenkins, M, Aurivillius, M, Patel, M & Dorinsky, P 2022, ' Benefits of Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate on COPD Exacerbations, Lung Function, Symptoms, and Quality of Life Across Blood Eosinophil Ranges : A Post-Hoc Analysis of Data from ETHOS ', International journal of chronic obstructive pulmonary disease, vol. 17, pp. 3061-3073 . https://doi.org/10.2147/COPD.S374670

Mona Bafadhel,1 Klaus F Rabe,2 Fernando J Martinez,3 Dave Singh,4 Patrick Darken,5 Martin Jenkins,6 Magnus Aurivillius,7 Mehul Patel,6 Paul Dorinsky8 1Department of Immunobiology, School of Immunology and Microbial Sciences, Faculty of Life Sciences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08dc180daecfc1a022a94f7792085965
https://doi.org/10.2147/copd.s374670

Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis

Autor: Torsten Goldmann, Gernot Zissel, Henrik Watz, Daniel Drömann, Martin Reck, Christian Kugler, Klaus F. Rabe, Sebastian Marwitz

Publikováno v: Respiratory Research, Vol 19, Iss 1, Pp 1-13 (2018)

Abstract Background The origin of collagen-producing cells in lung fibrosis is unclear. The involvement of embryonic signaling pathways has been acknowledged and trans-differentiation of epithelial cells is discussed critically. The work presented he

Externí odkaz: https://doaj.org/article/2103804e60dd4fa7826d29227f83a0b3