Výsledky vyhledávání

Induction of apoptosis in oral cancer cells by an anti-bcl-2 ribozyme delivered by an adenovirus vector

Autor: S A, Gibson, C, Pellenz, R E, Hutchison, F R, Davey, E J, Shillitoe

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(1)

Human oral cancer cells may have any of several genetic changes, but the role of the bcl-2 oncogene is relatively unexplored. To find out if this gene plays a significant role and whether it could act as a target for gene therapy of oral cancer, we h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::108b3ae43b4ffc6292baa9d42792a16a
https://pubmed.ncbi.nlm.nih.gov/10656452

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Value of immunophenotype in intensively treated adult acute lymphoblastic leukemia: cancer and leukemia Group B study 8364

Autor: M S, Czuczman, R K, Dodge, C C, Stewart, S R, Frankel, F R, Davey, B L, Powell, T P, Szatrowski, C A, Schiffer, R A, Larson, C D, Bloomfield

Publikováno v: Blood. 93(11)

The prognostic value of immunophenotype in adult acute lymphoblastic leukemia (ALL) has varied based on the methods used, surface markers studied, and therapy administered. From April 1991 to September 1996, samples of leukemic marrow or blood from 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b627675899a05158556b45ab1d077f3d
https://pubmed.ncbi.nlm.nih.gov/10339502

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Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype

Autor: C D, Bloomfield, D, Lawrence, J C, Byrd, A, Carroll, M J, Pettenati, R, Tantravahi, S R, Patil, F R, Davey, D T, Berg, C A, Schiffer, D C, Arthur, R J, Mayer

Publikováno v: Cancer research. 58(18)

Advances in the treatment of acute myeloid leukemia (AML) have occurred with the introduction of new therapies including high-dose cytarabine and the identification of powerful prognostic factors such as cytogenetics that predict for long-term outcom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3710d7946bac0c22b447faad905ea6a3
https://pubmed.ncbi.nlm.nih.gov/9751631

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A randomized controlled trial of filgrastim during remission induction and consolidation chemotherapy for adults with acute lymphoblastic leukemia: CALGB study 9111

Autor: R A, Larson, R K, Dodge, C A, Linker, R M, Stone, B L, Powell, E J, Lee, P, Schulman, F R, Davey, S R, Frankel, C D, Bloomfield, S L, George, C A, Schiffer

Publikováno v: Blood. 92(5)

Recombinant human granulocyte colony-stimulating factor (G-CSF; filgrastim) shortens the time to neutrophil recovery after intensive chemotherapy, but its role in the treatment of adults with acute lymphoblastic leukemia (ALL) is uncertain. We random

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7ec21f322c842001cf34aa71ad8ebd9
https://pubmed.ncbi.nlm.nih.gov/9716583

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Double esterase staining and other neutrophilic granule abnormalities in 237 patients with the myelodysplastic syndrome studied by the cancer and leukemia group B

Autor: F R Davey, C A Schiffer, L R Silverman, Arthur K. Sullivan, D A Nelson, J MacCallum, B Peterson, C D Bloomfield, M T Elghetany, J F Varney

Publikováno v: Acta haematologica. 100(1)

We investigated double (specific and nonspecific) esterase (DE) staining in marrow cells of 237 patients with the myelodysplastic syndromes (MDS). Additional abnormalities of neutrophilic granules were examined cytochemically and immunocytochemically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfc3247172863cee71e7d0e5ed713a2
https://pubmed.ncbi.nlm.nih.gov/9691140

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Acute myeloid leukemia with 11q23 translocations: myelomonocytic immunophenotype by multiparameter flow cytometry

Autor: Celia A. Schiffer, Krzysztof Mrózek, Maria R. Baer, Clara D. Bloomfield, Carleton C. Stewart, Matthew P. Strout, David Lawrence, F R Davey, Diane C. Arthur

Publikováno v: Leukemia. 12(3)

11q23 translocations (t(11q23)) are recurring cytogenetic abnormalities in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia, involving the same gene, ALL1 (or MLL). Mixed lineage antigen expression has been reported in these leukemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd4fb9a0ec4c68456a3e9bc5f8eee71
https://pubmed.ncbi.nlm.nih.gov/9529125

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Expression of the neural cell adhesion molecule CD56 is associated with short remission duration and survival in acute myeloid leukemia with t(8;21)(q22;q22)

Autor: M R, Baer, C C, Stewart, D, Lawrence, D C, Arthur, J C, Byrd, F R, Davey, C A, Schiffer, C D, Bloomfield

Publikováno v: Blood. 90(4)

Although acute myeloid leukemia (AML) with t(8;21) (q22;q22) is associated with a high complete remission (CR) rate and prolonged disease-free survival, treatment outcome is not universally favorable. Identifying factors that predict for treatment ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8c7d6e24f3ad4a5e5ce32af93298a2f
https://pubmed.ncbi.nlm.nih.gov/9269784

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Secondary cytogenetic changes in acute promyelocytic leukemia--prognostic importance in patients treated with chemotherapy alone and association with the intron 3 breakpoint of the PML gene: a Cancer and Leukemia Group B study

Autor: S. Bigner, David Lawrence, Robert J. Mayer, R. Tantravahi, Charles A. Schiffer, A. J. Carroll, Kathleen W. Rao, Clara D. Bloomfield, F. R. Davey, D. C. Arthur, M. J. Pettenati, James L. Slack, Krzysztof Mrózek

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 15(5)

PURPOSE To examine, in newly diagnosed patients with acute promyelocytic leukemia (APL), the prognostic significance of secondary cytogenetic changes and the relationship between such changes and the two major promyelocytic leukemia-retinoic acid rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d48e246abd99ed9a8b75ea6c3879b9
https://pubmed.ncbi.nlm.nih.gov/9164186

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A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811

Autor: R A, Larson, R K, Dodge, C P, Burns, E J, Lee, R M, Stone, P, Schulman, D, Duggan, F R, Davey, R E, Sobol, S R, Frankel

Publikováno v: Blood. 85(8)

The goal of this phase II multicenter clinical trial was to evaluate a new intensive chemotherapy program for adults with untreated acute lymphoblastic leukemia (ALL) and to examine prospectively the impact of clinical and biologic characteristics on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09fe12b4516687d0274648446154e971
https://pubmed.ncbi.nlm.nih.gov/7718875

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Detection of MLL gene rearrangements in adult acute lymphoblastic leukemia. A Cancer and Leukemia Group B study

Autor: W, Stock, M J, Thirman, R K, Dodge, J D, Rowley, M O, Diaz, D, Wurster-Hill, R E, Sobol, F R, Davey, R A, Larson, C A, Westbrook

Publikováno v: Leukemia. 8(11)

Specific structural rearrangements involving chromosome band 11q23 occur in a variety of hematologic malignancies, including an estimated 2-7% of patients with acute lymphoblastic leukemia (ALL). Translocations involving chromosome band 11q23 have be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62a85e2ea43671e37053d17b014d32e9
https://pubmed.ncbi.nlm.nih.gov/7967737

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