Výsledky vyhledávání - "F. Pontillon"

Myeloma light chains are ligands for cubilin (gp280)

Autor: F. O. Goda, Timothy G. Hammond, Pierre J. Verroust, J. H. Kaysen, F. Pontillon, Eric E. Simon, Wendy C. Campbell, Joanne Bruno, Gabriel L. Navar, Vecihi Batuman, Michelle Lyles

Publikováno v: American Journal of Physiology-Renal Physiology. 275:F246-F254

Although myeloma light chains are known to undergo receptor-mediated endocytosis in the kidney, the molecular identity of the receptor has not been characterized. We examined the interaction between cubilin (gp280) and four species of light chains is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3557ee9c13eed3bf0dee4a3e077a58b
https://doi.org/10.1152/ajprenal.1998.275.2.f246

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Gentamicin inhibits rat renal cortical homotypic endosomal fusion: role of megalin

Autor: F. Pontillon, R. R. Majewski, Gabriel L. Navar, P. J. Verroust, J. H. Kaysen, F. O. Goda, Timothy G. Hammond

Publikováno v: American Journal of Physiology-Renal Physiology. 272:F117-F123

Megalin, a giant glycoprotein receptor heavily concentrated in the early endosomal pathway of renal proximal tubular cells, binds gentamicin with high affinity and delivers the drug to lysosomes. Utilizing an in vitro reconstitution assay we tested w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af87510afb4eedf6c9a72f2636e8a663
https://doi.org/10.1152/ajprenal.1997.272.1.f117

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Membrane potential mediates H(+)-ATPase dependence of 'degradative pathway' endosomal fusion

Autor: Pierre J. Verroust, W. C. Campbell, F. Pontillon, Gabriel L. Navar, Timothy G. Hammond, Daniel L. Galvan, J. H. Kaysen, Thomas J. Goodwin, F. O. Goda, R. R. Majewski, S. W. Paddock

Publikováno v: The Journal of membrane biology. 162(2)

In some epithelial cell lines, the uptake and degradation of proteins is so pronounced as to be regarded as a specialized function known as "degradative endocytosis." The endosomal pathways of the renal proximal tubule and the visceral yolk sac share

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f96b432d15f39187dfe870a8668d079
https://pubmed.ncbi.nlm.nih.gov/9538509

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The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins

Autor: Timothy G. Hammond, Mette Kristiansen, J. H. Kaysen, F. O. Goda, Pierre J. Verroust, Erik Ilsø Christensen, Søren K. Moestrup, Didier Brault, F. Pontillon, Hanne H. Rasmussen, Renata Kozyraki

Publikováno v: Moestrup, S K, Kozyraki, R, Madsen, M, Kaysen, J H, Rasmussen, H H, Brault, D, Pontillon, F, Goda, F O, Christensen, E I, Hammond, T G & Verroust, P J 1998, ' The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins ', The Journal of biological chemistry, vol. 273, no. 9, pp. 5235-42 . https://doi.org/10.1074/jbc.273.9.5235

The present report shows the molecular characterization of the rat 460-kDa epithelial glycoprotein that functions as the receptor facilitating uptake of intrinsic factor-vitamin B12 complexes in the intestine and kidney. The same receptor represents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3eafce6a4c55b4f5493a398212e36d
https://pubmed.ncbi.nlm.nih.gov/9478979

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Angiotensin II (AII)-related idiotypic network. I. Common occurrence of AII internal image on rabbit anti-idiotypic antibodies

Autor: F Pontillon, P Moullier, P M Ronco, P J Verroust

Publikováno v: The Journal of Immunology. 140:3052-3058

Internal images of foreign Ag have been demonstrated in a variety of systems as anticipated by the idiotypic network theory formulated by Jerne. However, they seem to be of rare occurrence. In order to estimate the actual frequency of antibodies bear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3173a766e3e6ee88a086f9283f3a2a9
https://doi.org/10.4049/jimmunol.140.9.3052

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Characterization of monoclonal antibodies specific for human Tamm–Horsfall protein

Autor: Gabriel Richet, Phillippe Moullier, Pierre J. Verroust, Pierre Ronco, M. Brunisholz, F. Pontillon, M. Geniteau–Legendre

Publikováno v: Kidney International. 29(5):971-976

Production of monoclonal antibodies specific for human Tamm–Horsfall protein. Fifteen monoclonal antibodies have been produced to human Tamm–Horsfall protein (THP), identifying at least seven distinct epitopes. The antibodies have been used to is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4278e12914a9c9c523eb21b622ddb1c5

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Angiotensin II (AII)-related idiotypic network. II. Heterogeneity and fine specificity of AII internal images analyzed with monoclonal antibodies

Autor: M Budisavljevic, M Geniteau-Legendre, B Baudouin, F Pontillon, P J Verroust, P M Ronco

Publikováno v: The Journal of Immunology. 140:3059-3065

Although the structural basis of internal images borne by beta type monoclonal anti-idiotypic antibody (Ab2) begins to be elucidated, there is little information on the repertoire of epitopes which make up the internal images expressed by polyclonal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d4bdd727383779306a671c810b7d462
https://doi.org/10.4049/jimmunol.140.9.3059

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Progressive glomerulonephritis in mice treated with interferon preparations at birth

Autor: Liliane Morel-Maroger, Chantel Maury, F. Pontillon, Ion Gresser, Michael G. Tovey

Publikováno v: Nature. 263:420-422

IN addition to the well known antiviral action1 interferon preparations exert various biological effects on cells (for references see refs 2 and 3). While investigating the effect of interferon on the growth and development of newborn mice, we found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfb70fae87b87e987815a15d1c3e638
https://doi.org/10.1038/263420a0

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A solid-phase radioimmunoassay for anti-SNP antibodies

Autor: F. Pontillon, C. Adam, P. Robitaille, P. Verroust

Publikováno v: Journal of immunological methods. 27(2)

A highly sensitive and discriminatory solid-phase radioimmunoassay has been developed to detect anti-SNP antibodies in sera. Polystyrene tubes are coated with SNP and incubated with the test sera. The fixed antibodies are detected by a double layer t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbb62e56929871da40bf4fb9b6ad1e4
https://pubmed.ncbi.nlm.nih.gov/458169

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