Zobrazeno 1 - 10
of 22
pro vyhledávání: '"F. Overzet"'
Autor:
J. L. de Boer, H.O. Van Oven, F. Jellinek, H.J. de Liefde Meijer, H. R. van der Wal, F. Overzet
Publikováno v:
Journal of Organometallic Chemistry, 92(3), 329-340. Elsevier Science
The syntheses and the results of mass spectrometry and infrared spectroscopy are reported of cyclooctatetraenetitanium chloride and its adducts with the donor molecules THF, diethylamine, pyrrolidine and pyridine. Single-crystal X-ray diffraction sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e451abfb56805d2b94c0cf39e819d98b
https://doi.org/10.1016/s0022-328x(00)85684-3
https://doi.org/10.1016/s0022-328x(00)85684-3
Publikováno v:
Journal of High Resolution Chromatography. 4:448-453
This paper describes the screening for metabolites of butoprozine, a new anti-anginal drug, in dog bile by means of reverse-phase HPLC. Although it does involve a simple clean-up step to remove a substantial amount of endogenous bile compounds, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31d1cee2d41a6783555d077fa52e1da4
https://doi.org/10.1002/jhrc.1240040905
https://doi.org/10.1002/jhrc.1240040905
Autor:
F. Overzet
Publikováno v:
Journal of high resolution chromatography & chromatography communications, 5(11), 604-615
This article presents a detailed account of the isolation of drug metabolites from bile by reverse-phase HPLC. The systematic approach is illustrated for the metabolism of butoprozine, a new antianginal drug, in the dog. Separation utilizes isocratic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9094084b3df30798b854ad6543f7d4b
https://doi.org/10.1002/jhrc.1240051104
https://doi.org/10.1002/jhrc.1240051104
Autor:
R. A. De Zeeuw, F. Overzet
Publikováno v:
Xenobiotica. 15:1-10
1. All detectable biliary butoprozine metabolites can be separated with a specially developed analytical approach based on gradient-elution reversed-phase h.p.l.c. without extraction steps.2. The high reproducibility of the h.p.l.c. systems allows pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30275a82c27fac3d514b431ed2578af7
https://doi.org/10.3109/00498258509045329
https://doi.org/10.3109/00498258509045329
Publikováno v:
Journal of High Resolution Chromatography. 5:192-198
This article describes the use of a multichannel UV-VIS detector coupled on-line to an HPLC instrument. Simultaneous measurements of the absorption of a compound over a full range of wavelengths (200–800 nm) makes this almost universal detector a u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92399c3109b9063fa5917a88c4bba780
https://doi.org/10.1002/jhrc.1240050405
https://doi.org/10.1002/jhrc.1240050405
Autor:
H. R. VAN DER WAL, F. OVERZET, H. O. VAN OVEN, J. L. DE BOER, H. J. DE LIEFDE MEIJER, F. JELLINEK
Publikováno v:
Chemischer Informationsdienst. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::442ad9afdaaf7472bf21fdda4479c533
https://doi.org/10.1002/chin.197539299
https://doi.org/10.1002/chin.197539299
Autor:
R.A. de Zeeuw, F. Overzet
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 2(1)
A systematic approach to the recognition, isolation and identification of metabolites of butoprozine in human bile is described as an example of the general approach in this area. Human profiles are compared with those obtained after administration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2c468c15dfa80fdf5a0ef66039b728
https://pubmed.ncbi.nlm.nih.gov/16867761
https://pubmed.ncbi.nlm.nih.gov/16867761
Publikováno v:
Drug Metabolite Isolation and Determination ISBN: 9781468444865
In establishing drug metabolite profiles, preferably with radio-labelled parent drug, HPLC is an effective approach, aided by a solvent gradient where the compounds are of widely different character [1]. Detection results can be misleading if obtaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3888b100c9741638a7091ee6e054e9b7
https://doi.org/10.1007/978-1-4684-4484-1_11
https://doi.org/10.1007/978-1-4684-4484-1_11
Publikováno v:
Scopus-Elsevier
Journal of Chromatography A, 267(2), 329-345. ELSEVIER SCIENCE BV
Journal of Chromatography A, 267(2), 329-345. ELSEVIER SCIENCE BV
The direct coupling of a multi-channel diode array UV-visible spectrophotometer to a powerful reversed-phase HPLC separation system is considered, especially for use in qualitative analysis, e.g., screening/identification of drugs and drug metabolite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4a53d25154926582700a1a74b6bcd1
https://pubmed.ncbi.nlm.nih.gov/6630371
https://pubmed.ncbi.nlm.nih.gov/6630371
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