Zobrazeno 1 - 10
of 133
pro vyhledávání: '"F. Orth"'
Autor:
Kai Voeltzke, Katerina Scharov, Cornelius Maximilian Funk, Alisa Kahler, Daniel Picard, Laura Hauffe, Martin F. Orth, Marc Remke, Irene Esposito, Thomas Kirchner, Alexander Schramm, Barak Rotblat, Thomas G. P. Grünewald, Guido Reifenberger, Gabriel Leprivier
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Neuroblastoma (NB) accounts for 15% of cancer-related deaths in childhood despite considerable therapeutic improvements. While several risk factors, including MYCN amplification and alterations in RAS and p53 pathway genes, have been defined
Externí odkaz:
https://doaj.org/article/244756c255e34dd1bac4f9113fd7ebc5
Autor:
Florencia Cidre-Aranaz, Jing Li, Tilman L. B. Hölting, Martin F. Orth, Roland Imle, Stefanie Kutschmann, Giulia Ammirati, Katharina Ceranski, Martha Julia Carreño-Gonzalez, Merve Kasan, Aruna Marchetto, Cornelius M. Funk, Felix Bestvater, Simone Bersini, Chiara Arrigoni, Matteo Moretti, Uwe Thiel, Daniel Baumhoer, Felix Sahm, Stefan M. Pfister, Wolfgang Hartmann, Uta Dirksen, Laura Romero-Pérez, Ana Banito, Shunya Ohmura, Julian Musa, Thomas Kirchner, Maximilian M. L. Knott, Thomas G. P. Grünewald
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-7 (2022)
Externí odkaz:
https://doaj.org/article/1cce4678ba46427fbe83c1b716396bda
Autor:
Jing Li, Shunya Ohmura, Aruna Marchetto, Martin F. Orth, Roland Imle, Marlene Dallmayer, Julian Musa, Maximilian M. L. Knott, Tilman L. B. Hölting, Stefanie Stein, Cornelius M. Funk, Ana Sastre, Javier Alonso, Felix Bestvater, Merve Kasan, Laura Romero-Pérez, Wolfgang Hartmann, Andreas Ranft, Ana Banito, Uta Dirksen, Thomas Kirchner, Florencia Cidre-Aranaz, Thomas G. P. Grünewald
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
In this study, the authors show that that oncogenic hijacking of PRC1 sensitizes genomically stable Ewing sarcoma cells for PLK1 inhibition alone or in synergy with a microtubule-destabilizing drug via induction of cytokinesis defects, rendering PRC1
Externí odkaz:
https://doaj.org/article/620b86da89cd44d2bbf793a753d0ae4f
Autor:
Shunya Ohmura, Aruna Marchetto, Martin F. Orth, Jing Li, Susanne Jabar, Andreas Ranft, Endrit Vinca, Katharina Ceranski, Martha J. Carreño-Gonzalez, Laura Romero-Pérez, Fabienne S. Wehweck, Julian Musa, Felix Bestvater, Maximilian M. L. Knott, Tilman L. B. Hölting, Wolfgang Hartmann, Uta Dirksen, Thomas Kirchner, Florencia Cidre-Aranaz, Thomas G. P. Grünewald
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-7 (2021)
Externí odkaz:
https://doaj.org/article/e5b2afe00395468698e4d825cb3744ab
Autor:
Aruna Marchetto, Shunya Ohmura, Martin F. Orth, Maximilian M. L. Knott, Maria V. Colombo, Chiara Arrigoni, Victor Bardinet, David Saucier, Fabienne S. Wehweck, Jing Li, Stefanie Stein, Julia S. Gerke, Michaela C. Baldauf, Julian Musa, Marlene Dallmayer, Laura Romero-Pérez, Tilman L. B. Hölting, James F. Amatruda, Andrea Cossarizza, Anton G. Henssen, Thomas Kirchner, Matteo Moretti, Florencia Cidre-Aranaz, Giuseppina Sannino, Thomas G. P. Grünewald
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Ewing sarcoma is characterized by the fusion of EWSR1 and FLI1. Here, the authors show that EWSR1-FLI1 increases the activity of the developmental transcription factor SOX6, which promotes tumor growth but also increases sensitivity to oxidative stre
Externí odkaz:
https://doaj.org/article/6dc51a99a4e44ac186061ab97fa34c62
Autor:
Konrad Steinestel, Marcel Trautmann, Esther‐Pia Jansen, Uta Dirksen, Jan Rehkämper, Jan‐Henrik Mikesch, Julia S. Gerke, Martin F. Orth, Giuseppina Sannino, Maria‐Francisca Arteaga, Claudia Rossig, Eva Wardelmann, Thomas G. P. Grünewald, Wolfgang Hartmann
Publikováno v:
Molecular Oncology, Vol 14, Iss 2, Pp 248-260 (2020)
Oncogenesis of Ewing sarcoma (EwS), the second most common malignant bone tumor of childhood and adolescence, is dependent on the expression of chimeric EWSR1‐ETS fusion oncogenes, most often EWSR1‐FLI1 (E/F). E/F expression leads to dysregulatio
Externí odkaz:
https://doaj.org/article/3db38cc851124a8999775124ae77ddbe
Autor:
Julian Musa, Florencia Cidre-Aranaz, Marie-Ming Aynaud, Martin F. Orth, Maximilian M. L. Knott, Olivier Mirabeau, Gal Mazor, Mor Varon, Tilman L. B. Hölting, Sandrine Grossetête, Moritz Gartlgruber, Didier Surdez, Julia S. Gerke, Shunya Ohmura, Aruna Marchetto, Marlene Dallmayer, Michaela C. Baldauf, Stefanie Stein, Giuseppina Sannino, Jing Li, Laura Romero-Pérez, Frank Westermann, Wolfgang Hartmann, Uta Dirksen, Melissa Gymrek, Nathaniel D. Anderson, Adam Shlien, Barak Rotblat, Thomas Kirchner, Olivier Delattre, Thomas G. P. Grünewald
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Interactions between germline variants and somatic mutations is a relatively unexplored topic in cancer. Here, in Ewing sarcoma, the authors show that binding of the oncogenic EWSR1-FLI1 fusion transcription factor to a polymorphic enhancer-like DNA
Externí odkaz:
https://doaj.org/article/b15283577e6941feafb9a8d8c4019ddd
Autor:
Giuseppina Sannino, Aruna Marchetto, Andreas Ranft, Susanne Jabar, Constanze Zacherl, Rebeca Alba-Rubio, Stefanie Stein, Fabienne S. Wehweck, Merve M. Kiran, Tilman L.B. Hölting, Julian Musa, Laura Romero-Pérez, Florencia Cidre-Aranaz, Maximilian M.L. Knott, Jing Li, Heribert Jürgens, Ana Sastre, Javier Alonso, Willian Da Silveira, Gary Hardiman, Julia S. Gerke, Martin F. Orth, Wolfgang Hartmann, Thomas Kirchner, Shunya Ohmura, Uta Dirksen, Thomas G.P. Grünewald
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 156-162 (2019)
Background: Up to 30–40% of Ewing sarcoma (EwS) patients with non-metastatic disease develop local or metastatic relapse within a time span of 2–10 years. This is in part caused by the absence of prognostic biomarkers that can identify high-risk
Externí odkaz:
https://doaj.org/article/519688e9d40c4215ae075d85d43e55cd
Autor:
Ilaria Elia, Dorien Broekaert, Stefan Christen, Ruben Boon, Enrico Radaelli, Martin F. Orth, Catherine Verfaillie, Thomas G. P. Grünewald, Sarah-Maria Fendt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Metastasizing cancer cells rewire their metabolism to support their malignant phenotypes. Here, the authors show that the acquisition of a metastatic phenotype in breast cancer cell lines results in increased proline catabolism and that inhibition of
Externí odkaz:
https://doaj.org/article/69af72ab34f4448d9adc1e35ac453ca9
Autor:
Aruna Marchetto, Shunya Ohmura, Martin F. Orth, Maximilian M. L. Knott, Maria V. Colombo, Chiara Arrigoni, Victor Bardinet, David Saucier, Fabienne S. Wehweck, Jing Li, Stefanie Stein, Julia S. Gerke, Michaela C. Baldauf, Julian Musa, Marlene Dallmayer, Laura Romero-Pérez, Tilman L. B. Hölting, James F. Amatruda, Andrea Cossarizza, Anton G. Henssen, Thomas Kirchner, Matteo Moretti, Florencia Cidre-Aranaz, Giuseppina Sannino, Thomas G. P. Grünewald
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20017-2
Externí odkaz:
https://doaj.org/article/695c85c77f7b474cb476de9a68f5c58f