Schistosoma mansoni Coinfection Attenuates Murine Toxoplasma gondii-Induced Crohn's-Like Ileitis by Preserving the Epithelial Barrier and Downregulating the Inflammatory Response

Autor: Beatriz Pêgo, Cesonia A. Martinusso, Claudio Bernardazzi, Beatriz Elias Ribeiro, Aline Fernandes de Araujo Cunha, Jacilene de Souza Mesquita, Hayandra F. Nanini, Marcelo Pelajo Machado, Morgana T. L. Castelo-Branco, Marta Guimarães Cavalcanti, Heitor S. P. de Souza

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Background and aims: Mice orally infected with T. gondii develop Crohn's disease (CD)-like enteritis associated with severe mucosal damage and a systemic inflammatory response, resulting in high morbidity and mortality. Previously, helminthic infecti

Externí odkaz: https://doaj.org/article/ffc41fbb58ea421da0810a8f06f445c9

Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease

Autor: Elias Anaissie, Siane Lopes Bittencourt Rosas, Cynthia Machado Cascabulho, Hayandra F. Nanini, Katia Farias E Silva, Patricia T. Santana, Marcio Nucci, Antonio José V. Carneiro, Heitor Siffert Pereira de Souza

Publikováno v: World Journal of Gastroenterology

BACKGROUND 1,3-beta-D-glucan (BG) is a ubiquitous cell wall component of gut micro-organisms. We hypothesized that the serum levels of BG could reflect active intestinal inflammation in patients with inflammatory bowel disease. AIM To determine wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0263ff374822b817179752f98cfe8e37
https://doi.org/10.3748/wjg.v27.i9.866

Bioactive Compounds from Pale Ale Beer Powder Attenuate Experimental Colitis in BALB/c Mice

Autor: Paola D. D. S. Maia, Diego dos Santos Baião, Hayandra F. Nanini, Victor Paulo F. da Silva, Lissa Bantim Frambach, Iuri Matheus Cabral, Beatriz Pêgo, Beatriz E. Ribeiro, Mauro Sérgio Gonçalves Pavão, Vania M. F. Paschoalin, Heitor S. P. de Souza, Anna Paola T. R. Pierucci

Publikováno v: Molecules; Volume 27; Issue 4; Pages: 1194

Phenolic compounds (PCs) present in foods are associated with a decreased risk of developing inflammatory diseases. The aim of this study was to extract and characterize PCs from craft beer powder and evaluate their potential benefits in an experimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219c7bfe83060708dc7635dac8d9c383
https://doi.org/10.3390/molecules27041194

P2X7 receptor promotes intestinal inflammation in chemically induced colitis and triggers death of mucosal regulatory T cells

Autor: Vanessa Ribeiro Figliuolo, Heitor Siffert Pereira de Souza, Pierre Bobé, Claudio Bernardazzi, Hanaa Safya, Cláudia Mara Lara Melo Coutinho, Hayandra F. Nanini, Jean Kanellopoulos, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva, Alessandra Alves Abalo

Publikováno v: BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2017, ⟨10.1016/j.bbadis.2017.03.004⟩
BBA-Biochimica et Biophysica Acta, 2017, ⟨10.1016/j.bbadis.2017.03.004⟩

P2X7 receptor activation contributes to inflammation development in different pathologies. We previously reported that the P2X7 receptor is over-expressed in the gut mucosa of patients with inflammatory bowel disease, and that P2X7 inhibition protect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0daf80a2ac1a72ac726689516b613e
https://doi.org/10.1016/j.bbadis.2017.03.004

27 THE P2X7 RECEPTOR MODULATES INFLAMMATION AND COLLAGEN DEPOSITION IN EXPERIMENTAL CHRONIC COLITIS AND COLOCALIZES WITH HUMAN IBD COLONIC MYOFIBROBLASTS

Autor: João Carlos Machado, Beatriz Elias Ribeiro, Heitor S. de Souza, Robson Coutinho-Silva, Patricia T. Santana, Hayandra F. Nanini, Cynthia Machado Cascabulho, Rodrigo P. de Oliveira, Morgana T. Castelo-Branco

Publikováno v: Gastroenterology. 160:S-7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2eb150784e9495b7abf4ae6a1107d8a
https://doi.org/10.1016/s0016-5085(21)00764-2