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Increases in fire risk due to warmer summer temperatures and wildland urban interface changes do not necessarily lead to more fires

Autor: D.M. Fox, N. Martin, P. Carrega, J. Andrieu, C. Adnès, K. Emsellem, O. Ganga, F. Moebius, N. Tortorollo, E.A. Fox

Publikováno v: Applied Geography
Applied Geography, Elsevier, 2014, pp.12. ⟨10.1016/j.apgeog.2014.10.001⟩
Applied Geography, 2014, pp.12. ⟨10.1016/j.apgeog.2014.10.001⟩

International audience; Forest fire frequency in Mediterranean countries is expected to increase with land cover and climate changes as temperatures rise and rainfall patterns are altered. Although the cause of many Mediterra-nean fires remains poorl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7ef092d280211931e2838ea400c4bc
https://hal.archives-ouvertes.fr/hal-01133187

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Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform

Autor: Craig Montell, Fabian F. Moebius, Donald L. Gill, X.Z. Shawn Xu

Publikováno v: Proceedings of the National Academy of Sciences. 98:10692-10697

The TRP (transient receptor potential) superfamily includes a group of subfamilies of channel-like proteins mediating a multitude of physiological signaling processes. The TRP-melastatin (TRPM) subfamily includes the putative tumor suppressor melasta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbd86ca6d34f4472ce90c7c4c4b1b9c
https://doi.org/10.1073/pnas.191360198

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Genetic Defects in Postsqualene Cholesterol Biosynthesis

Autor: Barbara U. Fitzky, Fabian F. Moebius, Hartmut Glossmann

Publikováno v: Trends in Endocrinology & Metabolism. 11:106-114

In humans and mice, four different genetic defects in the nine biosynthetic steps from lanosterol to cholesterol have been identified. They impair the activity of a putative C3-sterol dehydrogenase (Nshdl, X-linked dominant bare patches/striated muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2a759470d54f57b2db33d101feb866
https://doi.org/10.1016/s1043-2760(00)00235-6

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Mutational Spectrum in the Δ7-Sterol Reductase Gene and Genotype-Phenotype Correlation in 84 Patients with Smith-Lemli-Opitz Syndrome

Autor: Hartmut Glossmann, Georg F. Hoffmann, Peter Clayton, Richard I. Kelley, F. F. Moebius, Barbara U. Fitzky, Udo Seedorf, G. Gillessen-Kaesbach, Martina Witsch-Baumgartner, M. Ogorelkova, H. G. Kraft, Gerd Utermann

Publikováno v: The American Journal of Human Genetics. 66:402-412

SummarySmith-Lemli-Opitz syndrome (SLOS), an autosomal recessive malformation syndrome, ranges in clinical severity from mild dysmorphism and moderate mental retardation to severe congenital malformation and intrauterine lethality. Mutations in the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a9159f9ce24bbd3389725e5a95313b
https://doi.org/10.1086/302760

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Mutations in the gene encoding 3β- hydroxysteroid-Δ8,Δ7- isomerase cause X-linked dominant Conradi-Hünermann syndrome

Autor: Cassandra Obie, Hartmut Glossmann, William R. Wilcox, David Valle, Nancy Braverman, David L. Rimoin, Richard I. Kelley, Lisa E. Kratz, Fabian F. Moebius, Moyra Smith, Ann B. Moser, Paul Lin

Publikováno v: Nature Genetics. 22:291-294

X-linked dominant Conradi-Hünermann syndrome (CDPX2; MIM 302960) is one of a group of disorders with aberrant punctate calcification in cartilage, or chondrodysplasia punctata (CDP). This is most prominent around the vertebral column, pelvis and lon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ebebfcd3ed73989b489d5d2144aea3
https://doi.org/10.1038/10357

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Histidine77, Glutamic Acid81, Glutamic Acid123, Threonine126, Asparagine194, and Tryptophan197 of the Human Emopamil Binding Protein Are Required for in Vivo Sterol Δ8−Δ7 Isomerization

Autor: Kristina E. M. Soellner, Günther K. Bonn, Birgit Fiechtner, Christian W. Huck, Fabian F. Moebius, Hartmut Glossmann

Publikováno v: Biochemistry. 38:1119-1127

The human emopamil binding protein (hEBP) exhibits sterol Delta8-Delta7 isomerase activity (EC 5.3.3.5) upon heterologous expression in a sterol Delta8-Delta7 isomerization-deficient erg2-3 yeast strain. Ala scanning mutagenesis was used to identify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5207fdde77e0ce3316c602d69ea35200
https://doi.org/10.1021/bi981804i

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Pharmacological Analysis of Sterol Δ8-Δ7 Isomerase Proteins with [3H]Ifenprodil

Autor: Katrin Bermoser, Young Ki Paik, Fabian F. Moebius, Hartmut Glossmann, Sang Yun Cho, Raphael J. Reiter

Publikováno v: Molecular Pharmacology. 54:591-598

Sterol Delta8-Delta7 isomerases (SIs) catalyze the shift of the double bond from C8-9 to C7-8 in the B-ring of sterols. Surprisingly, the isoenzymes in fungi (ERG2p) and vertebrates [emopamil binding protein (EBP)] are structurally completely unrelat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3625ba698442299529917629d9362524
https://doi.org/10.1124/mol.54.3.591

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