Zobrazeno 1 - 10
of 118
pro vyhledávání: '"F. Minto"'
Autor:
Charles F. Minto, Thomas W. Schnider
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 4, Pp 429-429 (2023)
Externí odkaz:
https://doaj.org/article/a6db29c609ff420d98565c1a97021407
Publikováno v:
Schnider, Thomas W; Minto, Charles F; Luginbühl, Martin; Egan, Talmage D (2022). The drug titration paradox: more drug does not correlate with more effect in individual clinical data. British journal of anaesthesia, 129(6), pp. 861-867. Oxford University Press 10.1016/j.bja.2022.05.036
BACKGROUND A fundamental concept in pharmacology is that increasing dose increases drug effect. This is the basis of anaesthetic titration: the dose is increased when increased drug effect is desired and decreased when reduced drug effect is desired.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196c95383ec17fc7a790dcc0533cbe73
Autor:
Thomas W. Schnider, Charles F. Minto
Publikováno v:
British journal of anaesthesia. 128(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87edc0cc7d3cb76352147d27d858c089
https://pubmed.ncbi.nlm.nih.gov/35397881
https://pubmed.ncbi.nlm.nih.gov/35397881
Publikováno v:
British journal of anaesthesia. 126(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a97dd686a480dc6b31c253e839ac7f
https://pubmed.ncbi.nlm.nih.gov/33934890
https://pubmed.ncbi.nlm.nih.gov/33934890
Publikováno v:
Clinical pharmacology and therapeutics. 110(2)
While analyzing clinical data where an anesthetic was titrated based on an objective measure of drug effect, we observed paradoxically that greater effect was associated with lesser dose. With this study we sought to find a mathematical explanation f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9cc540ee893fd1279269fee017a815
https://pubmed.ncbi.nlm.nih.gov/34038588
https://pubmed.ncbi.nlm.nih.gov/34038588
Publikováno v:
Anesthesia and analgesia. 132(3)
Background Internationally, propofol is commonly titrated by target-controlled infusion (TCI) to maintain a processed electroencephalographic (EEG) parameter (eg, bispectral index [BIS]) within a specified range. The overall variability in propofol t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c0addb52685d53de7297af41763eb0
https://pubmed.ncbi.nlm.nih.gov/32833715
https://pubmed.ncbi.nlm.nih.gov/32833715
Publikováno v:
Br J Anaesth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325525a410dde2a55cf0b61a0d62f9f4
https://pubmed.ncbi.nlm.nih.gov/31983410
https://pubmed.ncbi.nlm.nih.gov/31983410
Publikováno v:
Anesthesia & Analgesia. 122:79-85
Target-controlled infusion (TCI) technology has been available in most countries worldwide for clinical use in anesthesia for approximately 2 decades. This infusion mode uses pharmacokinetic models to calculate infusion rates necessary to reach and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad243677ca300e568a5a31e0711a381
https://doi.org/10.1213/ane.0000000000001005
https://doi.org/10.1213/ane.0000000000001005
Publikováno v:
Anesthesia & Analgesia. 131:e160-e160
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64b4c36d22f2557488b3d3e00f63e7a4
https://doi.org/10.1213/ane.0000000000004516
https://doi.org/10.1213/ane.0000000000004516
Autor:
Thomas W. Schnider, Charles F. Minto
Publikováno v:
Clinical Pharmacology & Therapeutics. 84:27-38
Pharmacokinetic (PK)/pharmacodynamic (PD) modeling has made an enormous contribution to intravenous anesthesia. PK/PD models have provided us with insight into the factors affecting the onset and offset of drug effect. For example, we are now able to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9e52106355387e584cc794f516716b
https://doi.org/10.1038/clpt.2008.100
https://doi.org/10.1038/clpt.2008.100