Zobrazeno 1 - 10
of 568
pro vyhledávání: '"F. McKay"'
Autor:
Robin John Shattock, Voahangy Andrianaivoarimanana, Paul F. McKay, Lovasoa Nomena Randriantseheno, Valarmathy Murugaiah, K. Samnuan, Paul Rogers, John S. Tregoning, Minoarisoa Rajerison, Kristoffer M. Moore, Thomas Robert Laws, E. Diane Williamson
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Mice were immunized with a combination of self-amplifying (sa) RNA constructs for the F1 and V antigens of Yersinia pestis at a dose level of 1 μg or 5 μg or with the respective protein sub-units as a reference vaccine. The immunization of outbred
Externí odkaz:
https://doaj.org/article/192ac3598338412086dec12fd8774ddc
Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines
Autor:
John S. Tregoning, David C. Stirling, Ziyin Wang, Katie E. Flight, Jonathan C. Brown, Anna K. Blakney, Paul F. McKay, Robert F. Cunliffe, Valarmathy Murugaiah, Christopher B. Fox, Mitchell Beattie, Ying K. Tam, Cecilia Johansson, Robin J. Shattock
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 29-42 (2023)
To be effective, RNA vaccines require both in situ translation and the induction of an immune response to recruit cells to the site of immunization. These factors can pull in opposite directions with the inflammation reducing expression of the vaccin
Externí odkaz:
https://doaj.org/article/0d6a34fafa0d4648b2111c1434bf06b4
Autor:
Sara Siris, Camilla A. Gladstone, Yanping Guo, Radhika Patel, Christopher L. Pinder, Robin J. Shattock, Paul F. McKay, Paul R. Langford, Fadil A. Bidmos
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Expression cloning of fully human monoclonal antibodies (hmAbs) is seeing powerful utility in the field of vaccinology, especially for elucidating vaccine-induced B-cell responses and novel vaccine candidate antigen discovery. Precision of the hmAb c
Externí odkaz:
https://doaj.org/article/fd11a446a0904d589cefc0ccb60c79c3
Autor:
Alessandra Gallinaro, Maria Franca Pirillo, Yoann Aldon, Serena Cecchetti, Zuleika Michelini, Antonella Tinari, Martina Borghi, Andrea Canitano, Paul F. McKay, Roberta Bona, Maria Fenicia Vescio, Felicia Grasso, Maria Blasi, Silvia Baroncelli, Gabriella Scarlatti, Celia LaBranche, David Montefiori, Mary E. Klotman, Rogier W. Sanders, Robin J. Shattock, Donatella Negri, Andrea Cara
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Integrase Defective Lentiviral Vectors (IDLVs) represent an attractive vaccine platform for delivering HIV-1 antigens, given their ability to induce specific and persistent immune responses in both mice and non-human primates (NHPs). Recent
Externí odkaz:
https://doaj.org/article/94f8ebf4de2b4e68add95d41c53acdd3
Autor:
Emma Lorenzen, Vanessa Contreras, Anja W. Olsen, Peter Andersen, Delphine Desjardins, Ida Rosenkrands, Helene Bæk Juel, Benoit Delache, Sebastien Langlois, Constance Delaugerre, Christophe Joubert, Nathalie Dereuddre-Bosquet, Cécile Bébéar, Bertille De Barbeyrac, Arabella Touati, Paul F. McKay, Robin J. Shattock, Roger Le Grand, Frank Follmann, Jes Dietrich
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
It is of international priority to develop a vaccine against sexually transmitted Chlamydia trachomatis infections to combat the continued global spread of the infection. The optimal immunization strategy still remains to be fully elucidated. The aim
Externí odkaz:
https://doaj.org/article/8eba49251cfe46ee8889846d67ba7fb9
Autor:
Kai Hu, Elena Palmieri, Karnyart Samnuan, Beatrice Ricchetti, Davide Oldrini, Paul F. McKay, Guanghui Wu, Leigh Thorne, Anthony R. Fooks, Lorraine M. McElhinney, Hooman Goharriz, Megan Golding, Robin J. Shattock, Francesca Micoli
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 11, Pp n/a-n/a (2022)
Abstract Vaccine platforms enable fast development, testing, and manufacture of more affordable vaccines. Here, we evaluated Generalized Modules for Membrane Antigens (GMMA), outer membrane vesicles (OMVs) generated by genetically modified Gram‐neg
Externí odkaz:
https://doaj.org/article/3e33e179ad1444a98db2c352043795a8
Autor:
Yoann Aldon, Paul F. McKay, Jorge Moreno Herrero, Annette B. Vogel, Réka Lévai, Pauline Maisonnasse, Nathalie Dereuddre-Bosquet, Heinrich Haas, Katalin Fábián, Roger Le Grand, Ugur Sahin, Robin J. Shattock
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 483-493 (2021)
Self-amplifying mRNA (saRNA) represents a promising platform for nucleic acid delivery of vaccine immunogens. Unlike plasmid DNA, saRNA does not require entry into the nucleus of target cells for expression, having the capacity to drive higher protei
Externí odkaz:
https://doaj.org/article/29be14ddbad34f018d2ece57d78aef2f
Autor:
Alexandra J. Spencer, Paul F. McKay, Sandra Belij-Rammerstorfer, Marta Ulaszewska, Cameron D. Bissett, Kai Hu, Karnyart Samnuan, Anna K. Blakney, Daniel Wright, Hannah R. Sharpe, Ciaran Gilbride, Adam Truby, Elizabeth R. Allen, Sarah C. Gilbert, Robin J. Shattock, Teresa Lambe
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Heterologous vaccination regimens for COVID-19 could be useful for example if there is a shortage of one vaccine type. Here, Spencer et al. show that heterologous vaccination with a self-amplifying RNA vaccine and an adenoviral vectored vaccine perfo
Externí odkaz:
https://doaj.org/article/b9635c93599e4d14abcf385c2298f08d
Autor:
Kai Hu, Paul F. McKay, Karnyart Samnuan, Adrian Najer, Anna K. Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M. Stevens, Robin J. Shattock
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 3, Pp n/a-n/a (2022)
Abstract A vaccine antigen, when launched as DNA or RNA, can be presented in various forms, including intracellular, secreted, membrane‐bound, or on extracellular vesicles (EVs). Whether an antigen in one or more of these forms is superior in immun
Externí odkaz:
https://doaj.org/article/c597076c7d2d40ebbde634f539a11f55
Autor:
Katrina M. Pollock, Hannah M. Cheeseman, Alexander J. Szubert, Vincenzo Libri, Marta Boffito, David Owen, Henry Bern, Jessica O'Hara, Leon R. McFarlane, Nana-Marie Lemm, Paul F. McKay, Tommy Rampling, Yee Ting N. Yim, Ana Milinkovic, Cherry Kingsley, Tom Cole, Susanne Fagerbrink, Marites Aban, Maniola Tanaka, Savviz Mehdipour, Alexander Robbins, William Budd, Saul N. Faust, Hana Hassanin, Catherine A. Cosgrove, Alan Winston, Sarah Fidler, David T. Dunn, Sheena McCormack, Robin J. Shattock
Publikováno v:
EClinicalMedicine, Vol 44, Iss , Pp 101262- (2022)
Summary: Background: Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is a novel technology formulated as a low dose vaccine against COVID-19. Methods: A phase I first-in-human dose-ranging trial of a saRNA COVID-19 vaccine candidate
Externí odkaz:
https://doaj.org/article/59824dcfc367459c9e970a7c3996b40c