Zobrazeno 1 - 10
of 667
pro vyhledávání: '"F. Malaisse-Lagae"'
Publikováno v:
Diabetologia. 35:505-509
Attenuation, suppression or even inversion of the normal preference of glucose-stimulated insulin release for the alpha-anomer of the hexose was recently proposed to represent a feature of Beta-cell glucotoxicity in Type 2 (non-insulin-dependent) dia
Autor:
Willy Malaisse, F. Malaisse-Lagae
Publikováno v:
Acta Diabetologica. 29:94-98
Islets from fed and 3-day-starved rats were incubated for 60 min in the presence of either 2.8 or 16.7 mM d-glucose, mixed with tracer amounts ofd-[5-3H]glucose,d-[3,4-14C]glucose,d-[6-14C]glucose andd-[2-14C]glucose. Starvation decreased the generat
Publikováno v:
Pharmacological Research. 33:273-275
The insulinotropic action of several new esters of succinic acid was assessed in isolated rat islets incubated in the presence of 7 mM D-glucose. An efficient secretory response was observed with the monobenzyl, monoisopropyl, monoallyl, monopropyl,
Autor:
W. J. Malaisse, F. Malaisse-Lagae
Publikováno v:
Acta Diabetologica. 33:298-300
The fate of 3H- and 14C-labelled A-4166 was examined in rat pancreatic islets. The net uptake of the meglitinide analogue by islets incubated for 60 min in the presence of 0.1 mM A-4166 and then submitted to repeated washes was close to 0.1 pmol/isle
Publikováno v:
Endocrine. 14(3)
Under conditions of sustained hyperglycemia, glycogen accumulates in pancreatic islets, but not so in acinar pancreatic cells. We investigated whether advantage could be taken of such a situation in the perspective of the noninvasive imaging of the e
Publikováno v:
International journal of molecular medicine. 7(3)
The uptake of [2-(14)C]alloxan by the pancreatic gland was investigated in control and streptozotocin-induced diabetic (STZ) rats, using both in vitro and in vivo techniques. Whether after 10 to 60 min incubation of pieces of pancreas in the presence
Publikováno v:
Cell biochemistry and function. 18(4)
In order to assess the respective contribution of the exocrine and endocrine moieties of the pancreas to the overall net uptake of selected monosaccharides by the pancreatic gland, the apparent distribution space of L-[1-14C]glucose, 3-O-[14C-methyl]
Publikováno v:
Endocrine. 13(1)
The fate of 6-deoxy-6-[125I]iodo-D-glucose (6-DIG), injected intravenously, was compared in control rats and animals that had received streptozotocin and were then treated with insulin or not. In the control rats, the measurement of plasma radioactiv
Publikováno v:
Pharmacological research. 40(6)
Both control and hereditarily diabetic (Goto-Kakizaki) rats were administered twice daily for 7 days with an oral solution of carboxymethylcellulose containing, when required, glibenclamide (1.0 microgram g-1 body wt.) or nateglinide (50.0 micrograms
Publikováno v:
Research communications in molecular pathology and pharmacology. 102(2)
The hypoglycemic sulfonylurea gliquidone, used at a 10 microM concentration, failed to affect the metabolism of D-glucose in rat pancreatic islets incubated in the presence of 5.6 mM, 8.3 mM or 16.7 mM D-glucose. However, at 2.8 mM D-glucose, gliquid