Zobrazeno 1 - 10
of 68
pro vyhledávání: '"F. M. Uckun"'
Publikováno v:
Synthetic Communications. 34:1489-1497
Polyhydroxylated stilbene analogs of piceatannol are shown to possess protein‐tyrosine kinase (PTK) inhibitory activity. We have developed a novel approach to introduce an amide moiety into the structure of piceatannol. The amido substituted stilbe
Autor:
F. M. Uckun, T. K. Venkatachalam
Publikováno v:
Synthetic Communications. 34:2451-2461
The regiospecific synthesis of 5‐halothiophenethylamines and halo‐substituted phenylethyl thioureas was accomplished with an overall yield of 45–60%. Condensation of t‐boc protected 2‐thiophenethylamine with N‐halo succinamide in dimethyl
Autor:
T. K. Venkatachalam, F. M. Uckun M.D.
Publikováno v:
Synthetic Communications. 34:2463-2472
Synthesis of β‐fluorophenethylamines was accomplished in three steps with an overall yield of 50%. Condensation of β‐fluorophenethylamine hydrochloride with thiocarbonylimidazole derivative derived from halopyridyl amines in dimethylformamide f
Publikováno v:
Synthetic Communications. 33:1185-1193
We developed a novel approach to introduce a carbohydrate moiety into the structure of thiourea compounds targeting the NNI binding pocket of the HIV-1 reverse transcriptase. The described method involves the synthesis of an amino-substituted carbohy
Publikováno v:
Leukemia & Lymphoma. 43:2355-2362
Janus tyrosine kinase 3 (JAK3) is one of several key regulatory enzymes in B-cell precursors which is highly conserved between multiple species. The gene for Jak3 has been mapped to human chromosome 19p12-13.1 and encompasses 23 exons. Constitutively
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 22:1771-1783
WHI-P154 [4-(3′-bromo-4′hydroxylphenyl)-amino-6,7 di-methoxyquinazoline] is a novel anti-tumor agent with unique cytotoxic activity against human glioblastoma cells (Clin. Cancer. Res. 4:1405-1414, 1998). Further development of WHI-P154 will requ
Autor:
Raymond J. Hutchinson, Gregory H. Reaman, Diane C. Arthur, Michael E. Trigg, Martha G. Sensel, James B. Nachman, F. M. Uckun, Peter G. Steinherz, Harland N. Sather, Paul S. Gaynon
Publikováno v:
Leukemia & Lymphoma. 27:445-457
Leukemic cells from most patients with B-lineage acute lymphoblastic leukemia (ALL) appear to originate from normal B-lymphocyte precursors. The earliest B-cell progenitors coexpress the antigens CD10, CD19, or CD34 on their cell surfaces. In a large
Autor:
Jonathan J. Shuster, F. M. Uckun, G Reaman, A Bleyer, Paul S. Gaynon, Lisa M. Chelstrom, Harland Sather, V Land, Roland Gunther, Michael E. Trigg
Publikováno v:
Blood. 85:873-878
Mice with severe combined immunodeficiency (SCID) provide a model system to examine the in vivo homing, engraftment, and growth patterns of normal and malignant human hematopoietic cells. The relation between leukemic cell growth in this model and th
Autor:
David H. Sachs, J. S. Arn, Craig Smith, D. E. Myers, Bruce R. Rosengard, T. Sablinski, F. M. Uckun
Publikováno v:
Journal of Immunotherapy. 16:105-114
Two monoclonal antibodies (mAb) with specificities for mature T-cell subsets in miniature swine have been characterized previously. Antibody 74-12-4 recognizes the porcine CD4 accessory molecule and 76-2-11 is specific for the CD8 molecule. We have n
Autor:
A. L. Burkhardt, F. M. Uckun, Joseph B. Bolen, Lisa Tuel-Ahlgren, Xiao Jun, B. Stealey, Lisa J. Jarvis, Ilker Dibirdik, Dorothea E. Myers
Publikováno v:
Journal of Biological Chemistry. 268:21172-21184
We present evidence that the CD19 receptor is functionally operative and transmits pleiotropic signals throughout the pro-B, pre-pre-B, pre-B, early B, and mature B cell stages of human B-cell ontogeny. The signaling ability of CD19 does not depend o