Zobrazeno 1 - 10
of 23
pro vyhledávání: '"F. M. Semchenko"'
Autor:
A. V. Sosnov, M. I. Vlasov, S. V. Sadovnikov, K. A. Rufanov, F. M. Semchenko, A. A. Sosnova, A. S. Radilov, E. I. Savelieva
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 4, Pp 108-124 (2019)
Application of luminescent reagents for detection of toxicants including warfare agents, pesticides and their degradation products and precursors has been systematically reviewed. Methods of organophosphorus toxicants and products of their destructio
Externí odkaz:
https://doaj.org/article/04c006d88dc34d92bd529654c7ef192c
Autor:
A. V. Sosnov, S. V. Sadovnikov, F. M. Semchenko, K. A. Rufanov, V. N. Tohmahchi, A. A. Sosnova, I. A. Tyurin
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 1, Pp 196-206 (2019)
The article describes some approaches to choice of the most potent non-narcotic analgesics among agents investigated in various R&D stages. Preparations non-narcotic analgesics for relief of severe and moderate pain are relatively new area of pharmac
Externí odkaz:
https://doaj.org/article/20e25fd954fa45c99e6f7c010cf1db9a
Autor:
A. V. Sosnov, F. M. Semchenko, V. N. Tohmahchi, A. A. Sosnova, M. I. Vlasov, A. S. Radilov, D. V. Krivorotov
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 3, Pp 114-128 (2019)
The global opioid crisis requires a paradigm shift in medical use of opioids, the development of methodology to reduce illicit drug use, and development of drug addiction treatment and antidotes. USA target program - HEAL Initiative is implemented un
Externí odkaz:
https://doaj.org/article/3a2b1611039340609ad5ad92ef553ca0
Autor:
A. V. Sosnov, S. S. Golubev, B. S. Punkevich, S. V. Sadovnikov, E. M. Zagrebin, I. S. Rodina, F. M. Semchenko, A. A. Sosnova
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 1, Pp 216-223 (2019)
The article describes acute problem - absence of reference standards (Federal Reference Standards) of controlled ingredients of some potent pharmaceuticals (especially narcotic and psychotropic substances) in Russia. Authors present an algorithm for
Externí odkaz:
https://doaj.org/article/a125d7c8d1b146279d01453be3167a3e
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 2, Pp 176-187 (2019)
Medicines based on opioid analgesics are the basic means of pharmacotherapy of severe pain at present. Approaches to increase efficacy and safety of complex opioid analgesia are described and classified based on analysis of medicinal and veterinary a
Externí odkaz:
https://doaj.org/article/a1a51f4d3b7c4081aefebb2131a13303
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 1, Pp 114-133 (2019)
Algorithm of selection of compounds and formulations for development of multi-purpose CNS targeted medicinal products for emergency field and civil therapy is justified on the example of potent analgesics. Key criteria and quantitative parameters for
Externí odkaz:
https://doaj.org/article/e85fd557148b465ab5611a08e11677f5
Autor:
A. V. Sosnov, S. S. Golubev, B. S. Punkevich, S. V. Sadovnikov, F. M. Semchenko, V. N. Tohmahchi, A. A. Sosnova
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 2, Pp 202-214 (2019)
According to comparative analysis of medical consumption of potent analgesics in economically developed countries was justified the need to increase production of active ingredients of potent analgesics in Russia by more than ten times. Also a list o
Externí odkaz:
https://doaj.org/article/e8aaa5c2d0034dc680099986fbdc426b
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 2, Pp 236-241 (2019)
The development of new antinociceptive agents and new approaches to pain relief based on potent non-narcotic analgesics is one of the most in demand and urgent directions of modern pharmacology. This work substantiates the choice of the clinically mo
Externí odkaz:
https://doaj.org/article/62addb1f82ba46c19305f98c809fa3cb
Autor:
M. S. Krymchak, V. V. Shalabai, A. V. Aksenov, V. F. Taranchenko, A. M. Antokhin, F. M. Semchenko, I. V. Rybal’chenko
Publikováno v:
Journal of Analytical Chemistry. 72:632-638
A procedure is developed for the identification and determination of tetrodotoxin in pharmaceuticals by liquid chromatography coupled with high resolution mass spectrometry (HPLC−HRMS). The components of a pharmaceutical sample were separated in th
Gas-chromatographic determination of trace amounts of tetrodotoxin in water, drugs, and blood plasma
Autor:
K. A. Rufanov, S. I. Dvoretskaya, O. T. Morozova, F. M. Semchenko, I. D. Derevyagina, V. I. Selivanova, V. B. Kondrat’ev, I. N. Stan’kov
Publikováno v:
Journal of Analytical Chemistry. 71:289-296
A method has been developed for the determination of tetrodotoxin in water, blood plasma, and drugs at a level of 0.05—1.0 µg/mL. The method is based on the hydrolytic decomposition of tetrodotoxin by a sodium hydroxide solution, extraction of 2-a