Výsledky vyhledávání - "F. M. Huennekens"

Autor: J. Fan, K. S. Vitols, L.E. Pope, F. M. Huennekens

Publikováno v: Journal of Nutritional Science and Vitaminology. 38:52-57

All eukaryotic cells and some prokaryotes that are unable to synthesize folic acid utilize membrane-associated transport systems for acquisition of the pre-formed vitamin or its coenzyme forms from external sources. These transport systems, in additi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5199ae3c8a7cd96ece4e1322c629515
https://doi.org/10.3177/jnsv.38.special_52

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Methotrexate-alpha-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate

Autor: K S, Vitols, B, Haag-Zeino, T, Baer, Y D, Montejano, F M, Huennekens

Publikováno v: Cancer research. 55(3)

Methotrexate-alpha-phenylalanine (MTX-Phe), a second-generation prodrug in the MTX alpha-peptide series designed for activation to MTX by carboxypeptidase-mAb conjugates, was synthesized by reaction of the p-nitrophenyl ester of 4-amino-4-deoxy-10-me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3855d07bbff94ed8ead88ea050b19c5b
https://pubmed.ncbi.nlm.nih.gov/7834611

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Novel substrate analogs delineate an endocytotic mechanism for uptake of folate via the high-affinity, glycosylphosphatidylinositol-linked transport protein in L1210 mouse leukemia cells

Autor: J, Fan, N, Kureshy, K S, Vitols, F M, Huennekens

Publikováno v: Oncology research. 7(10-11)

The mechanism of folate uptake, mediated by the high-affinity folate receptor linked via glycosylphosphatidylinositol to the plasma membrane of L1210 mouse leukemia cells, has been investigated with the use of two substrate analogs, a fluorescein der

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78f0617be010d83a3aba3176fa502c7f
https://pubmed.ncbi.nlm.nih.gov/8866663

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Biotin derivatives of methotrexate and folate. Synthesis and utilization for affinity purification of two membrane-associated folate transporters from L1210 cells

Autor: J, Fan, K S, Vitols, F M, Huennekens

Publikováno v: The Journal of biological chemistry. 266(23)

Biotin derivatives of methotrexate and folate (2-(biotinamido)ethyl-1,3'-dithiopropionyldiaminopentyl methotrexate and/or folate), in which carboxyl groups of the functional components are joined by a disulfide-containing spacer, have been synthesize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::061f7db9cd735824b43186b9b2c61ee3
https://pubmed.ncbi.nlm.nih.gov/1869524

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