Zobrazeno 1 - 10 of 52 pro vyhledávání: '"F. Lamie"'
1
Akademický článek
Novel N-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks
Autor: John N. Philoppes, Mohamed A. Abdelgawad, Mohammed A. S. Abourehab, Mohamed Sebak, Mostafa A. Darwish, Phoebe F. Lamie
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 246-266 (2023)
Three novel series of N-methylsulfonylindole derivatives 3a&b, 4a–e, and 5a–e were synthesised. Different biological activities of the synthesised compounds were studied. Antimicrobial activity showed that, compounds 4b, 4e and 5d had selective a
Externí odkaz: https://doaj.org/article/403177a113a1494f953f8b744f29c54a
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2
Akademický článek
Design and synthesis of new indole drug candidates to treat Alzheimer’s disease and targeting neuro-inflammation using a multi-target-directed ligand (MTDL) strategy
Autor: Phoebe F. Lamie, Maha M. Abdel-Fattah, John N. Philoppes
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2660-2678 (2022)
A novel series of indole-based compounds was designed, synthesised, and evaluated as anti-Alzheimer’s and anti-neuroinflammatory agents. The designed compounds were in vitro evaluated for their AChE and BuChE inhibitory activities. The obtained res
Externí odkaz: https://doaj.org/article/4fc73e36c7ed42c7938bd974b96b3387
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3
Akademický článek
2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors
Autor: Phoebe F. Lamie, John N. Philoppes
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 864-879 (2020)
A novel 2-thiopyrimidine/chalcone hybrid was designed, synthesised, and evaluated for their cytotoxic activities against three different cell lines, K-562, MCF-7, and HT-29. The most active cytotoxic derivatives were 9d, 9f, 9n, and 9p (IC50=0.77–1
Externí odkaz: https://doaj.org/article/5323007f7464438c93435026ff8bb74d
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5
Akademický článek
Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and docking study
Autor: Phoebe F. Lamie, John N. Philoppes, Amany A. Azouz, Nesreen M. Safwat
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 805-820 (2017)
Nineteen new compounds containing tetrazole and/or cyanamide moiety have been designed and synthesised. Their structures were confirmed using spectroscopic methods and elemental analyses. Anti-inflammatory activity for all the synthesised compounds w
Externí odkaz: https://doaj.org/article/950c0a3e47da4edd88afd02c9cafc85d
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6
Akademický článek
Design, Synthesis and Evaluation of Novel Phthalimide Derivatives as in Vitro Anti-Microbial, Anti-Oxidant and Anti-Inflammatory Agents
Autor: Phoebe F. Lamie, John N. Philoppes, Ahmed O. El-Gendy, Lucie Rarova, Jiri Gruz
Publikováno v: Molecules, Vol 20, Iss 9, Pp 16620-16642 (2015)
Sixteen new phthalimide derivatives were synthesized and evaluated for their in vitro anti-microbial, anti-oxidant and anti-inflammatory activities. The cytotoxicity for all synthesized compounds was also determined in cancer cell lines and in normal
Externí odkaz: https://doaj.org/article/f9e6290f029e4c5f8350b83bfcd65991
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8
Akademický článek
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9
Design, synthesis, and biological evaluation of novel pyrido-dipyrimidines as dual topoisomerase II/FLT3 inhibitors in leukemia cells
Autor: Mohamed A. Abdelgawad, Fatma E.A. Mohamed, Phoebe F. Lamie, Syed N.A. Bukhari, Mohammad M. Al-Sanea, Arafa Musa, Mohammed Elmowafy, A.A. Nayl, Ahmed Karam Farag, Sameeha M. Ali, Mohamed E. Shaker, Hany A. Omar, Mohammed K. Abdelhameid, Manal M. Kandeel
Publikováno v: Bioorganic chemistry. 122
Dual inhibition of topoisomerase (topo) II and FLT3 kinase, as in the case of C-1311, was shown to overcome the shortcomings of using topo II inhibitors solely. In the present study, we designed and synthesized two series of pyrido-dipyrimidine- and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92674afee7098a8e59580bba3694548e
https://pubmed.ncbi.nlm.nih.gov/35339926
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10
COX-1/COX-2 inhibition assays and histopathological study of the new designed anti-inflammatory agent with a pyrazolopyrimidine core
Autor: Eman K. A. Abdelall, Phoebe F. Lamie, El-Shaymaa El-Nahass, Amira K.M. Ahmed
Publikováno v: Bioorganic Chemistry. 86:235-253
Four pyrazolopyrimidine series were prepared with a substitution at position- 4 by Schiff base, triazole, oxadiazole and pyrazole moieties (7a-f, 8a,b, 9a-f, 10a,b and 13a,b), respectively. All the synthesized compounds were evaluated in vitro agains
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fce431b1b25a7bc90d233766a90df9
https://doi.org/10.1016/j.bioorg.2019.01.031
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