Zobrazeno 1 - 10
of 18
pro vyhledávání: '"F. L. Wessels"'
Publikováno v:
Journal of Pharmaceutical Sciences. 69:1198-1202
1-(3,4-dichlorobenzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidone (I) was evaluated in selected pharmacological tests, and its activity was compared to that of some clinically useful psychotropic drugs. Based on the results, it is evident that I has a uniqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b928d551d372a8739b3cb36d6c66e239
https://doi.org/10.1002/jps.2600691021
https://doi.org/10.1002/jps.2600691021
Autor:
K. O. Ellis, F. L. Wessels
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 301:237-240
Identified metabolites of dantrolene, a skeletal muscle relaxant, were studied for inhibition of skeletal muscle contractions. Inhibition of muscle contractions were studied in vivo in the rat gastrocnemius muscle preparation, and in vitro using isol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a494aee44b562e350358dfbddcfb49ce
https://doi.org/10.1007/bf00507042
https://doi.org/10.1007/bf00507042
Publikováno v:
Journal of Pharmaceutical Sciences. 69:327-331
A series of quaternary ammonium salts of dantrolene and clodanolene was prepared and evaluated for skeletal muscle relaxant activity. The quaternary ammonium salts exhibit greater aqueous solubility and, therefore, facilitate intravenous administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55e628474529dba63c8a9d16a99633b
https://doi.org/10.1002/jps.2600690319
https://doi.org/10.1002/jps.2600690319
Publikováno v:
Journal of Pharmaceutical Sciences. 69:1194-1198
A series of 1-(substituted benzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidones was synthesized primarily by catalytic hydrogenation of the corresponding 1-(substituted benzyl)-2(1H)-pyrimidone. The pharmacological evaluation of these compounds in mice revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791fbd893b0875b61efb15b3c591ec9e
https://doi.org/10.1002/jps.2600691020
https://doi.org/10.1002/jps.2600691020
Publikováno v:
Journal of Pharmaceutical Sciences. 62:948-951
Dantrolene causes skeletal muscle relaxation in animals without prominent CNS actions, and it has little or no measurable effect on smooth or cardiac muscle. Dantrolene reduces rigidity in decerebrate cats. Unlike centrally acting muscle relaxants, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371ede5335cca974b8e581d79e8389f0
https://doi.org/10.1002/jps.2600620619
https://doi.org/10.1002/jps.2600620619
Publikováno v:
Journal of Pharmaceutical Sciences. 69:1102-1104
5-(4-Dimethylaminobenzyl)imidazolidine-2,4-dione was prepared by catalytic hydrogenation of the corresponding benzylidene compound. Antidepressant testing in mice indicated that its ED50 values for antagonism of tetrabenazine-induced ptosis and poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c151333161975cdb433632ef0e6041c3
https://doi.org/10.1002/jps.2600690933
https://doi.org/10.1002/jps.2600690933
Publikováno v:
Chemischer Informationsdienst. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03e53d04ad02637e3f1fabb8bf7e424d
https://doi.org/10.1002/chin.198032206
https://doi.org/10.1002/chin.198032206
Publikováno v:
Journal of medicinal chemistry. 21(1)
A series of 5-hydroxy substitution products of 2,4-imidazolidinediones, including the 5-hydroxy metabolite of the skeletal muscle contraction antagonist, dantrolene sodium, has been synthesized and evaluated for skeletal muscle relaxant activity. Mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133527d75829550138fb2ca3750bc07a
https://pubmed.ncbi.nlm.nih.gov/619142
https://pubmed.ncbi.nlm.nih.gov/619142
Publikováno v:
Chemischer Informationsdienst. 12
A series of 1-(substituted benzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidonea was synthesized primarily by catalytic hydrogenation of the corresponding 1-(substituted benzyl)-2(1H)-pyrimidone. The pharmacological evaluation of these compounds in mice revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcde8a5680d8d1f8bb52bd1630649337
https://doi.org/10.1002/chin.198115261
https://doi.org/10.1002/chin.198115261
Publikováno v:
Journal of medicinal chemistry. 30(2)
A series of 1-[[[5-(substituted phenyl)-2-oxazolyl]methylene]amino]- 2,4-imidazolidinediones (6a-t) was synthesized, and the compounds were evaluated for direct skeletal muscle inhibition in the pithed rat gastrocnemius muscle preparation. The correc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950e491b0a016c8c5b76e6f6f51d1551
https://pubmed.ncbi.nlm.nih.gov/3806610
https://pubmed.ncbi.nlm.nih.gov/3806610