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pro vyhledávání: '"F. L. Tyson"'
Autor:
E, Wickstrom, F L, Tyson
Publikováno v:
Ciba Foundation symposium. 209
The usual course of drug discovery begins with the demonstration of compound activity in cells and, usually, a lower level of activity in animals. Successive rounds of drug design may result in a compound with sufficient activity in animals to justif
Autor:
C R, Herzog, E V, Soloff, A L, McDoniels, F L, Tyson, A M, Malkinson, A, Haugen-Strano, R W, Wiseman, M W, Anderson, M, You
Publikováno v:
Oncogene. 13(9)
The genes of murine cyclin D-dependent kinase inhibitors, p15INK4b and p16INK4a, are located in a region of chromosome 4 where overlapping deletions were found in lung adenocarcinomas. The p16INK4a gene uniquely consists of alternative first exons (E
Publikováno v:
BioTechniques. 14(3)
The PCR has proven to be useful in the analysis of gene expression of specific mRNAs. Although PCR is able to detect rare mRNA transcripts following reverse transcription PCR, determining relative or absolute copy number can be difficult due to sampl
Autor:
Lee Daly, John T. Soper, G. Cram, Jennie R. Crews, Russel E. Kaufman, Cinda M. Boyer, Kathy O'Briant, J. S. Haskill, W. C. Fowler, Robert C. Bast, F. L. Tyson
Publikováno v:
American journal of obstetrics and gynecology. 165(3)
Amplification of the c-erbB-2 protooncogene has been associated with a poor prognosis in human breast and ovarian cancers. Our study was undertaken to examine whether amplification, rearrangement, or overexpression of c-erbB-2 and other protooncogene