Zobrazeno 1 - 10 of 10 pro vyhledávání: '"F. L. Douglas"'
2
Effect of chronic hypertension on the blood-brain barrier permeability of libenzapril
Autor: J P, Tang, A, Rakhit, F L, Douglas, S, Melethil
Publikováno v: Pharmaceutical research. 9(2)
Very little information is available on the permeability of the blood-brain barrier (BBB) to small polar drugs in chronic hypertension. The blood and cerebrospinal fluid (CSF) pharmacokinetics of libenzapril (LZP), a potent angiotensin converting enz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ba1cbbd6b20bf3d44e77b426345e089
https://pubmed.ncbi.nlm.nih.gov/1553348
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3
Determination of in vivo hepatic extraction ratio from in vitro metabolism by rat hepatocytes
Autor: K, Singh, S L, Tripp, A W, Dunton, F L, Douglas, A, Rakhit
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 19(5)
Using isolated rat hepatocytes, the in vitro intrinsic hepatic clearance of three drugs, namely, antipyrine (AP), propranolol (P), and CGS 13429 was determined. The hepatic extraction ratios of AP, P, and CGS 13429 were then calculated to be 0.10, 0.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::224fed023b1d86d405cc538b024a2d8b
https://pubmed.ncbi.nlm.nih.gov/1686248
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5
Pharmacokinetic screening of o-naphthoquinone 5-lipoxygenase inhibitors
Autor: A, Rakhit, S K, Kuwahara, D R, Jones, V F, Soliman, A N, Kotake, T D, Oglesby, J W, Wasley, S L, Tripp, F L, Douglas
Publikováno v: Pharmaceutical research. 7(10)
The o-naphthoquinone derivative, CGS 8515 (I), is a potent inhibitor (IC50, 0.1 microM) of 5-lipoxygenase, but its therapeutic potential is compromised by a short plasma half-life (22 min) and extremely poor oral bioavailability (less than 2%). Poor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::edfdcc0a921b34fc064603372d62f985
https://pubmed.ncbi.nlm.nih.gov/2281039
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6
Metabolic and hemodynamic effects of magnesium supplementation in patients with essential hypertension
Autor: F L Douglas, Michael B. Zemel, Martin Urberg, R Geiser, James R. Sowers, Paula Zemel
Publikováno v: The American journal of clinical nutrition. 51(4)
The effect of magnesium supplementation on blood pressure, erythrocyte cation metabolism, and serum lipids was evaluated in 13 patients with mild hypertension. After randomization and a 3-wk placebo run-in period, seven patients received 40 mmol Mg a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d9e909085c7394c8669b81eafe5e16
https://pubmed.ncbi.nlm.nih.gov/2181860
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7
Comparison of Thromboxane Synthetase Inhibitor and Methylprednisolone Effects on Protamine Responses in Dogs
Autor: T. A. Burke, A V Schaffer, J Peppard, T Viswanathan, F L Douglas, Young D. Kim, J S Fomsgaard, M.R Danchak, Adam K. Myers
Publikováno v: Anesthesia & Analgesia. 74:38
Neutralization of heparin anticoagulation by protamine produces catastrophic hemodynamic reactions in some patients. Using a canine model, we tested effects of thromboxane synthetase inhibition (CGS-13080) and glucocorticoid pretreatment on the cardi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5446ba44763361f6b47f56fa3b585903
https://doi.org/10.1213/00000539-199201000-00007
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8
Selective antagonism of the hypotensive effects of dopamine agonists in spontaneously hypertensive rats
Autor: C E McCoy, F L Douglas, Leon I. Goldberg
Publikováno v: Hypertension. 8:298-302
Agonists of dopamine receptors can lower blood pressure by vasodilation through action on dopamine1 receptors, inhibition of sympathetic nerve activity by action on dopamine2 receptors, or actions in the central nervous system. Fenoldopam, a selectiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0922bc6434c69a3ec0dc39759cdbefab
https://doi.org/10.1161/01.hyp.8.4.298
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9
Augmentation of renal blood flow and sodium excretion in hypertensive patients during blood pressure reduction by intravenous administration of the dopamine1 agonist fenoldopam
Autor: F L Douglas, Leon I. Goldberg, E D Frederickson, Michael B. Murphy, C E McCoy, R R Weber
Publikováno v: Circulation. 76:1312-1318
Activation of dopamine1 (DA1) receptors relaxes vascular smooth muscle, especially in the renal vascular bed. Fenoldopam, the first selective DA1-receptor agonist that can be administered to man, was infused intravenously in 17 patients with essentia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96a841f99847eed0eda63515477b2f6
https://doi.org/10.1161/01.cir.76.6.1312
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10
Effects of long-term therapy with oral ibopamine on resting hemodynamics and exercise capacity in patients with heart failure: relationship to the generation of N-methyldopamine and to plasma norepinephrine levels
Autor: Sol I. Rajfer, Theodore Karrison, Leon I. Goldberg, James D. Rossen, F L Douglas
Publikováno v: Circulation. 73(4)
N-Methyldopamine (epinine), one of the few modifications of the dopamine (DA) molecule that retains agonist activity at the DA1 receptor, was administered orally as the diisobutyric ester, ibopamine (100, 200, and 300 mg), to 15 patients with congest
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd2ee8e6eec3f0b4f6de4d8b2fc0c45
https://pubmed.ncbi.nlm.nih.gov/3948372
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