Zobrazeno 1 - 10
of 99
pro vyhledávání: '"F. Kokai and"'
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 17, Iss 9, Pp 2873-2893 (2021)
The emergence of the novel SARS-CoV-2 and COVID-19 has brought into sharp focus the need for a vaccine to prevent this disease. Vaccines have saved millions of lives since their introduction to the public over 200 years ago. The potential for vaccina
Externí odkaz:
https://doaj.org/article/05bcaaf718454b3093d0c4bd14ae58e8
Publikováno v:
Human Vaccines & Immunotherapeutics
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The emergence of the novel SARS-CoV-2 and COVID-19 has brought into sharp focus the need for a vaccine to prevent this disease. Vaccines have saved millions of lives since their introduction to the public over 200 years ago. The potential for vaccina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e72a8f27d2c8a407898cf24d8ad78fb
https://doi.org/10.1080/21645515.2021.1911204
https://doi.org/10.1080/21645515.2021.1911204
Autor:
Hao Chen, Walker J. Turner, Sanquan Song, Keren Zhu, George F. Kokai, Brian Zimmer, C. Thomas Gray, Brucek Khailany, David Z. Pan, Haoxing Ren
Publikováno v:
Proceedings of the 2022 International Symposium on Physical Design.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3a4c60316e8c638f4c6100bb003e4b8
https://doi.org/10.1145/3505170.3511044
https://doi.org/10.1145/3505170.3511044
Autor:
Nadim J. Ajami, Chenxiong Le, Julia L. Cope, Kenneth Trout, Andrew J Degar, Sheila Connelly, John F. Kokai-Kun
Publikováno v:
Infection and Drug Resistance
Introduction Intravenous (IV) β-lactam antibiotics, excreted through bile into the gastrointestinal (GI) tract, may disrupt the gut microbiome by eliminating the colonization resistance from beneficial bacteria. This increases the risk for Clostridi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1eb062667ae8674800094b47ea33d2b
https://doi.org/10.2147/idr.s260258
https://doi.org/10.2147/idr.s260258
Publikováno v:
DATE
Layout parasitics significantly impact the performance of analog integrated circuits, leading to discrepancies between schematic and post-layout performance and requiring several iterations to achieve design convergence. Prior work has accounted for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d42af9562d9504bafd7af3625c1ff1f1
https://doi.org/10.23919/date51398.2021.9474253
https://doi.org/10.23919/date51398.2021.9474253
Publikováno v:
DAC
Layout-dependent parasitics and device parameters significantly impact integrated circuit performance and are often the cause of slow convergences between schematic and layout designs. Circuit designers typically estimate parasitics from past experie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460b88348c693483266e5ac6f0918e90
https://doi.org/10.1109/dac18072.2020.9218515
https://doi.org/10.1109/dac18072.2020.9218515
Publikováno v:
Anaerobe. 53:30-33
During a Phase 2b study with SYN-004 (ribaxamase) for prevention of Clostridium difficile infection (CDI) conducted in North America and Eastern Europe, 45 C. difficile isolates from subjects with laboratory-confirmed CDI and or colonized with C. dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca0e78e4465e3cab86754c234de45de
https://doi.org/10.1016/j.anaerobe.2018.07.002
https://doi.org/10.1016/j.anaerobe.2018.07.002
Autor:
Steven Hubert, John F. Kokai-Kun, Giovanni Widmer, Annie Jones, Todd Parsley, Nur A. Hasan, Sheila Connelly, Perrti Koski, J. Andrew Bristol, Michael Kaleko, Saul Tzipori, Poorani Subramanian, Joseph Sliman
Publikováno v:
Anaerobe. 41:58-67
The gut microbiome, composed of the microflora that inhabit the gastrointestinal tract and their genomes, make up a complex ecosystem that can be disrupted by antibiotic use. The ensuing dysbiosis is conducive to the emergence of opportunistic pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd00bc23048fef79afda3d09e5e11d1
Autor:
J. Andrew Bristol, Heidi Whalen, John F. Kokai-Kun, Joseph Sliman, Kenneth C. Lasseter, Olivia Coughlin, Tracey Roberts, Steven Hubert, Barbara Valero Lopez, James Longstreth
Publikováno v:
Clinical Drug Investigation. 36:725-734
SYN-004 is an orally administered β-lactamase enzyme, designed to be given concurrently with certain intravenous β-lactam antibiotics like cephalosporins. SYN-004 is intended to degrade residual antibiotics excreted into the intestine as a result o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1f60974d01086422b6d69cce43c547
https://doi.org/10.1007/s40261-016-0420-0
https://doi.org/10.1007/s40261-016-0420-0
Autor:
Vincent J. Wacher, Tracey M. Roberts, Olivia Coughlin, Heidi Whalen, John F. Kokai-Kun, Joseph Sliman, Ralph Stevenson, Chenxiong (Charles) Le
Publikováno v:
The Lancet. Infectious diseases. 19(5)
Infections with Clostridium difficile are a health threat, yet no products are currently licensed for prevention of primary C difficile infections. Intravenous β-lactam antibiotics are considered to confer a high risk of C difficile infection becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6337d9ea89986147a7e037836d826697
https://pubmed.ncbi.nlm.nih.gov/30885590
https://pubmed.ncbi.nlm.nih.gov/30885590