Zobrazeno 1 - 10
of 676
pro vyhledávání: '"F. Kearney"'
Publikováno v:
Journal of Dairy Science, Vol 106, Iss 12, Pp 9778-9792 (2023)
ABSTRACT: The aims of this study were (1) to evaluate potential associations between genetic traits, postpartum phenotypes, cow factors, and postpartum vaginal discharge score (VDS); and (2) to investigate possible associations between postpartum VDS
Externí odkaz:
https://doaj.org/article/dc5bf2a653834e6593a7774e5948418a
Autor:
Yury V. Kuzmichev, Carol Lackman-Smith, Sonia Bakkour, Ann Wiegand, Michael J. Bale, Andrew Musick, Wendy Bernstein, Naomi Aronson, Julie Ake, Sodsai Tovanabutra, Mars Stone, Roger G. Ptak, Mary F. Kearney, Michael P. Busch, Elizabeth R. Wonderlich, Deanna A. Kulpa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The advent of combined antiretroviral therapy (cART) has been instrumental in controlling HIV-1 replication and transmission and decreasing associated morbidity and mortality. However, cART alone is not able to cure HIV-1 due to the presence
Externí odkaz:
https://doaj.org/article/545480fa87244f56b8e17d09e2796b5a
Autor:
Johannes C. Botha, Dimiter Demirov, Carli Gordijn, Mary Grace Katusiime, Michael J. Bale, Xiaolin Wu, Daria Wells, Stephen H. Hughes, Mark F. Cotton, John W. Mellors, Mary F. Kearney, Gert U. van Zyl
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Combination antiretroviral therapy (cART) suppresses viral replication but does not cure HIV infection because a reservoir of infectious (intact) HIV proviruses persists in long-lived CD4+T cells. However, a large majority (>95%) of HIV-infe
Externí odkaz:
https://doaj.org/article/d5d9f7ebe1244d2c9af51df313d4cec7
Autor:
Debasish Chattopadhyay, Dionna R. Walker, Shane T. Rich-New, John F. Kearney, Charles L. Turnbough, Jr.
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT The outermost exosporium layer of Bacillus anthracis spores, the causative agents of anthrax, is comprised of a basal layer and an external hair-like nap. The nap includes filaments composed of trimers of the collagen-like glycoprotein BclA.
Externí odkaz:
https://doaj.org/article/45d3d15e6407479a9bda4afdca590df8
Autor:
Hector Cordero, Rodney G. King, Pranay Dogra, Chloe Dufeu, Sarah B. See, Alexander M. Chong, Anne-Catrin Uhlemann, Siu-Hong Ho, David M. Kalfa, Emile A. Bacha, John F. Kearney, Emmanuel Zorn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The thymus is known as the organ of T lymphocyte development. Here authors show that terminal B cell differentiation also takes place in the thymus of human neonates, leading to antibody production against commensal and pathogenic bacteria.
Externí odkaz:
https://doaj.org/article/e3974adc67504d398d0283ef6c71a113
Autor:
Imogen A. Wright, Michael J. Bale, Wei Shao, Wei-Shau Hu, John M. Coffin, Gert U. Van Zyl, Mary F. Kearney
Publikováno v:
Retrovirology, Vol 18, Iss 1, Pp 1-6 (2021)
Abstract The characterisation of the HIV-1 reservoir, which consists of replication-competent integrated proviruses that persist on antiretroviral therapy (ART), is made difficult by the rarity of intact proviruses relative to those that are defectiv
Externí odkaz:
https://doaj.org/article/f0403fb048314b8bad0786d7ae4c20b2
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is notorious for a dense fibrotic stroma that is interlaced with a collagen-based extracellular matrix (ECM) that plays an important role in tumor biology. Traditionally thought to only provide a physical barri
Externí odkaz:
https://doaj.org/article/2e12b72ac7d0456381dd8495ea0e038d
Publikováno v:
Genetics Selection Evolution, Vol 51, Iss 1, Pp 1-11 (2019)
Abstract Background In modern dairy breeding programmes, high contributions from foreign sires are nearly always present. Genotyping, and therefore genomic selection (GS), concern only a subpopulation of the breeding programme’s wider dairy populat
Externí odkaz:
https://doaj.org/article/d42739f269f7480c9b0c7b988e8eb466
Autor:
John M Coffin, Michael J Bale, Daria Wells, Shuang Guo, Brian Luke, Jennifer M Zerbato, Michele D Sobolewski, Twan Sia, Wei Shao, Xiaolin Wu, Frank Maldarelli, Mary F Kearney, John W Mellors, Stephen H Hughes
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009141 (2021)
HIV persists during antiretroviral therapy (ART) as integrated proviruses in cells descended from a small fraction of the CD4+ T cells infected prior to the initiation of ART. To better understand what controls HIV persistence and the distribution of
Externí odkaz:
https://doaj.org/article/3e177632677e4f3b9ab7e952f1029063
Autor:
Michael J. Bale, Mary Grace Katusiime, Daria Wells, Xiaolin Wu, Jonathan Spindler, Elias K. Halvas, Joshua C. Cyktor, Ann Wiegand, Wei Shao, Mark F. Cotton, Stephen H. Hughes, John W. Mellors, John M. Coffin, Gert U. Van Zyl, Mary F. Kearney
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
HIV-1 integrates its genome into the DNA of host cells. Consequently, HIV-1 genomes are copied with the host cell DNA during cellular division.
Externí odkaz:
https://doaj.org/article/24168db87d274281ba8cf37cddd5815b