Zobrazeno 1 - 10 of 18 pro vyhledávání: '"F. K. Mutulis"'
1
[Cyclic analogs of substance P. III. Cyclo (6(sup)gamma----oligomethylenediamine----11) substance P(6-11)-hexapeptides]
Autor: F K, Mutulis, I E, Mutule, G Kh, Maurops, Iu, Bergmann, N V, Myshliakova, G M, Strazda, E E, Liepin'sh, Iu B, Saulitis, V D, Grigor'eva, Iu Iu, Balodis
Publikováno v: Bioorganicheskaia khimiia. 17(10)
Cyclic analogues of substance P of the formula cyclo-[Glu-Phe-Phe-Gly-Leu-Met-NH(CH2)nNH-], where n = 3-10, 12, and open-chain analogues (XVIIIa, b) H-Glu.(NHR)-Phe-Phe-Gly-Leu-Met-NHR, where R = -CH3, -CH2CH2CH3, were synthesized. By NMR spectroscop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::34c0f695f8f3672d0106e92173dd18db
https://pubmed.ncbi.nlm.nih.gov/1725106
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2
[Cyclic analogs of bradykinin, containing a carboxyl group]
Autor: I E, Mutule, F K, Mutulis, N V, Myshliakova, M M, Veveris, V V, Golubeva, E A, Porunkevich, M P, Ratkevich, G M, Strazda, V E, Klusha, Iu, Bergmann
Publikováno v: Bioorganicheskaia khimiia. 16(11)
1 alpha-beta-carboxypropionyl-cyclo(9----1 epsilon)-[Lys1, Gly6]bradykinin (Suc-c[Lys1, Gly6]B), 1 alpha-beta-carboxypropionyl-cyclo(10----1 epsilon)kallidin (Suc-cK), cyclo(10 gamma----1 epsilon)-[Glu10]kallidin (c[Glu10]K) and cyclo(11 gamma----1 e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a51234c67d491190d3dc2a6a9936cd21
https://pubmed.ncbi.nlm.nih.gov/1710895
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3
[General principles of mast cell activation by cyclic analogs of basic vasoactive peptides]
Autor: E A, Porunkevich, M P, Ratkevich, G G, Kublis, F K, Mutulis, G I, Chipens
Publikováno v: Biokhimiia (Moscow, Russia). 55(6)
The histamine-releasing activity of some linear and cyclic analogues of bradykinin (BK) and kallidin (K) was studied on rat peritoneal mast cells and compared with that of angiotensin (AT) cycloanalogues assayed earlier. Peptide cyclization, irrespec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c06a11d810f6ad055fe639b4cc40aac
https://pubmed.ncbi.nlm.nih.gov/1698465
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4
Mechanism of action of cyclokinins
Autor: N. V. Myshlyakova, R. O. Vitolinya, V. V. Golubeva, G. A. Afanas'eva, V. E. Klusha, F. K. Mutulis, I. �. Mutule, G. I. Chipens
Publikováno v: Bulletin of Experimental Biology and Medicine. 96:1574-1577
Cyclic analogs of bradykinin (CBK) and kallidin (CK) have a weak myotropic activity and a marked and prolonged hypotensive effect unlike linear bradykinin (BK) and kallidin (K) which produce a short-term hypotension and considerable contraction of ra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ae8fe53f1896f14d20388a6ae4d1998
https://doi.org/10.1007/bf00835294
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5
Synthesis of C-terminal fragments of bombesin and their analogues
Autor: I. L. Kuranova, V. L. Dyudmirova, Filonova Eb, F. K. Mutulis, S. I. Churkina, Grigor'eva Vd, I. P. Sekatsis, F. M. Ibatullin
Publikováno v: Chemistry of Natural Compounds. 25:475-484
With the aim of structural-functional studies in the bombesin series, a number of bombesin fragments and analogues have been synthesized. The synthesis was performed by the carbodiimide method and by the activated-ester method. Fragments with the seq
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a30d8396a38bde23f6a61ef32d1ecba5
https://doi.org/10.1007/bf00597661
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6
[Cyclic analogs of substance P. I. Cyclo(11----epsilon 5)-[Lys5] substance P-(5-11)]
Autor: G Kh, Maurops, F K, Mutulis, S Kh, Rozite, N V, Myshliakova, Sh V, Svirskis
Publikováno v: Bioorganicheskaia khimiia. 13(12)
Two solution syntheses of cyclo(11----5 epsilon)-[Lys5]substance P-(5-11) (CLP) were carried out. The first synthesis involved the stepwise elongation of the peptide chain starting from glycine tert-butyl ester. At the stage of hexapeptide deprotecti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d29204564dd27f12cbdd33a7c29d41f
https://pubmed.ncbi.nlm.nih.gov/2453193
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8
[Study of bradykinin conformation in a dimethylsulfoxide solution by two-dimensional 1H-NMR spectroscopy]
Autor: Iu B, Saulitis, E E, Liepin'sh, I P, Sekatsis, F K, Mutulis, G I, Chipens
Publikováno v: Bioorganicheskaia khimiia. 12(4)
The role of charged groups of the nonapeptide bradykinin in stabilization of its spatial structure in dimethyl sulfoxide solution was investigated. The signal assignment in the 1H-NMR spectra was achieved by means of two dimensional correlated spectr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ad112a891f0eceeef342bb9958d6351
https://pubmed.ncbi.nlm.nih.gov/3718546
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10
[Effective synthesis of cyclic analogs of bradykinin]
Autor: I E, Mutule, F K, Mutulis, D P, Erglis, D A, Iakstrinia, I P, Sekatsis
Publikováno v: Bioorganicheskaia khimiia. 14(3)
Cyclo-epsilon-(L-lysine1, glycine6-bradykinin) (CLGB) and cyclo-epsilon-kallidin have been synthesised in solution. To prepare linear precursors, fragment condensation (3 + 3 or 4) + 3 was used. Peptide bond formation, including cyclization, was carr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::941729210f01df55301abc7888089a8b
https://pubmed.ncbi.nlm.nih.gov/3382439
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