Výsledky vyhledávání - "F. J. P. Höppener"

Low doses of the novel caspase-inhibitor GS-9450 leads to lower caspase-3 and -8 expression on peripheral CD4+ and CD8+ T-cells

Autor: Andy I. M. Hoepelman, F. J. P. Höppener, K. R. Hirsch, Joop E. Arends, Nening M. Nanlohy, J. G. Park, D. van Baarle

Publikováno v: Apoptosis, 16(9), 959-66
Apoptosis

Chronic hepatitis C virus (HCV) infection is characterized by increased rates of apoptotic hepatocytes and activated caspases have been shown in HCV-infected patients. GS-9450, a novel caspase-inhibitor has demonstrated hepatoprotective activity in f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb3d20eea3db9c1aac8e2db19f2498b
https://research.rug.nl/en/publications/0f1e5e27-d091-47da-89b5-1eb8947e30d5

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Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin

Autor: D.Th. Sleijfer, Phb Willemse, F J P Höppener, R.S. de Jong, Nh Mulder, Dra Uges, W.T.A. van der Graaf, E.G.E. de Vries, Harry J.M. Groen

Publikováno v: British Jounal of Cancer, 79(5-6), 882-887. Nature Publishing Group
British Journal of Cancer

We conducted a phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. Fostriecin was administered intravenously over 60 min on days 1–5 at 4-week intervals. Dose was escalated from 2 mg m−2day−1to 20 mg m−2d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae146fbc3d7c1bb55508f3cdc6eb8b2
https://doi.org/10.1038/sj.bjc.6690141

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