Zobrazeno 1 - 10
of 90
pro vyhledávání: '"F. J. Karsch"'
Publikováno v:
Bioscientifica Proceedings.
This article reviews experiments performed to investigate the importance of thyroid hormones to the expression of the seasonal reproductive cycle of ewes. Thyroidectomy was found to block the transition from the breeding season to anoestrus and to ca
Publikováno v:
Endocrinology. 136:2412-2420
This study was designed to test the hypothesis that endogenous opioid peptides (EOP) mediate the negative feedback action of estradiol on GnRH pulse size in breeding season ewes. If this hypothesis is correct, one would predict that an EOP antagonist
Publikováno v:
Reproduction (Cambridge, England). Supplement. 61
Stress influences the activity of the reproductive system at several sites. One of the most significant effects is at level of the GnRH secretory system to reduce GnRH pulsatility and thus LH pulsatility. This in turn reduces the oestradiol signal th
Publikováno v:
Reproduction (Cambridge, England). Supplement. 59
Seasonally breeding mammals display an annual cycle of fertility that is associated with both structural neuroplasticity and functional changes in the activity of the GnRH neurones in the brain. Sheep are valuable models for understanding the hormona
Publikováno v:
Reproduction (Cambridge, England). Supplement. 59
FSH is a key reproductive hormone involved in the control of ovarian folliculogenesis and steroidogenesis. Multiple regulatory mechanisms govern the release of FSH. These regulatory mechanisms appear to work in concert to modulate the level, pattern
Autor:
F J, Karsch, D F, Battaglia
Publikováno v:
Reproduction (Cambridge, England). Supplement. 59
This review summarizes a series of experiments that address mechanisms by which endotoxin, a commonly used model of immune/inflammatory challenge, disrupts the oestrous cycle of the ewe. Initial studies in ovariectomized ewes demonstrated that endoto
Publikováno v:
Endocrinology. 142(5)
Immune/inflammatory challenges powerfully suppress reproductive neuroendocrine activity. This inhibition is generally considered to be centrally mediated via mechanisms that regulate GnRH secretion. The present study provides two lines of evidence th
Publikováno v:
Biology of reproduction. 63(3)
An endogenous circannual rhythm drives the seasonal reproductive cycle of a broad spectrum of species. This rhythm is synchronized to the seasons (i.e., entrained) by photoperiod, which acts by regulating the circadian pattern of melatonin secretion
Publikováno v:
Biology of reproduction. 62(1)
Two experiments were conducted to investigate endocrine mechanisms by which the immune/inflammatory stimulus endotoxin disrupts the follicular phase of the estrous cycle of the ewe. In both studies, endotoxin was infused i.v. (300 ng/kg per hour) for
Publikováno v:
Endocrinology. 139(10)
We tested the hypothesis that systemic immune/inflammatory challenge (endotoxin) activates the neuroendocrine stress axis centrally by stimulating the secretion of CRH and arginine vasopressin (AVP) into hypophyseal portal blood. In addition, we exam