Zobrazeno 1 - 6 of 6 pro vyhledávání: '"F. J. Hollis"'
1
Metabolic and pharmacokinetic studies following oral administration of famciclovir to the rat and dog
Autor: S. E. Fowles, T. A. Brown, J. V. Ramji, E. E. Mort, G. D. Allen, F. J. Hollis, C. W. Filer
Publikováno v: Xenobiotica. 25:477-490
1. Drug-related material was well absorbed following oral administration of 14C-famciclovir to the male rat at doses up to 4000 mg/kg and to the male dog at doses up to 250 mg/kg, as judged by the early onset of the peak blood or plasma concentration
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5e2e1e45640f26450d48fbe09c33d7
https://doi.org/10.3109/00498259509061867
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2
Metabolism and disposition of14C-granisetron in rat, dog and man after intravenous and oral dosing
Autor: F. J. Hollis, M. Nash, S. E. Clarke, F. R. Woods, P. C. Shardlow, T. C. Tasker, J. C. Bloomer, R. E. Haddock, G. D. Allen, N. E. Austin, F. C. Higham
Publikováno v: Xenobiotica. 24:1119-1131
1. The disposition and metabolic fate of 14C-granisetron, a novel 5-HT3 antagonist, was studied in rat, dog, and male human volunteers after intravenous and oral administration. 2. Complete absorption occurred from the gastrointestinal tract followin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2af62345c076a81aa6cb2cf22fd6a8
https://doi.org/10.3109/00498259409038671
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3
The disposition of gemifloxacin, a new fluoroquinolone antibiotic, in rats and dogs
Autor: J V, Ramji, N E, Austin, G W, Boyle, M H, Chalker, G, Duncan, A J, Fairless, F J, Hollis, D F, McDonnell, T J, Musick, P C, Shardlow
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(4 Pt 1)
Gemifloxacin is a fluoroquinolone antibacterial compound with enhanced affinity for bacterial topoisomerase IV and is being developed for the treatment of respiratory and urinary tract infections. The disposition and metabolic fate of this antibiotic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b92a7c296b1a808fbd6e3ec54ba4fac1
https://pubmed.ncbi.nlm.nih.gov/11259328
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4
Absorption, disposition, and metabolism of rosiglitazone, a potent thiazolidinedione insulin sensitizer, in humans
Autor: P J, Cox, D A, Ryan, F J, Hollis, A M, Harris, A K, Miller, M, Vousden, H, Cowley
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 28(7)
Rosiglitazone is a potent peroxisome proliferator-activated receptor gamma agonist that decreases hyperglycemia by reducing insulin resistance in patients with type 2 diabetes mellitus. The disposition of (14)C-labeled rosiglitazone was determined af
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b658b370cd087355670768279e6ee2c4
https://pubmed.ncbi.nlm.nih.gov/10859151
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5
Metabolic and pharmacokinetic studies following oral administration of 14C-famciclovir to healthy subjects
Autor: F. J. Hollis, W. T. Prince, S. E. Fowles, G. D. Allen, T. A. Brown, E. E. Mort, J. V. Ramji, C. W. Filer
Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 24(4)
1. Following oral administration of 14C-famciclovir (500 mg) to three healthy male subjects, drug-related material was rapidly absorbed as judged by peak plasma concentrations of radioactive material being achieved by 0.75 h (6.7 +/- 0.9 microgram eq
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8941a2d90071f955ef3916aa291119
https://pubmed.ncbi.nlm.nih.gov/8059539
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