Zobrazeno 1 - 10
of 11
pro vyhledávání: '"F. J. Helmstetter"'
Autor:
Lars Richter, Gerhard F. Ecker, Michael W. Parker, Catherine C. Kaczorowski, J. L. Chen, Margot Ernst, Brett A. Cromer, Werner Sieghart, F. J. Helmstetter, H.-L. Ng, Craig J. Morton, Roman Furtmüller, James M. Cook, Terrill Scott Clayton
Publikováno v:
Current Medicinal Chemistry. 14:2755-2775
A successful unified pharmacophore/receptor model which has guided the synthesis of subtype selective compounds is reviewed in light of recent developments both in ligand synthesis and structural studies of the binding site itself. The evaluation of
Autor:
T, Clayton, J L, Chen, M, Ernst, L, Richter, B A, Cromer, C J, Morton, H, Ng, C C, Kaczorowski, F J, Helmstetter, R, Furtmüller, G, Ecker, M W, Parker, W, Sieghart, J M, Cook
Publikováno v:
Current medicinal chemistry. 14(26)
A successful unified pharmacophore/receptor model which has guided the synthesis of subtype selective compounds is reviewed in light of recent developments both in ligand synthesis and structural studies of the binding site itself. The evaluation of
Publikováno v:
Behavioral neuroscience. 113(2)
In this study, the role of mRNA synthesis in the amygdala was studied during the acquisition of conditional fear. Rats with cannulas placed in the basolateral region of the amygdala were trained with a series of noise-shock pairings in a distinctive
Autor:
P S, Bellgowan, F J, Helmstetter
Publikováno v:
Behavioral neuroscience. 110(4)
A single brief exposure to moderately intense while noise is sufficient to produce opioid-mediated antinociception in rats. This form of stress-induced hypoalgesia represents a response to unconditional fear or anxiety. Three experiments compared the
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(1)
Recent evidence suggests that certain forms of opioid-mediated hypoalgesia may depend on monosynaptic projections from the amygdala to nociceptive modulatory neurons in the midbrain. We recently demonstrated that the microinjection of morphine sulfat
Autor:
F J, Helmstetter, P S, Bellgowan
Publikováno v:
Behavioral neuroscience. 108(5)
The amygdala is known to be important for normal aversive Pavlovian learning in the rat. The relative contribution of the amygdala to the learning vs. performance of conditional fear with the GABAa agonist muscimol was assessed. Rats were prepared wi
Autor:
F J, Helmstetter, P S, Bellgowan
Publikováno v:
Behavioral neuroscience. 108(1)
Three experiments examined the antinociceptive response shown by rats during exposure to loud noise. Noise exposure resulted in a time-dependent elevation of radiant heat tail flick latency that varied as a function of stimulus intensity. Noise stres
Publikováno v:
Behavioral neuroscience. 103(3)
MR2266 (MR), an opioid antagonist that binds to kappa and mu receptors, was examined for its ability to influence the aversively motivated behaviors conditioned by electric shock and the drinking induced by water deprivation or the availability of a
Autor:
F J, Helmstetter, M S, Fanselow
Publikováno v:
Behavioral neuroscience. 101(5)
The ability of both naloxone and naltrexone to block conditional analgesia produced by shock associated contextual stimuli was determined using rats from three suppliers. Naltrexone (7 mg/kg) was equally effective in reversing analgesia on the formal
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 250(3)
When rats are returned to an environment in which they previously received electric shock they show a reduction in sensitivity to painful stimuli. This conditional fear-induced analgesia was measured using the formalin test. The octapeptide Cys2Tyr3O