Zobrazeno 1 - 10
of 21
pro vyhledávání: '"F. J. Giblin"'
Publikováno v:
Journal of glaucoma. 3(2)
The trabecular meshwork is continuously challenged by oxidants that are both present in the aqueous humor and generated within the tissue. In this study we have investigated the antioxidant properties of cultured calf trabecular meshwork cells and ev
Autor:
V N, Reddy, F J, Giblin, L R, Lin, L, Dang, N J, Unakar, D C, Musch, D L, Boyle, L J, Takemoto, Y S, Ho, T, Knoernschild, A, Juenemann, E, Lütjen-Drecoll
Publikováno v:
Investigative ophthalmologyvisual science. 42(13)
Previous in vitro studies with transgenic and gene-knockout mice have shown that lenses with elevated levels of glutathione peroxidase (GPX)-1 activity are able to resist the cytotoxic effect of H(2)O(2), compared with normal lenses and lenses from G
Publikováno v:
Investigative ophthalmologyvisual science. 41(10)
To measure lipid compositional and structural changes in lenses as a result of hyperbaric oxygen (HBO) treatment in vivo. HBO treatment in vivo has been shown to produce increased lens nuclear light scattering.Guinea pigs, approximately 650 days old
Publikováno v:
Investigative ophthalmologyvisual science. 39(2)
High levels of ascorbic acid are known to be present in the aqueous humor of many diurnal species, whereas nocturnal animals have low concentrations of the compound. The purpose of this study was to test the hypothesis that the high concentration of
Publikováno v:
Investigative ophthalmologyvisual science. 36(9)
In view of the antioxidant role of ascorbic acid and the glutathione redox cycle in the lens, the authors have studied the relationship of the cycle to reduction of the oxidized product of ascorbic acid, dehydroascorbic acid (DHA), in lens epithelium
Publikováno v:
Investigative ophthalmologyvisual science. 36(2)
To investigate the effect of hydrogen peroxide on the epithelial cells of cultured rabbit lenses.Lenses were cultured in minimum essential medium containing a single dose of 0.03, 0.1, or 0.2 mM H2O2. Three hours later the medium was replaced with pe
Publikováno v:
Investigative ophthalmologyvisual science. 33(7)
The polyol pathway was investigated in primary cultures of human retinal pigment epithelial (HRPE) cells and the results were compared with those in human lens epithelial (HLE) cells cultured under similar conditions. Significant levels of galactitol
Publikováno v:
Investigative ophthalmologyvisual science. 24(9)
The present study was designed to examine the possible role of calcium in the opacification of x-ray-induced cataract in rabbit. The results demonstrate that the concentration of calcium in x-rayed lenses, just prior to lens hydration (7.5 weeks post
Autor:
V N, Reddy, F J, Giblin
Publikováno v:
Ciba Foundation symposium. 106
The mammalian lens contains an unusually high concentration of glutathione (GSH), the highest level being in the epithelium. GSH is present largely in the reduced state. The high concentration of GSH in a normal lens and the decreased concentration i