Modeling the Dependence of Immunodominance on T Cell Dynamics in Prime-Boost Vaccines

Autor: Miguel A. Herrero, Cristina Fernandez-Arias, F. J. Acosta, Federica Bertocchini, Clemente F. Arias

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Mathematics
Volume 9
Issue 1
Mathematics, Vol 9, Iss 28, p 28 (2021)
Digital.CSIC. Repositorio Institucional del CSIC

The protection induced by vaccines against infectious diseases such as malaria, dengue or hepatitis relies on a the creation of immune memory by T cells, key components of the human immune system. The induction of a strong T cell response leading to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14b53b7bbf09d895b82aaab12c382ba
https://doi.org/10.3390/math9010028

Modeling the effect of boost timing in murine irradiated sporozoite prime-boost vaccines

Autor: Clemente F. Arias, F. J. Acosta, Min Zhang, Cristina Fernandez-Arias, Miguel A. Herrero, Moriya Tsuji

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 1, p e0190940 (2018)

Vaccination with radiation-attenuated sporozoites has been shown to induce CD8+ T cell-mediated protection against pre-erythrocytic stages of malaria. Empirical evidence suggests that successive inoculations often improve the efficacy of this type of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d931c7b723643dea0e7f909db16816d9
http://europepmc.org/articles/PMC5766151

A mathematical model for a T cell fate decision algorithm during immune response

Autor: Clemente F. Arias, Cristina Fernandez-Arias, Miguel A. Herrero, F. J. Acosta

Publikováno v: Journal of Theoretical Biology. 349:109-120

We formulate and analyze an algorithm of cell fate decision that describes the way in which division vs. apoptosis choices are made by individual T cells during an infection. Such model involves a minimal number of known biochemical mechanisms: it ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a8f5c0787a3ccd10728c589948c21f
https://doi.org/10.1016/j.jtbi.2014.01.039

Intense reactions of recruitment facing unusual stimuli in Messor barbarus (L.) (Hymenoptera, Formicidae)

Autor: Francisco Zamora López, J. M. Serrano, F. J. Acosta

Publikováno v: Deutsche Entomologische Zeitschrift. 39:135-142

The foraging strategy of the granivore species Messor barbarus implies the development of trails for the gathering of food. In a studied population in this species, the colonies react with strong recruitment and foraging activity to unusual objects �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efc205049e18632bc6a067de04eafe27
https://doi.org/10.1002/mmnd.19920390119

Hierarchical pre-dispersal fitness assessment in a Mediterranean shrub plant

Autor: Juan A. Delgado, F. J. Acosta, Francisco Zamora López, J. M. Serrano, Sara G. Fungairiño

Publikováno v: Perspectives in Plant Ecology, Evolution and Systematics. 9:29-35

Under the concept of modularity, it is possible to recognise how seed production, as well as any other process affecting it, are hierarchically structured within fruits, within individual plants and within populations. In this work, we analysed the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80ed4366f1a42550b513a6773800789d
https://doi.org/10.1016/j.ppees.2007.07.002