Výsledky vyhledávání - "F. I. Carroll"

Akademický článek

Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse.

Autor: M D Raleigh, S J Peterson, M Laudenbach, F Baruffaldi, F I Carroll, S D Comer, H A Navarro, T L Langston, S P Runyon, S Winston, M Pravetoni, P R Pentel

Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0184876 (2017)

Among vaccines aimed at treating substance use disorders, those targeting opioids present several unique medication development challenges. 1) Opioid overdose is a common complication of abuse, so it is desirable for an opioid vaccine to block the to

Externí odkaz: https://doaj.org/article/3b2e7ab5a7434204b22b8fab42f5d495

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Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice

Autor: Olivier George, Robert E. Vann, Louis S. Harris, Jenny L. Wiley, F. I. Carroll, Marc R. Azar, D.M. Walentiny, M. I. Damaj, George F. Koob, K.M. Tobey

Publikováno v: Psychopharmacology. 223:159-168

Alleviating addiction to tobacco products could prevent millions of deaths. Investigating novel compounds selectively targeting α4β2 nAChRs hypothesized to have a key role in the rewarding effects of nicotine may be a useful approach for future tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755a3a9bae1624b4c8ee0098fb37a164
https://doi.org/10.1007/s00213-012-2703-3

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Neutral antagonist activity of naltrexone and 6β-naltrexol in naïve and opioid-dependent C6 cells expressing a µ-opioid receptor

Autor: John R. Traynor, Faye A. Bradbury, Mary F. Divin, F. I. Carroll

Publikováno v: British Journal of Pharmacology. 156:1044-1053

Background and purpose Adenylyl cyclase sensitization occurs on chronic agonist activation of mu-opioid receptors and is manifested by an increase in cAMP levels (overshoot) on challenge with antagonist. It has been proposed that a long lasting const

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f7030e8a73552ae5d6538e9ae354d8a
https://doi.org/10.1111/j.1476-5381.2008.00035.x

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Abnormal error processing in depressive states: a translational examination in humans and rats

Autor: Josephine Lee, Rachel J. Donahue, D Foti, Courtney Beard, Daniel G. Dillon, A. Van't Veer, Kean J. Hsu, F I Carroll, Thröstur Björgvinsson, Diego A. Pizzagalli, Elyssa M. Barrick, Chelsea J Webber, William A. Carlezon

Publikováno v: Translational Psychiatry

Depression has been associated with poor performance following errors, but the clinical implications, response to treatment and neurobiological mechanisms of this post-error behavioral adjustment abnormality remain unclear. To fill this gap in knowle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0e36193cf2396f01266de330967688
https://pubmed.ncbi.nlm.nih.gov/25966364

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Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist

Autor: Anna M.W. Taylor, Christopher J. Evans, Kabirullah Lutfy, F. I. Carroll, Amynah A. Pradhan, Kristofer W. Roberts, Wendy Walwyn, Catherine M. Cahill, H A Akbari

Publikováno v: Taylor, AMW; Roberts, KW; Pradhan, AA; Akbari, HA; Walwyn, W; Lutfy, K; et al.(2015). Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist. British Journal of Pharmacology, 172(2), 691-703. doi: 10.1111/bph.12810. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0t14s65k
British journal of pharmacology, vol 172, iss 2
British Journal of Pharmacology, vol 172, iss 2
British Journal of Pharmacology
Taylor, AMW; Roberts, KW; Pradhan, AAA; Akbari, HA; Walwyn, WM; Lutfy, K; et al.(2014). Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist. British Journal of Pharmacology. doi: 10.1111/bph.12810. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1qq8412x

Background and Purpose The opioid receptor family comprises four structurally homologous but functionally distinct sub-groups, the μ (MOP), δ (DOP), κ (KOP) and nociceptin (NOP) receptors. As most opioid agonists are selective but not specific, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994ae2fb64d5c8b5dca7c50718a759e6
http://www.escholarship.org/uc/item/0t14s65k

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Discovery of an Opioid κ Receptor Selective Pure Antagonist from a Library of N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphans

Autor: Jim A. Thomas, Robert N. Atkinson, D. M. Zimmerman, Noelle Vinson, Richard B. Rothman, Christina M. Dersch, Kenneth M. Gigstad, Nivedita Namdev, Scott E. Fix, Jason P. Burgess, Heng Xu, F. I. Carroll, S. W. Mascarella, B. E. Cantrell

Publikováno v: Journal of Medicinal Chemistry. 45:3524-3530

A library of compounds biased toward opioid receptor antagonist activity was prepared by incorporating N-phenylpropyl-4beta-methyl-5-(3-hydroxyphenyl)morphans as the core scaffold using simultaneous solution phase synthetic methodology. From this lib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cf41f988f4d576a71855a6c19e3670
https://doi.org/10.1021/jm020084h

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Examination of the metabolite hydroxybupropion in the reinforcing and aversive stimulus effects of nicotine in rats

Autor: Emma M. Malcolm, M. I. Damaj, Mohammed Shoaib, F. I. Carroll, Bruce E. Blough

Publikováno v: Psychopharmacology. 232(15)

Preclinical studies with bupropion in rodent models of nicotine dependence have generated equivocal findings with regard to translating the clinical efficacy of the antidepressant as a smoking cessation agent.Given that rats are poor metabolizers of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f13f19eb28efdd446f59a5aae047992
https://pubmed.ncbi.nlm.nih.gov/25761841

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Continuous infusion of selective dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor activity

Autor: Paul M. Kunko, Sari Izenwasser, Dawn French, F I Carroll

Publikováno v: Behavioural Brain Research. 99:201-208

Chronic continuous cocaine treatment produces a unique pattern of locomotor activation over time. An initial, progressive increase in locomotion is indicative of sensitization. Unlike intermittent cocaine, this increase is subsequently reversed durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081c95e3c1823a339ce7704126b6291d
https://doi.org/10.1016/s0166-4328(98)00104-1

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Ohmefentanyl and Its Stereoisomers: Chemistry and Pharmacology

Autor: G. A. Brine, F. I. Carroll, T. M. Richardson-Leibert, H. Xu, R. B. Rothman

Publikováno v: Current Medicinal Chemistry. 4:247-270

Ohmefentanyl., or β-hydroxy-3-methylfentanyl, is an unique member of the 4-anilidopiperidine class of opiates. This review summarizes both the initial studies on mixtures of ohmefentanyl stereoisomers and some more recent studies on the eight indivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8991d11365d2ba5d44a48689c5c8907
https://doi.org/10.2174/0929867304666220313115017

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Ibogaine block of the NMDA receptor: In vitro and in vivo studies

Autor: K Chen, Tushar G. Kokate, Michael A. Rogawski, Sean D. Donevan, F I Carroll

Publikováno v: Neuropharmacology. 35:423-431

Ibogaine is an hallucinogenic indole alkaloid claimed to have anti-addictive properties. Although its mechanism of action is unknown, binding studies have indicated that the drug may interact with N-methyl-D-aspartate (NMDA) receptors. We further inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc37d946342ba20ca2018f2bad8cb2c7
https://doi.org/10.1016/0028-3908(96)84107-4

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