Zobrazeno 1 - 10
of 585
pro vyhledávání: '"F. Hickey"'
Autor:
Bhavana Nayer, Jean L. Tan, Yasmin K. Alshoubaki, Yen-Zhen Lu, Julien M. D. Legrand, Sinnee Lau, Nan Hu, Anthony J. Park, Xiao-Nong Wang, Daniela Amann-Zalcenstein, Peter F. Hickey, Trevor Wilson, Gisela A. Kuhn, Ralph Müller, Ajithkumar Vasanthakumar, Shizuo Akira, Mikaël M. Martino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Regulatory T cells (Tregs) are crucial immune cells for tissue repair and regeneration. However, their potential as a cell-based regenerative therapy is not yet fully understood. Here, we show that local delivery of exogenous Tregs into inju
Externí odkaz:
https://doaj.org/article/f42f79ea96ac4536ad48ec4b75f69576
Autor:
Yasmin K. Alshoubaki, Bhavana Nayer, Yen-Zhen Lu, Ekaterina Salimova, Sin Nee Lau, Jean L. Tan, Daniela Amann-Zalcenstein, Peter F. Hickey, Gonzalo del Monte-Nieto, Ajithkumar Vasanthakumar, Mikaël M. Martino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Regulatory T cells (Tregs) are key immune regulators that have shown promise in enhancing cardiac repair post-MI, although the mechanisms remain elusive. Here, we show that rapidly increasing Treg number in the circulation post-MI via system
Externí odkaz:
https://doaj.org/article/a905ba98718746ceb7e2cdf602aafd25
Autor:
Junghoon Lee, Adrianna L. De La Torre, Felix L. Rawlinson, Dylan B. Ness, Lionel D. Lewis, William F. Hickey, Catherine C. Y. Chang, Ta Yuan Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9151 (2024)
Cholesterol homeostasis is pivotal for cellular function. Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1), also abbreviated as SOAT1, is an enzyme responsible for catalyzing the storage of excess cholesterol to cholesteryl esters. ACAT1 is an e
Externí odkaz:
https://doaj.org/article/0cdf9d54a6cb449a8a13d8b0b47dd0ae
Autor:
Yue You, Xueyi Dong, Yong Kiat Wee, Mhairi J. Maxwell, Monther Alhamdoosh, Gordon K. Smyth, Peter F. Hickey, Matthew E. Ritchie, Charity W. Law
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Group heteroscedasticity is commonly observed in pseudo-bulk single-cell RNA-seq datasets and its presence can hamper the detection of differentially expressed genes. Since most bulk RNA-seq methods assume equal group variances, we introduce
Externí odkaz:
https://doaj.org/article/d10773884bdb4c46881828200216a0c4
BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation
Autor:
Andrew Keniry, Natasha Jansz, Linden J. Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M. Nefzger, Peter F. Hickey, Quentin Gouil, Joy Liu, Kelsey A. Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A. Kinkel, Phillippa C. Taberlay, Tracy Willson, Miha Pakusch, Matthew E. Ritchie, Douglas J. Hilton, Jose M. Polo, Marnie E. Blewitt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Female embryonic stem cells (ESCs) are the ideal model to study X chromosome inactivation (XCI) establishment; however, these cells are challenging to keep in culture. Here the authors create fluorescent ‘Xmas’ reporter mice as a renewable source
Externí odkaz:
https://doaj.org/article/55d8f97f36464af78639b6d7c2a5c371
Autor:
Adrianna L. De La Torre, Thao N. Huynh, Catherine C. Y. Chang, Darcy B. Pooler, Dylan B. Ness, Lionel D. Lewis, Sanjana Pannem, Yichen Feng, Kimberley S. Samkoe, William F. Hickey, Ta Yuan Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11013 (2023)
Cholesterol is essential for cellular function and is stored as cholesteryl esters (CEs). CEs biosynthesis is catalyzed by the enzymes acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), with ACAT1 being the primary isoenzyme in most cell
Externí odkaz:
https://doaj.org/article/68bc0686d0ab44e1a0995babc0169b8d
Autor:
Yue You, Luyi Tian, Shian Su, Xueyi Dong, Jafar S. Jabbari, Peter F. Hickey, Matthew E. Ritchie
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-32 (2021)
Abstract Background Single-cell RNA-sequencing (scRNA-seq) technologies and associated analysis methods have rapidly developed in recent years. This includes preprocessing methods, which assign sequencing reads to genes to create count matrices for d
Externí odkaz:
https://doaj.org/article/52b16953cfe04fc5a8828e3325d5735b
Autor:
Yue You, Xueyi Dong, Yong Kiat Wee, Mhairi J. Maxwell, Monther Alhamdoosh, Gordon K. Smyth, Peter F. Hickey, Matthew E. Ritchie, Charity W. Law
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/069db538e8c34bdfb20f76f929315fd0
Autor:
Lindsay F. Rizzardi, Peter F. Hickey, Adrian Idrizi, Rakel Tryggvadóttir, Colin M. Callahan, Kimberly E. Stephens, Sean D. Taverna, Hao Zhang, Sinan Ramazanoglu, GTEx Consortium, Kasper D. Hansen, Andrew P. Feinberg
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background DNA methylation dynamics in the brain are associated with normal development and neuropsychiatric disease and differ across functionally distinct brain regions. Previous studies of genome-wide methylation differences among human b
Externí odkaz:
https://doaj.org/article/fff90ca74fe2430eb0baacf7ea4ca109
Autor:
Faith L. Anderson, Katharine M. von Herrmann, Angeline S. Andrew, Yuliya I. Kuras, Alison L. Young, Clemens R. Scherzer, William F. Hickey, Stephen L. Lee, Matthew C. Havrda
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms and loss of dopaminergic neurons of the substantia nigra. Inflammation and cell death are recognized aspects of PD suggesting that strat
Externí odkaz:
https://doaj.org/article/892f9bbb0b7f49018d57cd57aa5de398