Zobrazeno 1 - 10
of 13
pro vyhledávání: '"F. Heeg"'
POS-430 CRISPR/CAS9 TARGETING TTTC30A MIMICS CILIARY CHONDRODYSPLASIA WITH POLYCYSTIC KIDNEY DISEASE
Autor:
Maike Getwan, Konstantin Deutsch, Ekkehart Lausch, Pascal Schlosser, R. Diehl, F. Heeg, Anna Köttgen, Friedhelm Hildebrandt, W. Song, Sophie Schroda, Lienkamp Ss, Anselm Hoppmann, K. Grand
Publikováno v:
Kidney International Reports, Vol 6, Iss 4, Pp S187-(2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995ce281c3a939787c380a1e56aa1532
http://www.sciencedirect.com/science/article/pii/S2468024921005994
http://www.sciencedirect.com/science/article/pii/S2468024921005994
Autor:
Friedhelm Hildebrandt, Anselm Hoppmann, W. Song, Ekkehart Lausch, A. Koettgen, Konstantin Deutsch, Soeren S. Lienkamp, R. Diehl, F. Heeg, Maike Getwan, Pascal Schlosser, Sophie Schroda, K. Grand
Skeletal ciliopathies (e.g. Jeune syndrome, short rib polydactyly syndrome, Sensenbrenner syndrome) are frequently associated with cystic kidney disease and other organ manifestations, but a common molecular mechanism has remained elusive.We establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3d4edc349b9af2ae9c2b97153d8904d
https://doi.org/10.1101/2020.11.27.400994
https://doi.org/10.1101/2020.11.27.400994
Publikováno v:
Journal of Pharmaceutical Sciences. 84:152-157
The pharmacokinetics of enoximone and its sulfoxide metabolite were investigated in healthy male volunteers after various intravenous administrations: a bolus single dose, a continuous infusion, and bolus multiple doses of enoximone. The overall phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fca906d1081e33d0dc6d15e28810f53
https://doi.org/10.1002/jps.2600840206
https://doi.org/10.1002/jps.2600840206
Akademický článek
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Akademický článek
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Akademický článek
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Publikováno v:
Journal of Pharmaceutical Sciences. 73:1758-1763
The bioavailability and pharmacokinetic behavior of 10 mg/kg of [ 14 C]probucol in an oil-water emulsion was determined after oral and intravenous administration to rats. The bioavailability of the oral formulation was ~6%. For the first 12-h interva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bc66f6bd9f06f8e8ee9953ef75514c
https://doi.org/10.1002/jps.2600731225
https://doi.org/10.1002/jps.2600731225
Publikováno v:
Journal of Pharmaceutical Sciences. 66:96-99
Meglumine labeled with carbon‐14 was administered orally as 14 C‐meglumine salicylate to rats and dogs to study its distribution and excretion. The compound was incompletely absorbed; that which was absorbed was rapidly excreted in the urine. Pea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bf80fe2b75f27842517791a6ee5457
https://doi.org/10.1002/jps.2600660124
https://doi.org/10.1002/jps.2600660124
Publikováno v:
Journal of Labelled Compounds. 7:165-169
14C-uniformly ring labeled 3,3′,5,5′-tetra-tert-butyldiphenoquinone was synthesized from 2,6-di-tert-butylphenol. Chemical purity was established by mixed melting point, thin-layer and gas-liquid chromatography. Radiochemical purity was determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be821124cc7738d797adfe49ddb121da
https://doi.org/10.1002/jlcr.2590070211
https://doi.org/10.1002/jlcr.2590070211
Autor:
J F, Heeg, H, Tachizawa
Publikováno v:
La Nouvelle presse medicale. 9(40)
Following administration of a single oral dose of 3 g probucol to healthy volunteers, mean peak plasma concentrations of 3.9 microgram/ml were observed at 24 hours. Successive blood levels measurements showed diphasic elimination, with half-lives of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dafb52db7522c49c1742b1905d723fb1
https://pubmed.ncbi.nlm.nih.gov/7443437
https://pubmed.ncbi.nlm.nih.gov/7443437