Zobrazeno 1 - 10
of 13
pro vyhledávání: '"F. H. Hausheer"'
Publikováno v:
Journal of Molecular Biology. 303:679-692
Tubulin, the major structural component of the microtubules, participates actively in mitotic spindle formation and chromosomal organization during cell division. Tubulin is the major target for a variety of anti-mitotic drugs. Some of the drugs, suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::178906aa14f9eb757563615938829ebf
https://doi.org/10.1006/jmbi.2000.4156
https://doi.org/10.1006/jmbi.2000.4156
Autor:
M, Maliepaard, M A, van Gastelen, A, Tohgo, F H, Hausheer, R C, van Waardenburg, L A, de Jong, D, Pluim, J H, Beijnen, J H, Schellens
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(4)
This study was aimed at characterizing the role of BCRP/MXR/ABCP (BCRP) in resistance of the human ovarian tumor cell lines T8 and MX3 to camptothecins more extensively and investigating whether resistance can be reversed by inhibiting BCRP by GF1209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69a01d6f5c500325798340dae24df5c4
https://pubmed.ncbi.nlm.nih.gov/11309344
https://pubmed.ncbi.nlm.nih.gov/11309344
Publikováno v:
Journal of molecular biology. 303(5)
Tubulin, the major structural component of the microtubules, participates actively in mitotic spindle formation and chromosomal organization during cell division. Tubulin is the major target for a variety of anti-mitotic drugs. Some of the drugs, suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a3c7b379bb55b99aec4ed1299b2b0c8
https://pubmed.ncbi.nlm.nih.gov/11061968
https://pubmed.ncbi.nlm.nih.gov/11061968
Publikováno v:
International journal of cancer. 88(2)
BNP1350, 7-[(2-trimethylsilyl)ethyl]-20(S)-camptothecin, is a novel semi-synthetic, highly lipophilic, silicon-containing camptothecin and an inhibitor of topoisomerase I. It has been supercomputer engineered for superior oral bioavailability, superi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::514ab1cd3941fc613cde8bc36dad8d80
https://pubmed.ncbi.nlm.nih.gov/11004678
https://pubmed.ncbi.nlm.nih.gov/11004678
Autor:
F H, Hausheer, P, Kanter, S, Cao, K, Haridas, P, Seetharamulu, D, Reddy, P, Petluru, M, Zhao, D, Murali, J D, Saxe, S, Yao, N, Martinez, A, Zukowski, Y M, Rustum
Publikováno v:
Seminars in oncology. 25(5)
Platinum-type drugs have proven to be valuable in the treatment of a variety of solid tumors, beginning with the commercial approval of cisplatin 18 years ago. There are several clinically important toxicities commonly associated with the administrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7238cf26f2d7b60ac5c70ad42ba459e9
https://pubmed.ncbi.nlm.nih.gov/9783598
https://pubmed.ncbi.nlm.nih.gov/9783598
Publikováno v:
Cancer research. 58(17)
We report the first experimental observation that a clinically important camptothecin [CPT; topotecan (TPT), a water-soluble CPT] binds directly and noncovalently to double-stranded DNA and single-stranded DNA structures in the absence of topoisomera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34b50cd986bb30772bac6e7160ba6f81
https://pubmed.ncbi.nlm.nih.gov/9731484
https://pubmed.ncbi.nlm.nih.gov/9731484
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(4)
As part of a continuing program aimed at developing nonpolyglutamylatable inhibitors of dihydrofolate reductase that are less toxic and more specific in their action, we herein report the therapeutic efficacy and toxicity of gamma-methylene-10-deazaa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::238c21a1751ea43f293dd98f795950e4
https://pubmed.ncbi.nlm.nih.gov/9816221
https://pubmed.ncbi.nlm.nih.gov/9816221
Publikováno v:
Anti-cancer drug design. 5(2)
Molecular dynamics simulations of oligonucleoside methylphosphonates (MP) and naturally occurring oligodeoxynucleotides (ODN) as the third strand to double-stranded (ds) DNA targets predict that the third strand with MP backbone is more favorable to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40c1cdd3522fc3614ce8bc5fb91ead4b
https://pubmed.ncbi.nlm.nih.gov/2357262
https://pubmed.ncbi.nlm.nih.gov/2357262
Publikováno v:
Journal of Molecular Graphics. 7:160-164
Ray tracing is an elegant and powerful technique for creating computer-generated images. The wide variety of geometric primitives and realistic effects, such as reflections, transparency, and shadows, make it one of the most popular rendering methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfda445afec3703c71e0a6a9f25127e
https://doi.org/10.1016/0263-7855(89)80020-7
https://doi.org/10.1016/0263-7855(89)80020-7
Autor:
T. C. Palmer, F. H. Hausheer
Publikováno v:
Journal of Molecular Graphics. 6:149-154
A new algorithm for rendering CPK images of molecules is presented. The algorithm is based on the observation that (given certain assumptions) the appearance of a sphere representing an atom is independent of the atom's position or orientation. For e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44d975215745845399b8bd03c1beacb8
https://doi.org/10.1016/0263-7855(88)80067-5
https://doi.org/10.1016/0263-7855(88)80067-5