Zobrazeno 1 - 5
of 5
pro vyhledávání: '"F. H. Guedes-da-Silva"'
Autor:
Galina I. Lepesheva, Marcos Meuser Batista, Constança Britto, Beatriz Philot Pavão, Denise da Gama Jaen Batista, Fernando Villalta, Leticia Rocha Quintino Souza, Cristiane França da Silva, Girish Rachakonda, Otacilio C. Moreira, F. H. Guedes-da-Silva, Maria de Nazaré Correia Soeiro
Publikováno v:
ACS Infectious Diseases. 5:365-371
Up to now, no vaccines are available for Chagas disease, and the current therapy is largely unsatisfactory. Novel imidazole-based scaffolds of protozoan sterol 14α-demethylase (CYP51) inhibitors have demonstrated potent antiparasitic activity with n
Autor:
Cristiane França da Silva, Vicente J. Arán, Marcos Meuser Batista, Maria de Nazaré Correia Soeiro, Mariane Vasconcelos, Alicia Gómez-Barrio, Cristina Fonseca-Berzal, José Antonio Escario, F. H. Guedes-da-Silva, Kelly Cristina Demarque
Publikováno v:
Proceedings, Vol 1, Iss 6, p 655 (2017)
Benznidazole and nifurtimox, the currently available drugs for the specific treatment of Chagas disease, show limited effectiveness and high toxicity that prompt the identification of therapeutic alternatives. [...]
Autor:
Galina I. Lepesheva, M. M. Batista, Beatriz Philot Pavão, J. S. De Araújo, F. H. Guedes-da-Silva, Constança Britto, Otacilio C. Moreira, Maria de Nazaré Correia Soeiro, Kelly Cristina Demarque, D. G. J. Batista, M. R. Simões-Silva, C. F. Da Silva
Chagas disease is a life-threatening infection caused by a variety of genetically diverse strains of the protozoan parasite Trypanosoma cruzi . The current treatment (benznidazole and nifurtimox) is unsatisfactory, and potential alternatives include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3de3b382396845a939defab848fc76
https://europepmc.org/articles/PMC5365685/
https://europepmc.org/articles/PMC5365685/
Autor:
Donald A. Patrick, R R Tidwell, Maria de Nazaré Correia Soeiro, Otacilio C. Moreira, C. F. Da Silva, P. B. Da Silva, Kelly Cristina Demarque, Svetlana M. Bakunova, Constança Britto, Stanislav A. Bakunov, T. O. Fulco, Julianna Siciliano de Araújo, F. H. Guedes-da-Silva, Gilkethyla Mexlayne de Oliveira, D. G. J. Batista, M. B. Meuser
Arylimidamides (AIAs) have been shown to have considerable biological activity against intracellular pathogens, including Trypanosoma cruzi , which causes Chagas disease. In the present study, the activities of 12 novel bis-AIAs and 2 mono-AIAs again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9931d7933fdd07aea27acf8c429ef9b4
https://europepmc.org/articles/PMC4808220/
https://europepmc.org/articles/PMC4808220/
Autor:
Galina I. Lepesheva, C. F. Da Silva, M. B. Meuser, M. R. Simões-Silva, Maria de Nazaré Correia Soeiro, J. S. De Araújo, F. H. Guedes-da-Silva, Otacilio C. Moreira, Constança Britto, D. G. J. Batista, C. G. Ferreira
The lack of translation between preclinical assays and clinical trials for novel therapies for Chagas disease (CD) indicates a need for more feasible and standardized protocols and experimental models. Here, we investigated the effects of treatment w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304c34c8c27140cfeabfc1708205b591
https://europepmc.org/articles/PMC4649169/
https://europepmc.org/articles/PMC4649169/