Zobrazeno 1 - 10
of 211
pro vyhledávání: '"F. Greber"'
Autor:
Katarina Wendy Schmidt, Charlotte Montespan, Danielle Thompson, Miriam S. Lucas, Laure-Anne Ligeon, Harald Wodrich, Alexander S. Hahn, Urs F. Greber, Christian Münz
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 115019- (2024)
Summary: Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesvirus. Autophagy during KSHV entry has remained unexplored. We show that LC3 lipidation as a hallmark of autophagy is induced shortly after KSHV entry. LC3 co-localizes wi
Externí odkaz:
https://doaj.org/article/5e3e4b63b6604084a7707d800fee0cfc
Autor:
Ravi Ojha, Anmin Jiang, Elina Mäntylä, Tania Quirin, Naphak Modhira, Robert Witte, Arnaud Gaudin, Lisa De Zanetti, Rachel Sarah Gormal, Maija Vihinen-Ranta, Jason Mercer, Maarit Suomalainen, Urs F Greber, Yohei Yamauchi, Pierre-Yves Lozach, Ari Helenius, Olli Vapalahti, Paul Young, Daniel Watterson, Frédéric A Meunier, Merja Joensuu, Giuseppe Balistreri
Publikováno v:
PLoS Pathogens, Vol 20, Iss 11, p e1012690 (2024)
Mammalian receptor-mediated endocytosis (RME) often involves at least one of three isoforms of the large GTPase dynamin (Dyn). Dyn pinches-off vesicles at the plasma membrane and mediates uptake of many viruses, although some viruses directly penetra
Externí odkaz:
https://doaj.org/article/7d80452f88364b7eabad53af110c4b45
Publikováno v:
mSphere, Vol 9, Iss 10 (2024)
ABSTRACT Viruses display large variability across all stages of their life cycle, including entry, gene expression, replication, assembly, and egress. We previously reported that the immediate early adenovirus (AdV) E1A transcripts accumulate in huma
Externí odkaz:
https://doaj.org/article/118e56feac574cf6bd0841bbcfd4d747
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Virus infectivity is traditionally determined by endpoint titration in cell cultures, and requires complex processing steps and human annotation. Here we developed an artificial intelligence (AI)-powered automated framework for ready detecti
Externí odkaz:
https://doaj.org/article/6639d7438820480b8a90f57d44f97b75
Autor:
Dominik Olszewski, Fanny Georgi, Luca Murer, Vardan Andriasyan, Fabien Kuttler, Anthony Petkidis, Robert Witte, Artur Yakimovich, Lucy Fischer, Alina Rozanova, Yohei Yamauchi, Gerardo Turcatti, Urs F. Greber
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-12 (2022)
Measurement(s) transmission of virus • drug toxicity Technology Type(s) fluorescence microscopy Factor Type(s) virus genotype • cell line • incubation temperature • number of cells seeded/ seeding density • inoculation time • virus input
Externí odkaz:
https://doaj.org/article/7c70c488f62c453cb039023f3cc4d369
Autor:
Dominik Brücher, Nicole Kirchhammer, Sheena N. Smith, Jatina Schumacher, Nina Schumacher, Jonas Kolibius, Patrick C. Freitag, Markus Schmid, Fabian Weiss, Corina Keller, Melanie Grove, Urs F. Greber, Alfred Zippelius, Andreas Plückthun
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 572-586 (2021)
Adenovirus-mediated combination gene therapies have shown promising results in vaccination or treating malignant and genetic diseases. Nevertheless, an efficient system for the rapid assembly and incorporation of therapeutic genes into high-capacity
Externí odkaz:
https://doaj.org/article/73cbb7e72f084e14b563c3eee31cae0b
Autor:
Vibhu Prasad, Maarit Suomalainen, Yllza Jasiqi, Silvio Hemmi, Patrick Hearing, Louise Hosie, Hans-Gerhard Burgert, Urs F. Greber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Adenovirus (AdV) can cause persistent infections, but underlying mechanisms are poorly understood. Here, Prasad et al. show that the AdV glycoprotein E3-19K activates the unfolded protein response sensor IRE1α, and that this triggers a feedforward l
Externí odkaz:
https://doaj.org/article/0c377f65c8de48bc8b345b4796d48f32
Autor:
Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer, Burkhard Kleuser, Eduard B. Babiychuk, Beate Sodeik, Jürgen Seibel, Urs F. Greber, Philipp A. Lang, Erich Gulbins, Karl S. Lang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.
Externí odkaz:
https://doaj.org/article/ce87beeac86246829e4b47c4ed971f39
Autor:
Romain Volle, Luca Murer, Anthony Petkidis, Vardan Andriasyan, Alessandro Savi, Cornelia Bircher, Nicole Meili, Lucy Fischer, Daniela Policarpo Sequeira, Daniela Katharina Mark, Alfonso Gomez-Gonzalez, Urs F. Greber
Publikováno v:
Current Research in Microbial Sciences, Vol 3, Iss , Pp 100158- (2022)
Sublineages of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) Omicron variants continue to amass mutations in the spike (S) glycoprotein, which leads to immune evasion and rapid spread of the virus across the human population. Here we d
Externí odkaz:
https://doaj.org/article/d8ad84f357884e6f9c37c23057a20df8
Autor:
Manuela Bieri, Rodinde Hendrickx, Michael Bauer, Bin Yu, Tania Jetzer, Birgit Dreier, Peer R E Mittl, Jens Sobek, Andreas Plückthun, Urs F Greber, Silvio Hemmi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010083 (2021)
Mammalian adenoviruses (AdVs) comprise more than ~350 types including over 100 human (HAdVs) and just three mouse AdVs (MAdVs). While most HAdVs initiate infection by high affinity/avidity binding of their fiber knob (FK) protein to either coxsackiev
Externí odkaz:
https://doaj.org/article/5d5d9edb15f14f5a912f7cdb9031e592