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Akademický článek

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

Autor: M. J. Vazquez, C. A. Toro, J. M. Castellano, F. Ruiz-Pino, J. Roa, D. Beiroa, V. Heras, I. Velasco, C. Dieguez, L. Pinilla, F. Gaytan, R. Nogueiras, M. A. Bosch, O. K. Rønnekleiv, A. Lomniczi, S. R. Ojeda, M. Tena-Sempere

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

The onset of mammalian puberty is sensitive to metabolic changes and nutritional status, but the mechanisms underlying this phenomenon are poorly understood. Here the authors show that the epigenetic regulator of transcription, SIRT1, mediates the ef

Externí odkaz: https://doaj.org/article/71c4e883f27d431aa22490145fc7c289

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Akademický článek

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Allogeneic Hematopoietic Stem Cell Transplant in a Pediatric Patient with Invasive Fungal Infections: Challenges and Indications

Autor: Rodolfo Norberto Jiménez-Juárez, Martha J. Aviles-Robles, F. Gaytan, I. Castorena, K. Ojeda-Diesbarroso

Publikováno v: Current Fungal Infection Reports. 15:8-16

Prior invasive fungal infection (IFI) in children with malignancies was considered a contraindication for hematopoietic stem cell transplant (HSCT). This review summarizes the current evidence in safety of allogeneic HSCT with prior IFI in children.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0870c4d2af780bfe3728ec69f8e23bf7
https://doi.org/10.1007/s12281-021-00411-z

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Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling

Autor: Rafael Pineda, David Garcia-Galiano, María Jesús Vázquez, Patricia Seoane-Collazo, Heras, Noelia Martínez-Sánchez, Alexia Barroso, Francisco Ruiz-Pino, Juan M. Castellano, Manuel Tena-Sempere, T. Ilhan, C. Dieguez, Matti Poutanen, Leonor Pinilla, F Gaytan, Juan Carlos Roa, Miguel López, S. Leon, anfredi-Lozano M

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 115(45):E10758-E10767

Conditions of metabolic distress, from malnutrition to obesity, impact, via as yet ill-defined mechanisms, the timing of puberty, whose alterations can hamper later cardiometabolic health and even life expectancy. AMP-activated protein kinase (AMPK),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5860a10f9e50e5dfce37f53c298b9674
https://doi.org/10.1073/pnas.1802053115

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Akademický článek

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Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome

Autor: S Leon, L Pinilla, F Gaytan, A Romero-Ruiz, M J Vazquez, Bernadette Mannaerts, M A Sanchez-Garrido, M. van Duin, M Manfredi-Lozano, Karolina Skorupskaite, S Qi, E Torres, Trudy A Kohout, Manuel Tena-Sempere, C Perdices-Lopez, María S. Avendaño, Richard A. Anderson, C Lopez-Rodriguez

Publikováno v: Human Reproduction (Oxford, England)
Romero-Ruiz, A, Skorupskaite, K, Gaytan, F, Torres, E, Perdices-Lopez, C, Mannaerts, B M, Qi, S, Leon, S, Manfredi-Lozano, M, Lopez-Rodriguez, C, Avendano, M S, Vasquez, M J, Pinilla, L, van Duin, M, Kohout, T A, Anderson, R & Tena-Sempere, M 2019, ' Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome ', Human Reproduction . https://doi.org/10.1093/humrep/dez205

STUDY QUESTION Can kisspeptin treatment induce gonadotrophin responses and ovulation in preclinical models and anovulatory women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER Kisspeptin administration in some anovulatory preclinical models an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1828702a26d1e45081dd0a304a1f4bde
https://pubmed.ncbi.nlm.nih.gov/31820802

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