Zobrazeno 1 - 10 of 137 pro vyhledávání: '"F. Friedlos"'
1
Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase
Autor: S Court, Marilyn Ford, William A. Denny, C Springer, F. Friedlos
Publikováno v: Gene Therapy. 5:105-112
Clones of human colon carcinoma (WiDr), ovarian carcinoma (SK-OV-3), and Chinese hamster V79 cells expressing the nitroreductase enzyme (NR) from E. coli B were 52-, 225- and 177-fold respectively more sensitive to a 24-h incubation with the prodrug
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252dfc83ae51db6c5df25e0b0c23c74f
https://doi.org/10.1038/sj.gt.3300569
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2
Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT)
Autor: I, Niculescu-Duvaz, F, Friedlos, D, Niculescu-Duvaz, L, Davies, C J, Springer
Publikováno v: Anti-cancer drug design. 14(6)
Antibody- and gene-directed enzyme prodrug therapy are two-step targeting strategies designed to improve the selectivity of antitumour agents. The approaches are based on the activation of specially designed prodrugs by antibody-enzyme conjugates tar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de2fd75ae312bda859b13b40f27443e9
https://pubmed.ncbi.nlm.nih.gov/10834273
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3
Sensitisation of Human Ovarian Cancer Cells to Killing by the Prodrug CB1954 Following Retroviral or Adenoviral Transfer of the E. coli Nitroreductase Gene
Autor: S. J. Weedon, David J. Kerr, Peter F. Searle, Caroline J. Springer, Lawrence S. Young, Iain A. McNeish, Moira G. Gilligan, F. Friedlos, M. J. Ford
Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781461374442
The enzyme nitroreductase from E. coli can reduce the relatively non-toxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) to the 2- or 4-hydroxylamino derivatives; the latter is a potent cytotoxic agent, which following further non-enzymatic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::842bb9d2c2544519c87f9a4862471891
https://doi.org/10.1007/978-1-4615-5357-1_17
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4
Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes
Autor: S, Chen, R, Knox, A D, Lewis, F, Friedlos, P, Workman, P S, Deng, M, Fung, D, Ebenstein, K, Wu, T M, Tsai
Publikováno v: Molecular pharmacology. 47(5)
NAD(P):quinone acceptor oxidoreductase (quinone reductase) (DT-diaphorase, EC 1.6.99.2) is involved in the process of reductive activation of cytotoxic antitumor quinones and nitrobenzenes. In this study, we initially examined the relative abilities
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d96f2308a656f027baa32cc2d429b146
https://pubmed.ncbi.nlm.nih.gov/7746280
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5
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase
Autor: R J, Knox, F, Friedlos, R F, Sherwood, R G, Melton, G M, Anlezark
Publikováno v: Biochemical pharmacology. 44(12)
A nitroreductase enzyme that has been isolated from Escherichia coli B is capable of bioactivating CB1954 [5-(aziridin-1-yl)-2,4-dinitrobenzamide] to a cytotoxic agent, a property shared with the mammalian enzyme Walker DT diaphorase [NAD(P)H dehydro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7daa71e9a5673ece62562961bfa02bb4
https://pubmed.ncbi.nlm.nih.gov/1472095
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6
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT)
Autor: G M, Anlezark, R G, Melton, R F, Sherwood, B, Coles, F, Friedlos, R J, Knox
Publikováno v: Biochemical pharmacology. 44(12)
A nitroreductase enzyme has been isolated from Escherichia coli B. This enzyme is an FMN-containing flavoprotein with a molecular mass of 24 kDa and requires either NADH or NADPH as a cofactor. Partial protein sequence analysis showed extensive homol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df20235286d22e770c5f64f9fc00b77c
https://pubmed.ncbi.nlm.nih.gov/1472094
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7
Metabolism of NAD(P)H by blood components. Relevance to bioreductively activated prodrugs in a targeted enzyme therapy system
Autor: F, Friedlos, R J, Knox
Publikováno v: Biochemical pharmacology. 44(4)
NADH was metabolized both by serum components and at the cell surface. The metabolism by serum was either oxidation to NAD+, or hydrolysis of the pyrophosphate to yield nicotinamide mononucleotide (reduced) (NMNH) and AMP. NMNH was further hydrolysed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5842e6dfc4d832186ca9de1597a4c881
https://pubmed.ncbi.nlm.nih.gov/1387314
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8
The properties of total adducts and interstrand crosslinks in the DNA of cells treated with CB 1954. Exceptional frequency and stability of the crosslink
Autor: F, Friedlos, J, Quinn, R J, Knox, J J, Roberts
Publikováno v: Biochemical pharmacology. 43(6)
CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) becomes, upon bioactivation, a difunctional alkylating agent. It can be up to a 100,000-fold more cytotoxic in cells that are able to bioactivate it than in those that cannot. This increase in cytotoxi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae308984256f5b406bf23d72359b67f6
https://pubmed.ncbi.nlm.nih.gov/1562278
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10
Inhibition by caffeine of post-replication repair in Chinese hamster cells treated with 7-bromomethylbenz(a)anthracene: Enhancement of toxicity, chromosome damage and inhibition of ligation of newly-synthesized DNA
Autor: J.J. Roberts, D.J. Kirkland, H.W. Van Den Berg, F. Friedlos
Publikováno v: Chemico-Biological Interactions. 17:265-290
The lethal and chromosome damaging effects of 7-bromomethylbenz(a)anthracene (7-BMBA) on Chinese hamster cells in culture were enhanced by posttreatment incubation in non-toxic concentrations of caffeine. 7-BMBA produced a marked dose-dependent depre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1f64b9690df55eaf0f469f1f108430
https://doi.org/10.1016/0009-2797(77)90091-6
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