Zobrazeno 1 - 10
of 281
pro vyhledávání: '"F. Friedlos"'
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects; 1977, Vol. 46 Issue: 2 p151-151, 1p
Autor:
Khan M; Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University Chongqing, Chongqing, 400044, P. R. China., Dong Y; Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325016, P. R. China., Ullah R; Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Lab for Vascular Implants College of Bioengineering Chongqing University, Chongqing, 400030, P. R. China., Li M; School of Life Science, Chongqing University, Chongqing, 400044, P. R. China., Huang Q; Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University Chongqing, Chongqing, 400044, P. R. China., Hu Y; Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University Chongqing, Chongqing, 400044, P. R. China., Yang L; Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University Chongqing, Chongqing, 400044, P. R. China., Luo Z; School of Life Science, Chongqing University, Chongqing, 400044, P. R. China.
Publikováno v:
Advanced healthcare materials [Adv Healthc Mater] 2024 Nov; Vol. 13 (29), pp. e2401076. Date of Electronic Publication: 2024 Oct 07.
Publikováno v:
Gene Therapy. 5:105-112
Clones of human colon carcinoma (WiDr), ovarian carcinoma (SK-OV-3), and Chinese hamster V79 cells expressing the nitroreductase enzyme (NR) from E. coli B were 52-, 225- and 177-fold respectively more sensitive to a 24-h incubation with the prodrug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252dfc83ae51db6c5df25e0b0c23c74f
https://doi.org/10.1038/sj.gt.3300569
https://doi.org/10.1038/sj.gt.3300569
Publikováno v:
Anti-cancer drug design. 14(6)
Antibody- and gene-directed enzyme prodrug therapy are two-step targeting strategies designed to improve the selectivity of antitumour agents. The approaches are based on the activation of specially designed prodrugs by antibody-enzyme conjugates tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de2fd75ae312bda859b13b40f27443e9
https://pubmed.ncbi.nlm.nih.gov/10834273
https://pubmed.ncbi.nlm.nih.gov/10834273
Autor:
S. J. Weedon, David J. Kerr, Peter F. Searle, Caroline J. Springer, Lawrence S. Young, Iain A. McNeish, Moira G. Gilligan, F. Friedlos, M. J. Ford
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461374442
The enzyme nitroreductase from E. coli can reduce the relatively non-toxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) to the 2- or 4-hydroxylamino derivatives; the latter is a potent cytotoxic agent, which following further non-enzymatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::842bb9d2c2544519c87f9a4862471891
https://doi.org/10.1007/978-1-4615-5357-1_17
https://doi.org/10.1007/978-1-4615-5357-1_17
Autor:
S, Chen, R, Knox, A D, Lewis, F, Friedlos, P, Workman, P S, Deng, M, Fung, D, Ebenstein, K, Wu, T M, Tsai
Publikováno v:
Molecular pharmacology. 47(5)
NAD(P):quinone acceptor oxidoreductase (quinone reductase) (DT-diaphorase, EC 1.6.99.2) is involved in the process of reductive activation of cytotoxic antitumor quinones and nitrobenzenes. In this study, we initially examined the relative abilities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d96f2308a656f027baa32cc2d429b146
https://pubmed.ncbi.nlm.nih.gov/7746280
https://pubmed.ncbi.nlm.nih.gov/7746280
Publikováno v:
Biochemical pharmacology. 44(12)
A nitroreductase enzyme that has been isolated from Escherichia coli B is capable of bioactivating CB1954 [5-(aziridin-1-yl)-2,4-dinitrobenzamide] to a cytotoxic agent, a property shared with the mammalian enzyme Walker DT diaphorase [NAD(P)H dehydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7daa71e9a5673ece62562961bfa02bb4
https://pubmed.ncbi.nlm.nih.gov/1472095
https://pubmed.ncbi.nlm.nih.gov/1472095
Publikováno v:
Biochemical pharmacology. 44(12)
A nitroreductase enzyme has been isolated from Escherichia coli B. This enzyme is an FMN-containing flavoprotein with a molecular mass of 24 kDa and requires either NADH or NADPH as a cofactor. Partial protein sequence analysis showed extensive homol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df20235286d22e770c5f64f9fc00b77c
https://pubmed.ncbi.nlm.nih.gov/1472094
https://pubmed.ncbi.nlm.nih.gov/1472094
Autor:
F, Friedlos, R J, Knox
Publikováno v:
Biochemical pharmacology. 44(4)
NADH was metabolized both by serum components and at the cell surface. The metabolism by serum was either oxidation to NAD+, or hydrolysis of the pyrophosphate to yield nicotinamide mononucleotide (reduced) (NMNH) and AMP. NMNH was further hydrolysed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5842e6dfc4d832186ca9de1597a4c881
https://pubmed.ncbi.nlm.nih.gov/1387314
https://pubmed.ncbi.nlm.nih.gov/1387314
Publikováno v:
Biochemical pharmacology. 43(6)
CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) becomes, upon bioactivation, a difunctional alkylating agent. It can be up to a 100,000-fold more cytotoxic in cells that are able to bioactivate it than in those that cannot. This increase in cytotoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae308984256f5b406bf23d72359b67f6
https://pubmed.ncbi.nlm.nih.gov/1562278
https://pubmed.ncbi.nlm.nih.gov/1562278