Zobrazeno 1 - 10
of 152
pro vyhledávání: '"F. Eun-Hyung Lee"'
Autor:
Weirong Chen, So-Hee Hong, Scott A. Jenks, Fabliha A. Anam, Christopher M. Tipton, Matthew C. Woodruff, Jennifer R. Hom, Kevin S. Cashman, Caterina Elisa Faliti, Xiaoqian Wang, Shuya Kyu, Chungwen Wei, Christopher D. Scharer, Tian Mi, Sakeenah Hicks, Louise Hartson, Doan C. Nguyen, Arezou Khosroshahi, Saeyun Lee, Youliang Wang, Regina Bugrovsky, Yusho Ishii, F. Eun-Hyung Lee, Ignacio Sanz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced by long-lived plasma cells (LLPC). Active SLE generates increased circulating antibody-secreting cells (ASC)
Externí odkaz:
https://doaj.org/article/32d01e342442483b94987433b744c8c5
Autor:
Doan C. Nguyen, Celia Saney, Ian T. Hentenaar, Monica Cabrera-Mora, Violeta Capric, Matthew C. Woodruff, Joel Andrews, Sagar Lonial, Ignacio Sanz, F. Eun-Hyung Lee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Following infection or vaccination, early-minted antibody secreting cells (ASC) or plasmablasts appear in circulation transiently, and a small fraction migrates to the spleen or bone marrow (BM) to mature into long-lived plasma cells (LLPC).
Externí odkaz:
https://doaj.org/article/b7f801bdbca6431b98d45ea1a86c12fd
Autor:
Matthew C. Woodruff, Kevin S. Bonham, Fabliha A. Anam, Tiffany A. Walker, Caterina E. Faliti, Yusho Ishii, Candice Y. Kaminski, Martin C. Ruunstrom, Kelly Rose Cooper, Alexander D. Truong, Adviteeya N. Dixit, Jenny E. Han, Richard P. Ramonell, Natalie S. Haddad, Mark E. Rudolph, Srilakshmi Yalavarthi, Viktoria Betin, Ted Natoli, Sherwin Navaz, Scott A. Jenks, Yu Zuo, Jason S. Knight, Arezou Khosroshahi, F. Eun-Hyung Lee, Ignacio Sanz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract While immunologic correlates of COVID-19 have been widely reported, their associations with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of PASC presentations, understanding if specific disease features ass
Externí odkaz:
https://doaj.org/article/9d2aa0b3afa9462d9b276355450d5845
Autor:
Jeremy D. DeBarry, Mustafa V. Nural, Suman B. Pakala, Vishal Nayak, Susanne Warrenfeltz, Jay Humphrey, Stacey A. Lapp, Monica Cabrera-Mora, Cristiana F. A. Brito, Jianlin Jiang, Celia L. Saney, Allison Hankus, Hannah M. Stealey, Megan B. DeBarry, Nicolas Lackman, Noah Legall, Kevin Lee, Yan Tang, Anuj Gupta, Elizabeth D. Trippe, Robert R. Bridger, Daniel Brent Weatherly, Mariko S. Peterson, Xuntian Jiang, ViLinh Tran, Karan Uppal, Luis L. Fonseca, Chester J. Joyner, Ebru Karpuzoglu, Regina J. Cordy, Esmeralda V. S. Meyer, Lance L. Wells, Daniel S. Ory, F. Eun-Hyung Lee, Rabindra Tirouvanziam, Juan B. Gutiérrez, Chris Ibegbu, Tracey J. Lamb, Jan Pohl, Sarah T. Pruett, Dean P. Jones, Mark P. Styczynski, Eberhard O. Voit, Alberto Moreno, Mary R. Galinski, Jessica C. Kissinger
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-43 (2022)
Measurement(s) parasitemia • blood Chemistry • reticulocyte count • platelet activation status • neutrophil and monocyte activation after stimulation • T-cell phenotyping • B-cell phenotyping • monocyte phenotyping • dendritic cell ph
Externí odkaz:
https://doaj.org/article/8706a9e9716845819613fdcc3852e381
Autor:
Meixue Duan, Doan C. Nguyen, Chester J. Joyner, Celia L. Saney, Christopher M. Tipton, Joel Andrews, Sagar Lonial, Caroline Kim, Ian Hentenaar, Astrid Kosters, Eliver Ghosn, Annette Jackson, Stuart Knechtle, Stalinraja Maruthamuthu, Sindhu Chandran, Tom Martin, Raja Rajalingam, Flavio Vincenti, Cynthia Breeden, Ignacio Sanz, Greg Gibson, F. Eun-Hyung Lee
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112682- (2023)
Summary: Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived antibody-secreting cells (ASCs) to long-lived plasma cells (LLPCs). We provide single-cell transcriptional resolution of 17,347 BM ASCs from five healthy adult
Externí odkaz:
https://doaj.org/article/e2cfa9f8c92144a5ae6fadda3ba129f7
Autor:
Amy B. Karger, James D. Brien, Jayne M. Christen, Santosh Dhakal, Troy J. Kemp, Sabra L. Klein, Ligia A. Pinto, Lakshmanane Premkumar, John D. Roback, Raquel A. Binder, Karl W. Boehme, Suresh Boppana, Carlos Cordon-Cardo, James M. Crawford, John L. Daiss, Alan P. Dupuis, Ana M. Espino, Adolfo Firpo-Betancourt, Catherine Forconi, J. Craig Forrest, Roxie C. Girardin, Douglas A. Granger, Steve W. Granger, Natalie S. Haddad, Christopher D. Heaney, Danielle T. Hunt, Joshua L. Kennedy, Christopher L. King, Florian Krammer, Kate Kruczynski, Joshua LaBaer, F. Eun-Hyung Lee, William T. Lee, Shan-Lu Liu, Gerard Lozanski, Todd Lucas, Damodara Rao Mendu, Ann M. Moormann, Vel Murugan, Nkemakonam C. Okoye, Petraleigh Pantoja, Anne F. Payne, Jin Park, Swetha Pinninti, Amelia K. Pinto, Nora Pisanic, Ji Qiu, Carlos A. Sariol, Viviana Simon, Lusheng Song, Tara L. Steffen, E. Taylor Stone, Linda M. Styer, Mehul S. Suthar, Stefani N. Thomas, Bharat Thyagarajan, Ania Wajnberg, Jennifer L. Yates, Kimia Sobhani
Publikováno v:
mSphere, Vol 7, Iss 4 (2022)
ABSTRACT In October 2020, the National Cancer Institute (NCI) Serological Sciences Network (SeroNet) was established to study the immune response to COVID-19, and “to develop, validate, improve, and implement serological testing and associated tech
Externí odkaz:
https://doaj.org/article/15b0a867b0c944c198dfb5ce4d592d6a
Autor:
William T. Hu, J. Christina Howell, Tugba Ozturk, Karima Benameur, Leda C. Bassit, Richard Ramonell, Kevin S. Cashman, Shama Pirmohammed, John D. Roback, Vincent C. Marconi, Irene Yang, Valerie V. Mac, Daniel Smith, Ignacio Sanz, Whitney Wharton, F. Eun-Hyung Lee, Raymond F. Schinazi
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 12, Pp 2974-2978 (2020)
Among patients with coronavirus disease (COVID-19), IgM levels increased early after symptom onset for those with mild and severe disease, but IgG levels increased early only in those with severe disease. A similar pattern was observed in a separate
Externí odkaz:
https://doaj.org/article/e763d22d1815415ea1ca5c5f3ff79d91
Autor:
Xingyu Yang, Christopher M. Tipton, Matthew C. Woodruff, Enlu Zhou, F. Eun-Hyung Lee, Inãki Sanz, Peng Qiu
Publikováno v:
BMC Genomics, Vol 21, Iss S9, Pp 1-11 (2020)
Abstract Background B cell affinity maturation enables B cells to generate high-affinity antibodies. This process involves somatic hypermutation of B cell immunoglobulin receptor (BCR) genes and selection by their ability to bind antigens. Lineage tr
Externí odkaz:
https://doaj.org/article/b30f5e079be94fa7b7b9721dd8712f49
Autor:
Doan C. Nguyen, Swetha Garimalla, Haopeng Xiao, Shuya Kyu, Igor Albizua, Jacques Galipeau, Kuang-Yueh Chiang, Edmund K. Waller, Ronghu Wu, Greg Gibson, James Roberson, Frances E. Lund, Troy D. Randall, Iñaki Sanz, F. Eun-Hyung Lee
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Antibody-secreting cells (ASC) such as plasma cells must migrate to the bone marrow to survive, but microniche elements that promote survival are unknown. Here the authors define specific factors from the microniche that can maintain ASC in vitro for
Externí odkaz:
https://doaj.org/article/8d6c5b762cbe4e5192797c6d2043c3fe
Autor:
Shuya Kyu, Richard P. Ramonell, Merin Kuruvilla, Colleen S. Kraft, Yun F. Wang, Ann R. Falsey, Edward E. Walsh, John L. Daiss, Simon Paulos, Gowrisankar Rajam, Hao Wu, Srinivasan Velusamy, F. Eun-Hyung Lee
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Background Streptococcus pneumoniae infections cause morbidity and mortality worldwide. A rapid, simple diagnostic method could reduce the time needed to introduce definitive therapy potentially improving patient outcomes. Methods We introduce two ne
Externí odkaz:
https://doaj.org/article/15e224246af34ae5945e28ffa76e7365